2009
DOI: 10.1371/journal.pone.0005040
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Burst of Young Retrogenes and Independent Retrogene Formation in Mammals

Abstract: Retroposition and retrogenes gain increasing attention as recent studies show that they play an important role in human new gene formation. Here we examined the patterns of retrogene distribution in 8 mammalian genomes using 4 non-mammalian genomes as a contrast. There has been a burst of young retrogenes not only in primate lineages as suggested in a recent study, but also in other mammalian lineages. In mammals, most of the retrofamilies (the gene families that have retrogenes) are shared between species. In… Show more

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Cited by 45 publications
(46 citation statements)
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References 48 publications
(88 reference statements)
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“…Most of these show low divergence at synonymous sites compared with their parental gene (d S ∼ 0.1) (Supplemental Fig. S1; Supplemental Table S1), suggesting that they emerged relatively recently during mammalian evolution (Marques et al 2005;Pan and Zhang 2009). In contrast, we found fewer retrocopies in the genomes of platypus and chicken, consistent with the lack of LINE-1 activity in these lineages (Hillier et al 2004;Warren et al 2008;Kaessmann et al 2009).…”
Section: Annotation and Transcriptional Profiling Of Retrocopies In 1mentioning
confidence: 99%
“…Most of these show low divergence at synonymous sites compared with their parental gene (d S ∼ 0.1) (Supplemental Fig. S1; Supplemental Table S1), suggesting that they emerged relatively recently during mammalian evolution (Marques et al 2005;Pan and Zhang 2009). In contrast, we found fewer retrocopies in the genomes of platypus and chicken, consistent with the lack of LINE-1 activity in these lineages (Hillier et al 2004;Warren et al 2008;Kaessmann et al 2009).…”
Section: Annotation and Transcriptional Profiling Of Retrocopies In 1mentioning
confidence: 99%
“…Other studies have also shown that there is an excess of X-linked parental genes (genes which give rise to retrocopies) in both mammals and flies [13,14,22], a possible result of meiotic X chromosome inactivation (XCI) [27]. However, it is still at the early stage to compare the evolutionary pattern of retrocopies among primates at a genome-wide scale [16,28], therefore a systematic comparative study is desirable to leverage our knowledge on primate genome evolution, lineage-specific adaptations, and fine time scales of genomic changes [29,30]. Thus, I exploited four fully sequenced primate genomes, human (Homo sapiens) [31], chimpanzee (Pan troglodytes) [32], orangutan (Pongo pygmaeus) [33], and macaque (Macaca mulatta) [34]) to study the evolutionary pattern of retropositions in primates.…”
Section: Introductionmentioning
confidence: 99%
“…As a copy mechanism to generate new genes (Brosius, 1991;Kaessmann et al, 2009), retroposition is widely observed in animals, such as in mammals or Drosophila (Drosophila melanogaster; Betrán et al, 2002;Emerson et al, 2004;Pan and Zhang, 2009). In contrast, knowledge of retrogenes in plants is so far limited.…”
mentioning
confidence: 99%