Buspirone improves 6-hydroxydopamine-induced catalepsy through stimulation of nigral 5-HT1A receptors in rats

Nayebi, Alireza Mohajjel; Rad, S Reyhani; Saberian, Mehdi; Azimzadeh, Saeid; Samini, Morteza

doi:10.1016/s1734-1140(10)70264-4

Cited by 32 publications

(20 citation statements)

References 29 publications

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“…This is in accordance with results of our previous studies concerning an anti-cataleptic effect for 5-HT 1A agonists in 6-OHDA (11) and haloperidole (12) induced PD.…”

Section: Discussionsupporting

confidence: 93%

“…Stimulation of 5-HT 1A receptors in these regions leads to dopamine release (9) via inhibition of adenyl cyclase and opening of potassium channels (10). Recently it was shown that 5-HT 1A agonists exert anti-cataleptic effect in animal model of PD (11, 12) and also regulatory effect of 5-HT 1A receptors on L-DOPA derived dopamine levels has been reported (13). However there is no report about 5-HT 1A effects on anti-cataleptic effect of L-DOPA.…”

Section: Introductionmentioning

confidence: 99%

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Buspirone improves the anti-cataleptic effect of levodopa in 6-hydroxydopamine-lesioned rats

Mahmoudi

Nayebi

Samini

et al. 2011

Pharmacological Reports

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In Parkinson's disease (PD), prolonged exposure to L-3,4-dihydroxyphenylalanine (L-DOPA) results in motor fluctuations, such as the on-off phenomenon, and L-DOPA-induced dyskinesia. Previously, we found that activation of 5-HT(1A) in the substantia nigra pars compacta (SNc) decreased catalepsy in parkinsonian rats. In the current investigation, we attempted to evaluate the effect of buspirone on the anti-cataleptic effect of L-DOPA in 6-hydroxydopamine (6-OHDA)-lesioned male Wistar rats. Catalepsy was induced by the unilateral infusion of 6-OHDA (8 μg/2 μl/rat) into the central region of the SNc. After a 3-week recovery period, rats received L-DOPA intraperitoneally (ip; 15 mg/kg) twice daily for 20 days, and the anti-cataleptic effect of L-DOPA was assessed by the bar test at days 5, 10, 15 and 20. The results showed that L-DOPA had an anti-cataleptic effect only until day 15, and its effect was abolished on day 20. On day 21, these rats were co-treated with three different doses of buspirone (0.1, 0.5 and 2.5 mg/kg, ip) and L-DOPA (15 mg/kg, ip). At a dose of 0.5 mg/kg, buspirone improved the anti-cataleptic effect of L-DOPA. Furthermore, the effect of buspirone (0.5 mg/kg, ip) on the anti-cataleptic effect of L-DOPA (15 mg/kg, ip) was reversed by 1-(2-methoxyphenyl)-4-(4-phthalimidobutyl)piperazine hydrobromide (NAN-190; 0.5 mg/kg, ip), a 5-HT(1A) receptor antagonist. From these results, it may be concluded that buspirone improves the anti-cataleptic effect of L-DOPA in a 6-OHDA-induced animal model of PD through the activation of 5-HT(1A) receptors. In this regard, further investigations should be undertaken to clarify the exact mechanism of the interaction between 5-HT(1A) and dopaminergic neurons.

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“…This is in accordance with results of our previous studies concerning an anti-cataleptic effect for 5-HT 1A agonists in 6-OHDA (11) and haloperidole (12) induced PD.…”

Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Buspirone improves the anti-cataleptic effect of levodopa in 6-hydroxydopamine-lesioned rats

Mahmoudi

Nayebi

Samini

et al. 2011

Pharmacological Reports

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“…In addition to the wood block test, the standard bar test has also been routinely used for the measurement of cataleptic side effects of neuroleptic drugs (Nayebi et al, 2010). The apparatus consists of a bar placed horizontally several centimeters above the floor of a test box.…”

