Buruli Ulcer: Case Study of a Neglected Tropical Disease

Benbow, M. Eric; Simmonds, Rachel E.; Merritt, Richard W.; Jordan, Heather R.

doi:10.1007/978-3-319-60616-3_5

Cited by 1 publication

(1 citation statement)

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“…Finally, it is important to note that One Health aspects and the associated knowledge gaps should be considered when setting programmatic targets for these diseases. While proclamation of ambitious control and/or elimination targets in all three diseases indisputably have created the necessary momentum among global health stakeholders for improved and more coordinated disease control efforts, it is more evident that without thorough assessment and profound understanding of all potential transmission chains and subsequent tailoring of public health interventions, feasibility of the set milestones is highly questionable [76,93,94]. Current evidence rather suggests that reduction in transmission cannot be expected to be accomplished solely by actions or interventions in the human healthcare domain, as the underlying transmission mechanisms in all three diseases are complex, likely involving multiple cross-species transmission and sapronotic routes, spillover and spillback phenomena and thus requiring rather comprehensive One-Health solutions [95].…”

Section: Discussionmentioning

confidence: 99%

Buruli ulcer, tuberculosis and leprosy: Exploring the One Health dimensions of three most prevalent mycobacterial diseases: A narrative review

Spiliopoulos,

Solomos,

Puchner

2024

Tropical Med Int Health

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AbstractΟbjectivesAlthough Buruli ulcer, tuberculosis, and leprosy are the three most common mycobacterial diseases, One Health dimensions of these infections remain poorly understood. This narrative review aims at exploring the scientific literature with respect to the presence of animal reservoir(s) and other environmental sources for the pathogens of these infections, their role in transmission to humans and the research on/practical implementation of One Health relevant control efforts.MethodsThe literature review was conducted using the online databases PubMed, Scopus, ProQuest and Google Scholar, reviewing articles that were written in English in the last 15 years. Grey literature, published by intergovernmental agencies, was also reviewed.ResultsFor the pathogen of Buruli ulcer, evidence suggests possums as a possible animal reservoir and thus having an active role in disease transmission to humans. Cattle and some wildlife species are deemed as established animal reservoirs for tuberculosis pathogens, with a non‐negligible proportion of infections in humans being of zoonotic origin. Armadillos constitute an established animal reservoir for leprosy pathogens with the transmission of the disease from armadillos to humans being deemed possible. Lentic environments, soil and other aquatic sources may represent further abiotic reservoirs for viable Buruli ulcer and leprosy pathogens infecting humans. Ongoing investigation and implementation of public health measures, targeting (sapro)zoonotic transmission can be found in all three diseases.ConclusionBuruli ulcer, tuberculosis and leprosy exhibit important yet still poorly understood One Health aspects. Despite the microbiological affinity of the respective causative mycobacteria, considerable differences in their animal reservoirs, potential environmental sources and modes of zoonotic transmission are being observed. Whether these differences reflect actual variations between these diseases or rather knowledge gaps remains unclear. For improved disease control, further investigation of zoonotic aspects of all three diseases and formulation of One Health relevant interventions is urgently needed.

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Section: Discussionmentioning

confidence: 99%