Butea monosperma and chemomodulation: Protective role against thioacetamide-mediated hepatic alterations in Wistar rats

Sehrawat, Anuradha; Khan, Tajdar Husain; Prasad, Lakshmi; Sultana, Sarwat

doi:10.1016/j.phymed.2004.11.007

Cited by 38 publications

(22 citation statements)

References 18 publications

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“…Oxidative stress may play an important role in TAA-induced liver injury [20,21]. In the current study, hepatocyte necrosis and inflammation induced by TAA resulted in a significant increase in ALT and GGT levels (which are commonly used as biochemical markers of liver injury), as compared to the control group [22,23].…”

Section: Discussionmentioning

confidence: 58%

Effect of histidine on autotaxin activity in experimentally induced liver fibrosis

El-Batch

Ibrahim

Said

2010

J Biochem & Molecular Tox

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The aim of this study was to explain whether serum autotaxin (ATX) activity might be a target for regulation of liver fibrosis and to evaluate the hepatoprotective and antifibrotic effects of histidine in thioacetamide (TAA)-induced liver fibrosis in rats. This study was carried out on 100 Wistar Albino rats, classified into five groups, each containing 20 rats: Group I (control group), Group II: rats were given histidine intraperitoneally, Group III: rats were injected intraperitoneally with TAA, Group IV: rats were injected with L-histidine together with TAA, and Group V: rats were injected with TAA for 1 month then treated with intraperitoneal injection of L-histidine for another month. At the end of experiment, blood and liver were collected for determination of some liver enzymes, plasma total antioxidant capacity (TAC), serum ATX activity, and liver tissue hydroxyproline. Thioacetamide treatment caused significant increases in liver enzymes, ATX activities, and liver hydroxyproline, but a significant decrease in plasma's TAC. Upon treatment with histidine, a significant decrease in liver enzymes, ATX activities, and liver hydroxyproline was observed with a significant increase in plasma TAC in Group IV and a significant decrease in Group V. Histidine as an antioxidant has a protective effect on TAA-induced liver fibrosis; it is beneficial in rats not only by inhibition of collagen synthesis and increasing TAC but also by inhibition of ATX activities thus reducing its capacity to produce lysophosphatidic acid, which has a role in liver fibrosis. C 2010 Wiley Periodicals, Inc. J Biochem Mol Toxicol 25:143-150, 2011; View this article online at wileyonlinelibrary.com.

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Section: Discussionmentioning

confidence: 58%

Effect of histidine on autotaxin activity in experimentally induced liver fibrosis

El-Batch

Ibrahim

Said

2010

J Biochem & Molecular Tox

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“…They have been recognized as functionally active molecules, possessing antioxidant, anticancer, antimutagenic properties, as well as exerting protective effects against several other diseases (Ferguson, 2001;Nakamura et al, 2001). Reports from our laboratory have also confirmed antioxidative, antigenotoxic and anti-tumor promotion role of tannic acid (Sehrawat et al, 2006;Ahmad and Sultana, 2012).…”

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confidence: 55%

“…All the rats were anaesthetized with mild anaesthesia and sacrificed by cervical dislocation after 24 hr of the DMH injection. The doses of tannic acid were selected on the basis preliminary studies performed in our laboratory and also on the basis of available literature (Sehrawat et al, 2006;Ahmad and Sultana, 2012). Our study was approved by the Institutional Animal Ethics Committee (IAEC) of the university with registration no 599.…”

Section: Animals and Treatment Schedulementioning

confidence: 99%

Amelioration of 1,2 Dimethylhydrazine (DMH) Induced Colon Oxidative Stress, Inflammation and Tumor Promotion Response by Tannic Acid in Wistar Rats

Hamiza¹,

Rehman²,

Tahir³

et al. 2012

Asian Pacific Journal of Cancer Prevention

100

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Colon cancer is the third most common malignant neoplasm in the world and it remains an important cause of death, especially in western countries. The toxic environmental pollutant, 1, 2-dimethylhydrazine (DMH), is also a colon-specific carcinogen. Tannic acid (TA) is reported to be effective against various types of chemically induced toxicity and also carcinogenesis. In the present study, we evaluated the chemopreventive efficacy of TA against DMH induced colon toxicity in a rat model. Efficacy of TA against the colon toxicity was evaluated in terms of biochemical estimation of antioxidant enzyme activities, lipid peroxidation, histopathological changes and expression of early molecular markers of inflammation and tumor promotion. DMH treatment induced oxidative stress enzymes (p<0.001) and an early inflammatory and tumor promotion response in the colons of Wistar rats. TA treatment prevented deteriorative effects induced by DMH through a protective mechanism that involved reduction of oxidative stress as well as COX-2, i-NOS, PCNA protein expression levels and TNF-α (p<0.001) release. It could be concluded from our results that TA markedly protects against chemically induced colon toxicity and acts plausibly by virtue of its antioxidant, anti-inflammatory and antiproliferative activities.

