Burst valves for commercial microfluidics: a critical analysis

Bauer, Maria; Ataei, Marzieh; Caicedo, Maria; Jackson, K. L.; Madou, Marc; Bousse, Luc

doi:10.1007/s10404-019-2252-8

Cited by 19 publications

(20 citation statements)

References 22 publications

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“…This is likely due to a combination of inherent surface topography and hydrophobicity, thus affecting capillary forces in the channel. Furthermore it can be seen that burst frequency increases steeply at very small channel widths, as described in the burst valve theory discussed in Bauer et al [20].…”

Section: Resultsmentioning

confidence: 83%

“…As can be seen from Table 1, surface contact with support material (i.e., matte surface finish) during the printing process not only affects the surface roughness but also the contact angles. The static contact angle for matte, as compared to glossy finish, is more hydrophobic, thus contributing to higher burst pressures for the same channel geometries (compare Figure 6d) [20]. The effect of the support material on the surface topography of the part can be gleaned from Figure 5.…”

Section: Resultsmentioning

confidence: 99%

“…While 3D printing is only appropriate for prototyping of CD inserts rather than mass manufacturing due to its sequential nature of producing parts, material jetting of a flexible and a rigid material can be used to model products before investing in a costly mold. Printed surfaces were fluidically evaluated as differences in surface properties need to be considered when utilizing a prototyping approach to correctly predict fluidic behavior of manufactured parts [20]. The surface finish of the printed parts not only impacts hydrophilicity and topography but also the smallest possible dimensions with matte surface finish, allowing for more accurate features, while the glossy surface finish yields higher hydrophilicity and better bonding with adhesives.…”

Section: Discussionmentioning

confidence: 99%

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3D Printing of Elastic Membranes for Fluidic Pumping and Demonstration of Reciprocation Inserts on the Microfluidic Disc

et al. 2019

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While 3D printing is increasingly used in most fields of engineering, its utilization for microfluidics has thus far been limited. To demonstrate future applications of 3D printing for microfluidic structures, we investigate the fluidic characteristics of material jetted surfaces. We also demonstrate the manufacture of dual-material microfluidic inserts that feature rigid and elastic elements. The fabricated parts are inserted on a microfluidic CD, enhancing design freedom and prototyping capability of over molded parts. Furthermore, printed elastic membranes are tested for fatigue during elastic-pneumatic pumping and rigid and elastic surfaces are characterized with regards to hydrophilicity and surface topography. Finally, different printed disc inserts are demonstrated for moving liquid towards the center of rotation, the mixing of liquids, and controlling burst events through channels width.

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Section: Resultsmentioning

confidence: 83%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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3D Printing of Elastic Membranes for Fluidic Pumping and Demonstration of Reciprocation Inserts on the Microfluidic Disc

et al. 2019

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“…To overcome the capillary pressure across the capillary valve placed between the metering chamber and the dilution chamber, the device was spun at an angular velocity, ω, higher than the burst angular velocity, ω b : ω > ω b . The driving pressure due to the centrifugal force, ∆P d , exerted on the liquid column, whose advancing front-end and receding rear-end are located at distances r A and r R from the rotation center, can be described as below [39]:…”

Section: Transfer Of Metered Liquids Into Dilution Chambersmentioning

confidence: 99%

An Integrated Centrifugal Degassed PDMS-Based Microfluidic Device for Serial Dilution

et al. 2021

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We propose an integrated serial dilution generator utilizing centrifugal force with a degassed polydimethylsiloxane (PDMS) microfluidic device. Using gas-soluble PDMS as a centrifugal microfluidic device material, the sample can be dragged in any arbitrary direction using vacuum-driven force, as opposed to in a single direction, without adding further actuation components. The vacuum-driven force allows the device to avoid the formation of air bubbles and exhibit high tolerance in the surface condition. The device was then used for sample metering and sample transferring. In addition, centrifugal force was used for sample loading and sample mixing. In this study, a series of ten-fold serial dilutions ranging from 100 to 10−4 with about 8 μL in each chamber was achieved, while the serial dilution ratio and chamber volume could easily be altered by changing the geometrical designs of the device. As a proof of concept of our hybrid approach with the centrifugal and vacuum-driven forces, ten-fold serial dilutions of a cDNA (complementary DNA) sample were prepared using the device. Then, the diluted samples were collected by fine needles and subject to a quantitative polymerase chain reaction (qPCR), and the results were found to be in good agreement with those for samples prepared by manual pipetting.

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“…Using liquids as functional materials to control flow has offered a different route to design the inner surface of microchannels by transforming the basic scientific issues of solid–liquid interfaces to solid–liquid–liquid interfaces. Interface phenomena and microscale flow control in microchannels, such as liquid–liquid interfaces in two phase flow (droplet microfluidics), solid–liquid interfaces for droplet motion on micro‐/nanostructures (open microfluidics), and fabrication of microflow control units, have been described in detail, and will not be considered in this review.…”

Section: Introductionmentioning

confidence: 99%

Inner Surface Design of Functional Microchannels for Microscale Flow Control

Wang

Yang

et al. 2019

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Fluidic flow behaviors in microfluidics are dominated by the interfaces created between the fluids and the inner surface walls of microchannels. Microchannel inner surface designs, including the surface chemical modification, and the construction of micro‐/nanostructures, are good examples of manipulating those interfaces between liquids and surfaces through tuning the chemical and physical properties of the inner walls of the microchannel. Therefore, the microchannel inner surface design plays critical roles in regulating microflows to enhance the capabilities of microfluidic systems for various applications. Most recently, the rapid progresses in micro‐/nanofabrication technologies and fundamental materials have also made it possible to integrate increasingly complex chemical and physical surface modification strategies with the preparation of microchannels in microfluidics. Besides, a wave of researches focusing on the ideas of using liquids as dynamic surface materials is identified, and the unique characteristics endowed with liquid–liquid interfaces have revealed that the interesting phenomena can extend the scope of interfacial interactions determining microflow behaviors. This review extensively discusses the microchannel inner surface designs for microflow control, especially evaluates them from the perspectives of the interfaces resulting from the inner surface designs. In addition, prospective opportunities for the development of surface designs of microchannels, and their applications are provided with the potential to attract scientific interest in areas related to the rapid development and applications of various microchannel systems.

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Burst valves for commercial microfluidics: a critical analysis

Cited by 19 publications

References 22 publications

3D Printing of Elastic Membranes for Fluidic Pumping and Demonstration of Reciprocation Inserts on the Microfluidic Disc

3D Printing of Elastic Membranes for Fluidic Pumping and Demonstration of Reciprocation Inserts on the Microfluidic Disc

An Integrated Centrifugal Degassed PDMS-Based Microfluidic Device for Serial Dilution

Inner Surface Design of Functional Microchannels for Microscale Flow Control

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