Butyltin residues in livers of humans and wild terrestrial mammals and in plastic products

Takahashi, Shin; Mukai, Hiroto; Tanabe, Shinsuke; Sakayama, Kenshi; Miyazaki, Taeko; Masuno, Hiroshi

doi:10.1016/s0269-7491(99)00068-8

Cited by 178 publications

(96 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…After 1994, reports from several authors on the presence of TBT in higher organisms including cetaceans (Iwata et al, 1994;Kannan & Falandysz, 1997;, marine birds (Guruge et al, 1997a(Guruge et al, , 1997b and humans (Kannan & Falandysz, 1997;Takahashi et al, 1999) demonstrated that organotin compounds are likely to be transferred among different trophic levels.…”

Section: Introductionmentioning

confidence: 99%

Occurrence of imposex in Thais haemastoma: possible evidence of environmental contamination derived from organotin compounds in Rio de Janeiro and Fortaleza, Brazil

et al. 2002

View full text Add to dashboard Cite

There are indications that the widespread use of organotin compounds (TBT and TPT) as antifoulings, as stabilizers in plastic and as pesticides, has severely affected several species of marine organisms. The most striking effect of TBT and TPT as hormonal disruptors is the development of male organs in females of gastropods, currently denominated imposex. This syndrome can lead to the sterilization and death of affected organisms. The present work gives an overview of the present state of knowledge on imposex occurrence and reports results of a survey conducted in Guanabara Bay, Rio de Janeiro and in several sites along the coast of Fortaleza, Ceará State. Different stages of imposex development were verified in this survey, however, the most prominent levels appeared associated to known spot sources of TBT and TPT.

show abstract

Section: Introductionmentioning

confidence: 99%

Occurrence of imposex in Thais haemastoma: possible evidence of environmental contamination derived from organotin compounds in Rio de Janeiro and Fortaleza, Brazil

et al. 2002

View full text Add to dashboard Cite

show abstract

“…High levels of butyltins were detected in human liver tissue and blood samples. For example, total butyltin concentrations in human livers collected from Poland are in the range 2.4-11 ng/g wet weight [5], and butyltin concentrations in the livers of Japanese are in the range 59-96 ng/g wet weight [6]. Kannan et al [7] reported that TBT levels in human blood collected from the United States were up to 8.18 ng/mL.…”

Section: Reverse-transcriptional Real-time Pcr (Rt-pcr)mentioning

confidence: 99%

Wpływ tributylocyny na przyjmowanie pokarmu i ekspresję neuropeptydów w mózgu szczurów

Zhang

Chen

2015

Endokrynologia Polska

View full text Add to dashboard Cite

Introduction: Tributyltin (TBT) is a largely diffused environmental pollutant. Several studies have demonstrated that TBT is involved in the development of obesity. However, few studies addressing the effects of TBT on the brain neuropeptides involved in appetite and body weight homeostasis have been published. Material and methods: Experiments were carried out on female and male Sprague-Dawley rats. Animals were exposed to TBT (0.5 μg/kg body weight) for 54 days. The hepatic triglyceride and total cholesterol were determined using commercial enzyme kits. The NPY, AgRP, POMC and CART mRNA expression in brains were quantified by real-time PCR. Results: TBT exposure resulted in significant increases in the hepatic total cholesterol and triglyceride concentration of both male and female rats. Interestingly, increases in body weight and fat mass were only found in the TBT-treated male rats. TBT exposure also led to a significant increase in food intake by the female rats, while no change was observed in the male rats. Moreover, the neuropeptides expression was different between males and females after TBT exposure. TBT induced brain NPY expression in the female rats, and depressed brain POMC, AgRP and CART expression in the males. Conclusions: TBT can increase food intake in female rats, which is associated with the disturbance of NPY in brains. TBT had sex-different effects on brain NPY, AgRP, POMC and CART mRNA expression, which indicates a complex neuroendocrine mechanism of TBT.

show abstract

“…In Finland, TPT were detected as the predominant comseafoods (Rantakokko et al, 2006). In addition, a variety -taminating trialkyl species, are also prevalently used as bringing them into closer contact with drinking water and food supplies (Takahashi et al, 1999).…”

Section: Possible Human Exposure To Organotin Compoundsmentioning

confidence: 99%

Endocrine disruption induced by organotin compounds; organotins function as a powerful agonist for nuclear receptors rather than an aromatase inhibitor

Nakanishi

2008

J. Toxicol. Sci.

140

View full text Add to dashboard Cite

ABSTRACTing nets, agricultural fungicides and rodent repellents. These widespread uses have resulted in the release of increasing amounts of organotins into the environment. In aquatic invertebrates, particularly marine gastropods, organotin compounds, such as tributyltin (TBT) and triphenyltin (TPT), induce irreversible sexual abnormality in females which is termed "imposex" at very low concentrations. Although it has been theorized that these compounds act as potential competitive inhibitors of aromatase, which converts androgen to estrogen, and then increase levels of unconverted androgens in gastropods, their effective concentrations for aromatase inhibition are high. In addition to wildlife, organotins may have various undesirable effects on human health. Contrary to the theory of organotin-induced aromatase inhibition in gastropods, in human choriocarcinoma cells, these compounds markedly enhance estradiol biosynthe-HSD I) activity, which converts low-activity estrogen estrone to the biologically more active form estradiol, at the same low concentrations. Although there are many reports describing the potential toxicity of organotins in human and mammals, the critical target molecules for the toxicity of organotin compounds are members of the nuclear receptor superfamily. Here, we review the potential genetics action and subsequent toxicity induced by organotins via these nuclear receptors.

show abstract

Butyltin residues in livers of humans and wild terrestrial mammals and in plastic products

Cited by 178 publications

References 33 publications

Occurrence of imposex in Thais haemastoma: possible evidence of environmental contamination derived from organotin compounds in Rio de Janeiro and Fortaleza, Brazil

Occurrence of imposex in Thais haemastoma: possible evidence of environmental contamination derived from organotin compounds in Rio de Janeiro and Fortaleza, Brazil

Wpływ tributylocyny na przyjmowanie pokarmu i ekspresję neuropeptydów w mózgu szczurów

Endocrine disruption induced by organotin compounds; organotins function as a powerful agonist for nuclear receptors rather than an aromatase inhibitor

Contact Info

Product

Resources

About