2012
DOI: 10.3390/molecules17077645
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Butylated Hydroxytoluene Analogs: Synthesis and Evaluation of Their Multipotent Antioxidant Activities

Abstract: A computer-aided predictions of antioxidant activities were performed with the Prediction Activity Spectra of Substances (PASS) program. Antioxidant activity of compounds 1, 3, 4 and 5 were studied using 1,1-diphenyl-2-picrylhydrazyl (DPPH) and lipid peroxidation assays to verify the predictions obtained by the PASS program. Compounds 3 and 5 showed more inhibition of DPPH stable free radical at 10−4 M than the well-known standard antioxidant, butylated hydroxytoluene (BHT). Compound 5 exhibited promising in v… Show more

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Cited by 51 publications
(47 citation statements)
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“…15 No C-S bond cleavage was observed in that reaction. 15 However hydrazination of ester 4 does not proceed as expected, instead compounds 5a and 5b were isolated.…”
Section: Mechanistic Discussionmentioning
confidence: 83%
See 3 more Smart Citations
“…15 No C-S bond cleavage was observed in that reaction. 15 However hydrazination of ester 4 does not proceed as expected, instead compounds 5a and 5b were isolated.…”
Section: Mechanistic Discussionmentioning
confidence: 83%
“…15 No C-S bond cleavage was observed in that reaction. 15 However hydrazination of ester 4 does not proceed as expected, instead compounds 5a and 5b were isolated. The observed products, 5a and 5b in Scheme 2 could be attributed to the stability of the resulting intermediate, quinone methide.…”
Section: Mechanistic Discussionmentioning
confidence: 83%
See 2 more Smart Citations
“…The incessant stage of mycobacterial infection stands as one of the biggest challenge in management of tuberculosis treatment; this is the phase in bacterial lifecycle when it is considered to be in a slowgrowing or non-growing state 6 . Hydrazinecarbothioamides or thiosemicarbazones consist of an imperative class of nitrogen and sulfur containing compounds, and have acknowledged huge attention owing to their notable biological and pharmacological properties, such as antimycobacterial 9 , antioxidant 10,11 , antibacterial 12 , antiviral, antiamoebic, and antitumor 13 , analgesic, anti-inflammatory 14 and antifungal 15 . Considering this fact, multidrug therapies of longer durations are prescribed in tuberculosis medication.…”
Section: Introductionmentioning
confidence: 99%