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“…12) From the flowers of this plant species the flavonoids butin (1), butein (2), butrin (3), isobutrin, palasitrin, coreopsin, isocoreopsin, sulphuresin, monospermoside (4), isomonospermoside (5) and 7,3Ј,4Ј-trihydroxyflavone (6) have been isolated. [13][14][15] Antihepatotoxic activity of the flower extract 16) and of compound 3 and isobutrin 17) has been observed. Compound 1 which was isolated from the seeds of this plant species showed estrogenic and postcoital anti-conceptive activity in rats.…”

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confidence: 91%

Bioactive Flavonoids of the Flowers of Butea monosperma

et al. 2009

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Butea monosperma (LAM.) TAUB. (Fabaceae), known in Thai as Tong-kwoaw, is a medium sized deciduous tree of up to 50 feet high with stunning flower clusters, very conspicuous when in flower, and the trunk is usually crooked and twisted with irregular branches and rough, grey bark. The flowers are bright orange red, large and in rigid racemes. 1)This plant species has been found to display a wide variety of biological activities. The stem bark is used in indigenous medicine for the treatment of dyspepsia, diarrhea, dysentery, diabetes, ulcers, sore throat and snake bites.2) The flower extract showed antidiabetic effect in rats.3) The plant leaves exhibited antiinflammatory effect 4) and exerted effect on stress, anxiety and cognition in rats.5) Anti-diarrhoeal activity of the ethanolic extract of the stem bark 6) and anticonvulsive activity of the petroleum ether extract of the flowers 7) of this plant species in experimental animals have been reported. The plant extracts exhibited other biological activities including aphrodisiac activity in male rats, 8) anthelmintic activity, 9,10) and dermal wound healing in rats. 11) Isolation of (Ϫ)-medicarpin with antifungal activity from this part of the plant has also been reported. 12) From the flowers of this plant species the flavonoids butin (1), butein (2), butrin (3), isobutrin, palasitrin, coreopsin, isocoreopsin, sulphuresin, monospermoside (4), isomonospermoside (5) and 7,3Ј,4Ј-trihydroxyflavone (6) have been isolated. [13][14][15] Antihepatotoxic activity of the flower extract 16) and of compound 3 and isobutrin 17) has been observed. Compound 1 which was isolated from the seeds of this plant species showed estrogenic and postcoital anti-conceptive activity in rats.18) A lectin was also isolated from the seeds and was found to agglutinate human erythrocytes. The activity was inhibited by N-acetyl galactosamine and did not require a divalent ion.19) The euphane triterpenoid 3a-hydroxyeuph-25-ene and the alcohol 2,14-dihydroxy-11,12-dimethyl-8-oxo-octadec-11-enylcyclohexane have been isolated from the stem.20) The imide palasimide has been isolated from the pods of this plant species.21) Stigmasterol, stigmasterol-3-O-b-D-glucopyranoside and nonacosanoic acid were also among those isolated compounds. 15,20) As part of an ongoing project on bioactive compounds from Thai medicinal plants for the treatments of tropical diseases, the plant species was investigated and it was found that the EtOAc and MeOH extracts exhibited antimycobacterial activity. The present report deals with the One new dihydrochalcone, dihydromonospermoside (7), was isolated from the flowers of Butea monosperma together with three known chalcones, butein (2), monospermoside (4) and isoliquiritigenin (8), one flavone, 7,3 ,4 -trihydroxyflavone (6), four flavanones, (؊)-butin (1a), (؊)-butrin (3a), (؉)-isomonospermoside (5b) and (؊)-liquiritigenin (9a), and three isoflavones, formononetin (10), afrormosin (11) and formononetin-7-O-b b-D-glucopyranoside (12). The structure of the new compound was e...

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Butea monosperma and chemomodulation: Protective role against thioacetamide-mediated hepatic alterations in Wistar rats

Cited by 38 publications

References 18 publications

Effect of histidine on autotaxin activity in experimentally induced liver fibrosis

Effect of histidine on autotaxin activity in experimentally induced liver fibrosis

Amelioration of 1,2 Dimethylhydrazine (DMH) Induced Colon Oxidative Stress, Inflammation and Tumor Promotion Response by Tannic Acid in Wistar Rats

Bioactive Flavonoids of the Flowers of Butea monosperma

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