Butazolidin Plasma Concentration and Urinary Excretion in Normal Individuals and in Patients with Rheumatoid Spondylitis.

The Estimation of Butazolidin in Blood

“…Stanfield et al (1953) and others have described the finding of such tablets intact in the stools. In addition to the possibility of incomplete absorption, the rate of metabolism of " butazolidin " varies greatly from patient to patient, and the serum level is not generally predictable from a consideration of the dosage schedule.…”

“…Brodie and Burns (1952) extracted acidified plasma with heptane, and, after returning the butazolidin to aqueous alkali, determined the optical density at 265 myA with an ultra-violet spectrophotometer. The method was modified by Stanfield, Brodie, and Yeoman (1953), and it is simple and accurate. It requires, however, the use of an expensive instrument which is not generally available.…”

One‐pot PTC synthesis of polyfused pyrazoles

“…Also, fused pyrazoles have fungicidal [2,3], herbicidal [4,5], virucidal [6], insecticidal [7,8] activity and used for the treatment of rheumatoid arthritis [9][10][11]. The chemistry of pyrazoles has received much attention and many methods for their synthesis have been developed [12].…”