Butanol Fraction of Kelussia odoratissima Mozaff Inhibits the Growth of Leishmania major Promastigote and Amastigote

Mirzaei, Farzaneh; Norouzi, Roghayeh; Siyadatpanah, Abolghasem; Mitsuwan, Watcharapong; Nilforoushzadeh, Mohammadali; Maleksabet, Amir; Hosseini, Mirza Hassan; Pereira, Maria de Lourdes; Nissapatorn, Veeranoot; Hejazi‬, ‪Seyed Hossein

doi:10.36380/scil.2020.wvj33

Cited by 5 publications

(3 citation statements)

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“…Moreover, 1,8-cineole, α-pinene, and p-cymene active constituents of Protium altsonii and P. hebetatum (Burseraceae) exhibited dose-dependent amastigote inhibition with IC 50 of 48.4, 37, and 46 μg/ml, respectively (Santana et al, 2020). Butanol fraction of K. odoratissima with 154.1 μg/ml IC 50 value showed antileishmanial properties against L. major promastigote and amastigote (Mirzaei et al, 2020).…”

Section: Involvement Of Plant Extracts and Plant-derived Secondary Metabolitesmentioning

confidence: 98%

Green Approach: ‘‘A Forwarding Step for Curing Leishmaniasis—A Neglected Tropical Disease’’

Sharma

Dhiman

Singh

et al. 2021

Front. Mol. Biosci.

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The present review focuses on a dreaded vector-mediated leishmaniasis, with the existing therapeutic approaches including a variety of drugs along with their limitations, the treatment with natural compounds, and different types of metal/metal oxide nanoparticles (NPs). As evidenced, various metallic NPs, comprising silver, silver oxide, gold, zinc oxide, titanium, lead oxide, etc., played a curative role to treat leishmaniasis, are also presented. Keeping in view the advance success of vaccines against the prevalent dreaded diseases in the past and the present scenario, efforts are also being made to develop vaccines based on these NP formulations.

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Section: Involvement Of Plant Extracts and Plant-derived Secondary Metabolitesmentioning

confidence: 98%

Green Approach: ‘‘A Forwarding Step for Curing Leishmaniasis—A Neglected Tropical Disease’’

Sharma

Dhiman

Singh

et al. 2021

Front. Mol. Biosci.

View full text Add to dashboard Cite

show abstract

“…Furthermore, the active components 1,8-cineole, -pinene, and p-cymene from Protium altsonii and P. hebetatum (Burseraceae) showed dose-dependent amastigote inhibition, with IC50 values of 48.4, 37, and 46 g/ml, respectively (Moreira et al 2019). The butanol fraction of K. odoratissima displayed antileishmanial activities against L. major promastigote and amastigote with an IC50 value of 154.1 g/ml (Mirzaei et al 2020).…”

Section: Phytochemical Agentsmentioning

confidence: 99%

Leishmaniasis

2022

Int J Vet Sci

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“…An ethanol extract of Curcuma longa rhizome possessed antimicrobial against Acanthamoeba triangularis , a keratitis-causing protozoan [ 7 , 8 ]. Kelussia odoratissima Mozaff inhibited the growth of the promastigote and amastigote of Leishmania major [ 9 ]. Extracts from Brucea javanica seed and Quercus infectoria nut gall showed antiprotozoal activity against B. hominis [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Antiprotozoal activity of Boesenbergia rotunda (L.) Mansf and Ganoderma lucidum (Fr.) Kart extracts against Blastocystis hominis

et al. 2023

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Background and Aim: Blastocystis hominis is an intestinal protozoan in humans and animals. The parasite causes mild-to-severe intestinal complications, such as diarrhea, in healthy humans and immunocompromised hosts. This study aimed to determine the antiprotozoal activity of Boesenbergia rotunda (L.) Mansf and Ganoderma lucidum (Fr.) Kart extracts against B. hominis. Materials and Methods: Antiprotozoal activity of B. rotunda and G. lucidum extracts against B. hominis subtype 3 was determined using the erythrosin B exclusion assay, confirmed by a time-kill study. The morphology of the parasite treated with the extracts was observed by a scanning electron microscope. The phytochemicals present in B. rotunda and G. lucidum extracts were identified by gas chromatography-mass spectrometry analysis. Results: Both B. rotunda and G. lucidum extracts demonstrated strong antiprotozoal activity with similar minimum inhibitory concentration (MIC) values of 62.5 μg/mL. At 4× MIC and 8× MIC, both B. rotunda and G. lucidum extracts, and metronidazole inhibited the growth of B. hominis by up to 90% after 12 h treatment. Blastocystis hominis cells treated with B. rotunda extract, G. lucidum extract, and metronidazole were deformed and withered when compared with the control. Geraniol and versalide were found as the main compounds in B. rotunda and G. lucidum extracts, respectively. Conclusion: These results indicate the potential medicinal benefits of B. rotunda and G. lucidum extracts in the growth inhibition of B. hominis.

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Butanol Fraction of Kelussia odoratissima Mozaff Inhibits the Growth of Leishmania major Promastigote and Amastigote

Cited by 5 publications

References 0 publications

Green Approach: ‘‘A Forwarding Step for Curing Leishmaniasis—A Neglected Tropical Disease’’

Green Approach: ‘‘A Forwarding Step for Curing Leishmaniasis—A Neglected Tropical Disease’’

Leishmaniasis

Antiprotozoal activity of Boesenbergia rotunda (L.) Mansf and Ganoderma lucidum (Fr.) Kart extracts against Blastocystis hominis

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