Section: Bar Testmentioning

confidence: 99%

Antipsychotic activity of standardizedBacopaextract against ketamine-induced experimental psychosis in mice: Evidence for the involvement of dopaminergic, serotonergic, and cholinergic systems

Chatterjee

Verma

Kumari

et al. 2015

Pharmaceutical Biology

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(2015) Antipsychotic activity of standardized Bacopa extract against ketamine-induced experimental psychosis in mice: Evidence for the involvement of dopaminergic, serotonergic, and cholinergic systems, Pharmaceutical Biology, 53:12, 1850-1860, DOI: 10.3109/13880209.2014 (40, 80, and 120 mg/kg, p.o.) were given to the mice 1 h prior to ketamine administration and tested for positive symptoms and cognitive deficits. A chronic ketamine treatment regimen was used to study the effect of BM on negative symptoms such as immobility enhancement. Each mouse was used once for the behavioral studies.Results: BM reduced ketamine-induced hyperactivity with an EC 50 value of 76.60 mg/kg. The 80 mg/kg dose was used for all other behavior analysis. Pretreatment with BM at 80 mg/kg showed two-fold increases in transfer latency time (TLT) in passive avoidance task. Chronic BM pretreatment (80 mg/kg p.o. daily Â 10 d) ameliorated the ketamine-induced enhanced immobility effect by 21% in the forced swim test. BM treatment reversed ketamine-induced increase in monoamine oxidase activity in both cortex and striatum and normalized the acetylcholinesterase activity and the glutamate levels in the hippocampus. Discussion and conclusion: Overall our findings suggest that BM possesses antipsychotic properties which might be due to its modulatory action on dopamine, serotonin, and glutamate neurotransmission.

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“…The standard bar test has been routinely used for measurement of catalapetic side effects of neuroleptic drugs [20]. The bar test consists of a bar kept horizontally several centimetres above the floor of a test box.…”

Section: Bar Testmentioning

confidence: 99%

Evaluation of the Antipsychotic Potential of Panax quinquefolium in Ketamine Induced Experimental Psychosis Model in Mice

et al. 2011

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The search for novel pharmacotherapy from medicinal plants for psychiatric illnesses has progressed significantly from the past few decades and their therapeutic potential has been assessed in a variety of animal models. The aim of our study was to screen one such plant, Panax quinquefolium (PQ), with significant neuroactive properties for its antipsychotic potential. A graded dose study with PQ at 12.5-200 mg/kg, p. o. showed differential effects against the ketamine induced hyperactivity in the Digiscan animal activity monitor. Nevertheless at 100 mg/kg, p.o., PQ blocked ketamine induced memory impairment in the passive avoidance paradigm. In the chronic studies, PQ reduced the ketamine induced enhanced immobility in the forced swim test and did not show extra-pyramidal side effects in bar test and wood block test of catalepsy. These behavioural effects were compared with standard drugs haloperidol and clozapine. Further PQ reduced DA and 5-HT content after chronic treatment, but not after acute administration. In addition, PQ extract reduced acetylcholinesterase activity and nitrate levels, however increased glutamate levels in hippocampus. Overall our findings suggest that PQ possess antipsychotic like properties, which may leads to future studies with its specific constituents which may particularly be beneficial in predominant negative and cognitive symptoms of schizophrenia.

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Buspirone improves 6-hydroxydopamine-induced catalepsy through stimulation of nigral 5-HT1A receptors in rats

Cited by 32 publications

References 29 publications

Buspirone improves the anti-cataleptic effect of levodopa in 6-hydroxydopamine-lesioned rats

Buspirone improves the anti-cataleptic effect of levodopa in 6-hydroxydopamine-lesioned rats

Antipsychotic activity of standardizedBacopaextract against ketamine-induced experimental psychosis in mice: Evidence for the involvement of dopaminergic, serotonergic, and cholinergic systems

Evaluation of the Antipsychotic Potential of Panax quinquefolium in Ketamine Induced Experimental Psychosis Model in Mice

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