Butyrate Increases Heparin Synthesis and Storage in Human Mast Cells
Syed Benazir Alam,
Zhimin Yan,
Nishita Hiresha Verma
et al.
Abstract:Sulphated glycosaminoglycans (GAGs) such as heparin are a major component of mast cell granules and form the matrix within which biogenic mediators are stored. Since GAGs released from mast cells also play an important role in helminth expulsion, understanding GAG storage can offer new insights into mast cell function. Sodium butyrate (NaBu), a short-chain fatty acid, causes ultrastructural changes within the granules of human mast cells (HMC-1) and increases their histamine content. Therefore, we hypothesized… Show more
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