Butyltin compounds alter secretion of interleukin 6 from human immune cells

Brown, Shyretha; Wilburn, Wendy; Martin, Tyesha; Whalen, Margaret M.

doi:10.1002/jat.3514

Cited by 15 publications

(10 citation statements)

References 73 publications

(145 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Thus, TBT is an inducer of oxidative stress and plays an important role in the positive modulation of pro-inflammatory cytokines ( 45 ). This is consistent with data showing a decreased activity of SOD, CAT, and GPX in other species ( 46 , 47 ), a higher expression of HSP70 in common carp ( 48 ), an increased IL-1β secretion by human immune cells ( 49 ), an increased IL-6 production in human peripheral blood mononuclear cells ( 50 ), and higher TNF-α levels in mouse serum ( 51 ).…”

Section: Introductionsupporting

confidence: 91%

Tributyltin and Zebrafish: Swimming in Dangerous Water

et al. 2018

View full text Add to dashboard Cite

Zebrafish has been established as a reliable biological model with important insertion in academy (morphologic, biochemical, and pathophysiological studies) and pharmaceutical industry (toxicology and drug development) due to its molecular complexity and similar systems biology that recapitulate those from other organisms. Considering the toxicological aspects, many efforts using zebrafish models are being done in order to elucidate the effects of endocrine disruptors, and some of them are focused on tributyltin (TBT) and its mechanism of action. TBT is an antifouling agent applied in ship’s hull that is constantly released into the water and absorbed by marine organisms, leading to bioaccumulation and biomagnification effects. Thus, several findings of malformations and changes in the normal biochemical and physiologic aspects of these marine animals have been related to TBT contamination. In the present review, we have compiled the most significant studies related to TBT effects in zebrafish, also taking into consideration the effects found in other study models.

show abstract

Section: Introductionsupporting

confidence: 91%

Tributyltin and Zebrafish: Swimming in Dangerous Water

et al. 2018

View full text Add to dashboard Cite

show abstract

“…These include interferon gamma (IFNγ), tumor necrosis factor alpha (TNFα), IL-1β, and IL-6 (Hurt et al . 2013; Lawrence et al, 2015; Brown and Whalen, 2015; Brown et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

“…TBT has been shown to alter the secretion of both IL-1β and IL-6 from human lymphocytes (Brown and Whalen, 2015; Brown et al, 2018). The current study examines whether these alterations in secretion are due to changes in the lymphocytes’ synthesis of these cytokines or if it is simply due to changes in the secretion of pre-existing cytokine.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of interleukin 1 beta and interleukin 6 in human lymphocytes is stimulated by tributyltin

et al. 2018

Self Cite

View full text Add to dashboard Cite

Tributyltin (TBT) is a widespread environmental contaminant that is present in human blood and other tissues. It has been shown to disrupt the immune function of human natural killer (NK) cells and to alter the secretion of a number of pro-inflammatory cytokines from immune cells. Secretion of both interleukin 1β (IL-1β) and interleukin 6 (IL-6) from human lymphocytes can be increased dependent upon the level of TBT exposure. This study shows that the TBT-induced increases in secretion of both cytokines are due to TBT-induced increases in the synthesis of these proteins and not simply because of the release of pre-existing cytokine. Furthermore, the data indicate that these TBT-induced increases in IL-1β and IL-6 synthesis require MAP kinase signaling pathways. Additionally, elevated synthesis of IL-1β and IL-6 seen at the highest exposures to TBT (200, 200, 50 nM) were accompanied by increases in the mRNA for these cytokines. TBT-induced increases in IL-1β and IL-6 mRNAs were also shown to be dependent on MAP kinase signaling. The study suggests that TBT has the capacity to increase immune cell production of these 2 important pro-inflammatory cytokines and that this increase is in part explained by increased mRNA for the cytokines.

show abstract

“…This OTs’ presence in human blood was able to compromise the natural killer (NK) cells activity in vitro ( 9 ). Also, Brown and colleague, in 2017 ( 10 ), reported that OTs alters the interleukin 6 (IL-6) secretion from human immune cells and consequently, affect the immune competence ( 10 ). In 2014, Valenzuela and colleagues ( 11 ) developed an efficient methodology capable to identify 11 OT compounds in urine from harbor workers exposed to antifouling paints.…”

Section: Introductionmentioning

confidence: 99%

The Pollutant Organotins Leads to Respiratory Disease by Inflammation: A Mini-Review

et al. 2018

View full text Add to dashboard Cite

Organotins (OTs) are organometallic pollutants. The OTs are organometallic pollutants that are used in many industrial, agricultural, and domestic products, and it works as powerful biocidal compound against large types of microorganisms such as fungi and bacteria. In addition, OTs are well known to be endocrine-disrupting chemicals, leading abnormalities an “imposex” phenomenon in the female mollusks. There are some studies showing that OTs’ exposure is responsible for neural, endocrine, and reproductive dysfunctions in vitro and in vivo models. However, OTs’ effects over the mammalian immune system are poorly understood, particularly in respiratory diseases. The immune system, as well as their cellular components, performs a pivotal role in the control of the several physiologic functions, and in the maintenance and recovery of homeostasis. Thus, it is becoming important to better understand the association between environmental contaminants, as OTs, and the physiological function of immune system. There are no many scientific works studying the relationship between OTs and respiratory disease, especially about immune system activation. Herein, we reported studies in animal, humans, and in vitro models. We searched studies in PUBMED, LILACS, and Scielo platforms. Studies have reported that OTs exposure was able to suppress T helper 1 (Th1) and exacerbate T helper 2 (Th2) response in the immune system. In addition, OTs’ contact could elevate in the airway inflammatory response, throughout a mechanism associated with the apoptosis of T-regulatory cells and increased oxidative stress response. In addition, OTs induce macrophage recruitment to the tissue, leading to the increased necrosis, which stimulates an inflammatory cytokines secretion exacerbating the local inflammation and tissue function loss. Thus, the main intention of this mini-review is to up to date the main findings involving the inflammatory profile (especially Th1 and Th2 response) in the respiratory tract as a result of OTs’ exposure.

show abstract

Butyltin compounds alter secretion of interleukin 6 from human immune cells

Cited by 15 publications

References 73 publications

Tributyltin and Zebrafish: Swimming in Dangerous Water

Tributyltin and Zebrafish: Swimming in Dangerous Water

Synthesis of interleukin 1 beta and interleukin 6 in human lymphocytes is stimulated by tributyltin

The Pollutant Organotins Leads to Respiratory Disease by Inflammation: A Mini-Review

Contact Info

Product

Resources

About