Butein ameliorates chronic stress induced atherosclerosis via targeting anti-inflammatory, anti-fibrotic and BDNF pathways

Rehman, Mujeeba; Chaudhary, Rishabh; Rajput, Sonu; Agarwal, Vipul; Kaushik, Arjun Singh; Srivastava, Siddhi; Srivastava, Sukriti; Singh, Rohit; Aziz, Irfan; Singh, Sanjay; Mishra, Vikas

doi:10.1016/j.physbeh.2023.114207

Cited by 3 publications

(1 citation statement)

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“…In the inflammatory response, macrophages secrete large amounts of tumor necrosis factor (TNF-α), interleukin-6 (IL-6), and other pro-inflammatory factors that participate in the body's immune response. In a mouse model of atherosclerosis, butein reduced the release of pro-inflammatory factors interleukin-1β (IL-1β), IL-6, and TNF-α, thus demonstrating its anti-inflammatory properties [3]. Inflammation is the body's defensive immune response triggered by bacterial or viral infection, cellular damage, and so on.…”

Section: Introductionmentioning

confidence: 99%

Testing of Anti-EMT, Anti-Inflammatory and Antibacterial Activities of 2′,4′-Dimethoxychalcone

Zhao,

Xu,

Gong

et al. 2024

Pharmaceuticals

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Chalcone (1,3-diaryl-2-propen-1-one) is an α, β-unsaturated ketone that serves as an active constituent or precursor of numerous natural substances, exhibiting a broad spectrum of pharmacological effects. In this study, the classical Claisen–Schmidt condensation method was used to synthesize the chalcone derivative 2′,4′-dimethoxychalcone (DTC) and evaluate its pharmacological activity. By upregulating the expression of the epithelial cell marker E-cadherin and downregulating the expression of the mesenchymal cell marker vimentin, DTC was found to inhibit transforming growth factor-β1 (TGF-β1)-induced epithelial–mesenchymal transition (EMT) process in A549 cells, maintaining the cells’ epithelial-like morphology and reducing the ability of the cells to migrate. Additionally, DTC demonstrated the ability to decrease the expression levels of nitric oxide (NO), tumor necrosis factor (TNF-α), interleukin-6 (IL-6), and interleukin-1β (IL-1β) in RAW264.7 cells, suggesting a possible anti-inflammatory effect. Furthermore, DTC was found to exhibit bacteriostatic activity against Staphylococcus aureus (S. aureus), Proteus vulgaris (P. vulgaris), methicillin-resistant Staphylococcus aureus (MRSA), and Candida albicans (C. albicans), indicating that this chemical may possess broad-spectrum antibacterial activity.

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Section: Introductionmentioning

confidence: 99%