Burns Induce Alterations in the Acyl Proteome of Mice and Humans
Shayahati Bieerkehazhi,
Dalia Barayan,
Fadi Khalaf
et al.
Abstract:Hypermetabolic reprogramming triggered by thermal injury causes substantial morbidity and mortality. Despite the therapeutic potential of targeting this response, the underlying mechanisms remain poorly understood. Interestingly, protein S-acylation is a reversible post-translational modification induced by metabolic alterations via DHHC acyltransferases. While this modification aids in the regulation of cellular functions, deregulated S-acylation contributes to various diseases by altering protein structure, … Show more
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