Buruli Ulcer: Advances in Understanding Mycobacterium ulcerans Infection

Walsh, Douglas S.; Portaels, Françoise; Meyers, Wayne M.

doi:10.1016/j.det.2010.09.006

Cited by 79 publications

(79 citation statements)

References 49 publications

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“…1,8,24,30,60 This has led to improved therapy, 61,62 as well as identification of possible candidates for vaccination and diagnosis. 26,28,51 However, many questions remain to be answered, such as the relative importance of humoral and cellular immune responses in controlling the infection.…”

Section: Discussionmentioning

confidence: 99%

“…BU has been documented in over 30 countries worldwide, although most of the cases occur in West Africa, primarily Benin, Côte d'Ivoire and Ghana. 1 According to the World Health Organization (apps.who.int/neglected_diseases/ntddata/ buruli/buruli.html), there were 4,888 new BU cases reported in 2010, primarily in children under 15 years. However, as the disease is not notifiable in many countries and most patients live in remote, rural areas with little medical infrastructure, the actual number of cases is likely to be much higher.…”

Section: Introductionmentioning

confidence: 99%

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Buruli ulcer

Einarsdottir¹,

Huygen²

2011

Human Vaccines

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Buruli ulcer

Einarsdottir¹,

Huygen²

2011

Human Vaccines

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“…Cameroon [3]. In some parts of Cote d'Ivoire, Ghana and Benin Republic, Buruli ulcer incidence has overtaken tuberculosis and leprosy as the most common [4].…”

Section: Buruli Ulcer Disease (Bud) Which Is Caused Bymentioning

confidence: 99%

Presumptive Diagnosis of Buruli Ulcer based on Clinical Presentations

Oluniyi¹

2017

Journal of Microbiology and Infectious Diseases

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Objectives: Buruli ulcer disease (BUD) is a neglected tropical disease of the skin, subcutaneous tissue and occasionally bone. Except in endemic areas, the diagnosis of BUD can be a challenge. This study was an attempt to presumptively identify cases of Buruli ulcer in the absence of a laboratory confirmation. Methods:A presumptive diagnosis of Buruli ulcer by directly comparing clinical presentations with WHO-confirmed pictorial images of the disease was carried out on patients with suspected Buruli ulcers presenting to two government-owned hospitals in Ogun State, South-West, Nigeria.Results: Eighteen suspected cases of BUD from as many outpatients were identified within a three-month period, comprising 13 (72.2%) females and five (27.8%) males. 10 (55.6%) and eight (44.4%) of them were from the tertiary and secondary health facilities, respectively. Eleven (61%) of the ulcers were located on the leg, four (22%) on the breast and four (22%) on the hand. 14 (77.8%) of the patients were above 40 years of age, two (11.1%) were between 18 and 30 years while only two (11.1%) were below 15 years. 16 (89%) of the patients could not remember how the ulcer started while two (11%) of them said their lesions started with a scratch. 7(39%) of the ulcers were painless; 11 (61%) were minimally painful while 15 (83%) had undermined edges which are presentations consistent with Buruli ulcer disease. Conclusions:The detection of these ulcers in just two hospitals and within a period of three months is significant and suggestive of Buruli ulcer being probably more prevalent in South-west Nigeria than aforethought. J Microbiol Infect Dis 2017; 7(1): 36-41

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“…Though the mode of transmission of M. ulcerans is not yet known, the spread of the disease has been suggested to be influenced by local environmental factors such as the presence of rivers, lakes and swampy areas, and through exposed wounds [5,6]. It also survives and thrives in temperature range between 28-34°C [6].…”

Section: Introductionmentioning

confidence: 99%

“…BU is a chronic, devastating and necrotizing skin disease caused by a toxin-producing bacterium known as Mycobacterium ulcerans (M. Ulcerans) [1,[3][4][5]. It is one of the most neglected but treatable tropical diseases mostly found in rural areas located near wetlands or rivers [6].…”

Section: Introductionmentioning

confidence: 99%

Geospatial Analysis of Buruli Ulcer Prevalence in Anambra North, Anambra State, Nigeria

Ike¹,

Usman²,

Yelwa³

2017

J Prev Inf Cntrl

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Although the true burden and the factors responsible for Buruli ulcer (BU) occurrence in Nigeria is not yet known, the disease has become an issue of great concern in some parts of the country, especially in Anambra State. It is against this background that this study analyzed the prevalence of BU in Anambra North with the objectives of determining the hotspots, trends and factors influencing the occurrence of the disease in the study area. Three LGAs and fifteen communities were selected based on purposive sampling in which 400 copies of questionnaire were randomly distributed. Field survey, topographic map of the study area, administrative map of the study area, Global Position System (GPS) and Google earth satellite images were the materials and methods used for the study. The analysis was done using ArcGIS 10.1 and Excel software packages. The results show a variation in the temporal distribution of the disease. The trend analysis revealed that the months of February and May recorded the highest number of cases of BU (17.2%) and (15.6%), respectively while the months of September and October recorded no case of the disease. The study also discovered five significant hotspots of BU at 95% confidence level using the Getis-Ord G * tool. The hotspots of BU in the study area include Omor (p-value: 0.0119), Umumbo (0.0119), Igbakwu (p-value: 0.0119), Anaku (p-value: 0.0197) and Umuerum (p-value: 0.0197). On the factors influencing BU occurrence in the study area, cultural practices, farming/fishing on swampy lands, swimming in rivers and living close to stagnant bodies of water were identified as risk factors of BU occurrence in the study area. The bivariate analysis of BU factors revealed that cultural practices pose the highest risk of BU occurrence with a percentage increase in risk of 846% while wearing of protective gadgets reduces the risk of the disease with a percentage decrease in risk of 20%. More so, the study showed that the disease has negative effects on the feeding habit and employment of majority (76.6%) and (78.1%) respectively of the affected persons. The study therefore concludes by recommending that people should be discouraged from activities around the ox-bow lakes such as swimming and dipping legs in pond waters.

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Buruli Ulcer: Advances in Understanding Mycobacterium ulcerans Infection

Cited by 79 publications

References 49 publications

Buruli ulcer

Buruli ulcer

Presumptive Diagnosis of Buruli Ulcer based on Clinical Presentations

Geospatial Analysis of Buruli Ulcer Prevalence in Anambra North, Anambra State, Nigeria

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