Busulfan with 400 centigray of total body irradiation and higher dose fludarabine: An alternative regimen for hematopoietic stem cell transplantation in pediatric acute lymphoblastic leukemia
Jaspreet Gharial,
Gregory Guilcher,
Tony Truong
et al.
Abstract:BackgroundHematopoietic stem cell transplantation can be curative for children with difficult‐to‐treat leukemia. The conditioning regimen utilized is known to influence outcomes. We report outcomes of the conditioning regimen used at the Alberta Children's Hospital, consisting of busulfan (with pharmacokinetic target of 3750 μmol*min/L/day ±10%) for 4 days, higher dose (250 mg/m2) fludarabine and 400 centigray (cGy) of total body irradiation.ProcedureThis retrospective study involved children receiving transpl… Show more
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