Buspirone loaded solid lipid nanoparticles for amplification of nose to brain efficacy: Formulation development, optimization by Box-Behnken design, in-vitro characterization and in-vivo biological evaluation

Yasir, Mohd; Chauhan, Iti; Zafar, Ameeduzzafar; Verma, Madhu; Noorulla, K. M.; Tura, Abdurazak J.; Alruwaili, Nabil K.; Haji, Misbahu J.; Puri, Dinesh; Gobena, Wondesen G.; Dalecha, Debesa D.; Sara, Udai Vir Singh; Kumar, Nitin

doi:10.1016/j.jddst.2020.102164

Cited by 37 publications

(26 citation statements)

References 42 publications

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“…The small value of PDI (＜0.5) indicates the uniform or mono distribution of particles without any aggregation in the developed SLNs dispersion. A similar finding was observed by Yasir et al during the production of Buspirone-loaded SLNs for the nose to brain delivery 32) . Both particle size and surface charge are important in the case of nanoparticles drug delivery.…”

Section: Evaluation Of Particle Size Pdi and Zeta Potentialsupporting

confidence: 87%

“…screening study and pre-optimization of formulation variables For the selection of suitable lipid, surfactant, homogenization speed & time, sonication time, etc., preliminary studies were conducted 32,33) . The selection of suitable lipid depends upon the drug solubility in lipid and selection of surfactant is depending upon the solubility of lipid in surfactant.…”

Section: Preparation and Optimization Of Slns: Preliminarymentioning

confidence: 99%

“…The descending order of OLP solubility/100 gm in different lipid was compritol 188 ATO (36.93±4.92 mg) ＞Precirol ATO 5 (29.37±3.01 mg) ＞GMS (23.84±2.73 mg) ＞palmitic acid (21.41±2.81 mg) ＞stearic acid (16.25±1.65 mg) . Compritol 888 ATO had been used as a lipid for the preparation of oral-based SLNs for the preparation SLNs 32) .…”

Section: Preliminary Screening and Pre-optimization Of Formulation Variablesmentioning

confidence: 99%

“…Increasing the lipid concentration at a constant surfactant level caused the coagulation of particles resulting in a nonuniform particle size distribution. Figure 4 explored the influence of various independent variables on the PDI 32) .…”

Section: In Uence Of Independent Parameters On Pdi (Y3)mentioning

confidence: 99%

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Olive Leaves (Olea europaea L) Extract Loaded Lipid Nanoparticles: Optimization of Processing Parameters by Box-Behnken Statistical Design, in-vitro Characterization, and Evaluation of Anti-oxidant and Anti-microbial Activity

Alnusaire

2021

J. Oleo Sci.

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IntroductionThe Dicotyledons Oleaceae family consists of about 30 genera of deciduous plants including olive trees and it has related around 600 species. Oleaceae members are well grown in topical and sub-temperate reasons of Asia 1) . Olive tree (Olea europaea) oil obtained from different parts like fruit, leaves, etc. has many health benefits upon regular consumption. Traditionally it was used as a folk medicine for remedying various types of fevers and other problems associated with body 2) .Olive leaves extract exhibited several therapeutics activities like anti-hypertensive, hypoglycemic, antimicrobial, hypouricemic, etc

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Section: Evaluation Of Particle Size Pdi and Zeta Potentialsupporting

confidence: 87%

Section: Preparation and Optimization Of Slns: Preliminarymentioning

confidence: 99%

Section: Preliminary Screening and Pre-optimization Of Formulation Variablesmentioning

confidence: 99%

Section: In Uence Of Independent Parameters On Pdi (Y3)mentioning

confidence: 99%

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Olive Leaves (Olea europaea L) Extract Loaded Lipid Nanoparticles: Optimization of Processing Parameters by Box-Behnken Statistical Design, in-vitro Characterization, and Evaluation of Anti-oxidant and Anti-microbial Activity

Alnusaire

2021

J. Oleo Sci.

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“…A graph of the amount of drug permeated versus time was plotted. The different parameters i.e., flux (J, µg/cm 2 /h), permeability coefficient (PC) and enhancement ratio (ER) were calculated using the following equations [27,30]:…”

Section: Ex-vivo Permeation Studymentioning

confidence: 99%

Formulation of Self-Nanoemulsifying Drug Delivery System of Cephalexin: Physiochemical Characterization and Antibacterial Evaluation

et al. 2022

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A cephalexin (CEP) self-nanoemulsifying drug delivery system (SNEDDS) was developed in this study to improve the drug’s oral administration. The CEP-SNEDDS was made utilizing an aqueous titration method employing Lauroglycol 90, Poloxamer 188, and Transcutol-HP. Box-Behnken design (BBD) with three factors at three levels was used for optimization, and their impacts on globule size (nm), transmittance (percent), and emulsification time (s) were assessed. The optimized formulation (Opt-F3) was further tested for zeta potential, refractive index, percent transmittance, thermodynamic stability, in-vitro release, ex vivo permeability, antibacterial activity, and bioavailability. The chosen formulation (Opt-F3) had a globule size of 87.25 ± 3.16 nm, PDI of 0.25, zeta potential of −24.37 mV, self-emulsification duration of 52 ± 1.7 s, and percentage transmittance of 99.13 ± 1.5%, viscosity of 96.26 ± 2.72 cp, and refractive index of 1.29 ± 0.1. It showed a sustained release profile (94.28 ± 5.92 percent in 24 h). The Opt-F3 formulation had 3.95 times the permeability of CEP-dispersion. In comparison to CEP-dispersion, it also demonstrated greater antibacterial efficacy against tested Gram-positive and Gram-negative pathogens. The oral bioavailability of Opt-F3 is 3.48 times higher than that of CEP-dispersion, according to an in-vivo investigation. It has been determined that the prepared CEP-SNEDDS may be an advantageous carrier for CEP delivery.

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Nose-to-Brain Drug Delivery Strategies for the Treatment of Neurological Disorders

Bhatane,

Alexander

2023

Drug Delivery Strategies in Neurological Disorders: Challenges and Opportunities

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Buspirone loaded solid lipid nanoparticles for amplification of nose to brain efficacy: Formulation development, optimization by Box-Behnken design, in-vitro characterization and in-vivo biological evaluation

Cited by 37 publications

References 42 publications

Olive Leaves (<i>Olea europaea</i> L) Extract Loaded Lipid Nanoparticles: Optimization of Processing Parameters by Box-Behnken Statistical Design, <i>in-vitro</i> Characterization, and Evaluation of Anti-oxidant and Anti-microbial Activity

Olive Leaves (<i>Olea europaea</i> L) Extract Loaded Lipid Nanoparticles: Optimization of Processing Parameters by Box-Behnken Statistical Design, <i>in-vitro</i> Characterization, and Evaluation of Anti-oxidant and Anti-microbial Activity

Formulation of Self-Nanoemulsifying Drug Delivery System of Cephalexin: Physiochemical Characterization and Antibacterial Evaluation

Nose-to-Brain Drug Delivery Strategies for the Treatment of Neurological Disorders

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