Burst of Autoimmunity with the Emergence of Primary Sjogren Syndrome, Cholestatic Autoimmune Hepatitis and Latent Autoimmune Diabetes of Adults (LADA)

Kocaman, Orhan; Aygün, Cem; Gurbuz, Yesim; Çefle, Ayşe; Konduk, Tolga; Şentürk, Ömer; Çelebi, Altay; Hülagü, Sadettin

doi:10.1097/01.smj.0000235468.62509.5b

Cited by 4 publications

(2 citation statements)

References 5 publications

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“…A nationwide survey in Japan indicated that SS is present in 10% of patients with AIH,11 although the exact prevalence of AIH in patients with pSS is unclear. Kocaman et al12 reported a case showing the symptoms and findings of pSS, cholestatic AIH, and latent autoimmune diabetes in adult (LADA) at the same time. In addition, the patient had experienced dry mouth and dry eyes for 6 months before the development of jaundice.…”

Section: Discussionmentioning

confidence: 99%

Co-development of autoimmune hepatitis and Sjögren's syndrome triggered by the administration of herbal medicines

Mok

Baek

et al. 2013

Clin Mol Hepatol

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Autoimmune hepatitis (AIH) has been reported in association with Sjögren's syndrome (SS). Drug-induced AIH has been rarely reported. A rare case of the co-development of AIH and SS in a 53-year-old woman after the consumption of herbal medicines is described. After admission, the patient complained of dryness in her mouth, and she was subsequently diagnosed with SS, which had not been detected previously. The patient's bilirubin and aminotransferase levels initially decreased following conservative management; however, they later began to progressively increase. A diagnosis of AIH was made based on the scoring system proposed by the International Autoimmune Hepatitis Group. The patient was administered a combination of prednisolone and azathioprine, and the results of follow-up liver-function tests were found to be within the normal range. This is an unusual case of AIH and SS triggered simultaneously by the administration of herbal medicines.

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Section: Discussionmentioning

confidence: 99%

Co-development of autoimmune hepatitis and Sjögren's syndrome triggered by the administration of herbal medicines

Mok

Baek

et al. 2013

Clin Mol Hepatol

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“…Cases have been reported in which a common triggering event for both diabetes and DES was postulated [14]. Others have shown the concomitant occurrence of several autoimmune problems, highlighting the possibility that the association of autoimmune diabetes and DES was linked to a common autoimmune target [15,16]. The first large clinical study designed to compare the symptoms, signs, and results of objective tests for DES in T1D patients and controls was undertaken recently [4].…”

Section: Discussionmentioning

confidence: 99%

Diabetes-Associated Dry Eye Syndrome in a ‘Humanized’ Transgenic Model of Type 1 Diabetes.

Elagin¹,

Jaume²

2010

The Endocrine Society's 92nd Annual Meeting, June 19–22, 2010 - San Diego

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Patients with diabetes are at significant risk of developing corneal lesions, such as superficial punctuate keratitis, recurrent corneal erosions, persistent epithelial defects, and microbial keratitis. These lesions are all due to lacrimal gland dysfunction [1]. Even proliferative diabetic retinopathy appears to have a more severe course in patients with diabetes and declined tear film function [2]. Whether or not lacrimal gland dysfunction is metabolic or autoimmune in origin is still controversial [3]. Proliferative and non-proliferative retinopathies are metabolic complications of diabetes. These metabolic complications are caused by microangiopathy, the severity of which in turn determines the development of retinopathy as well as nephropathy and neuropathy. However, a causative relationship between metabolic complications of diabetes and non-retinal ocular disease (i.e., lacrimal dysfunction) is not well established. On the contrary, evidence exists for the association between "tear film" dysfunction (characteristic of diabetes-associated dry eye disease) and autoimmune diabetes [4]. Studies have recently established that the prevalence of symptoms, signs, and definitive diagnosis of dry eye syndrome (DES) are higher, and basal tear secretion and tear film stability are lower, in children with autoimmune (type 1) diabetes mellitus (T1D), years before metabolic complications are even expected [4]. Animal models of autoimmune diabetes have provided the strongest evidence for a causative relationship between autoimmunity and diabetes-associated DES. Non-obese diabetic (NOD) mice, the classic model of human T1D, usually develop lacrimal gland dysfunction. Autoimmune lymphocytic infiltration of lacrimal glands accompanies lymphocytic infiltration of pancreatic islets in NOD mice [5]. A possible explanation for this association of pancreatic islets and lacrimal gland lymphocytic attacks has been based on the existence of cross-reactive antigens in both glands. Recently, a special group of CD4+ helper T cells was observed to be enriched in the inflamed pancreas and salivary glands of NOD mice as well as in the circulation of Sjögren's syndrome patients [6].

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Treatment Side Effects and Associated Autoimmune Diseases

Levy

2011

Autoimmune Hepatitis

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Burst of Autoimmunity with the Emergence of Primary Sjogren Syndrome, Cholestatic Autoimmune Hepatitis and Latent Autoimmune Diabetes of Adults (LADA)

Cited by 4 publications

References 5 publications

Co-development of autoimmune hepatitis and Sjögren's syndrome triggered by the administration of herbal medicines

Co-development of autoimmune hepatitis and Sjögren's syndrome triggered by the administration of herbal medicines

Diabetes-Associated Dry Eye Syndrome in a ‘Humanized’ Transgenic Model of Type 1 Diabetes.

Treatment Side Effects and Associated Autoimmune Diseases

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