Burning the largest immune organ

Allgöwer, M.; Schoenenberger, G. A.; Sparkes, B. G.

doi:10.1016/0305-4179(95)90028-4

Cited by 105 publications

(31 citation statements)

References 143 publications

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“…6,7 The skin constitutes the body's largest immune organ, thus a thermal injury clearly influences immune competence and resistance against infection and inflammation. 8 Although the release of inflammatory cytokines may be beneficial in stimulating immune defense mechanisms, its influence, when overexpressed, may be detrimental. It has been suggested that the prolonged and increased inflammation associated with burn trauma inhibits burn wound healing and the recovery process.…”

Section: Introductionmentioning

confidence: 99%

Liposomal IGF-1 gene transfer modulates pro- and anti-inflammatory cytokine mRNA expression in the burn wound

et al. 2001

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Section: Introductionmentioning

confidence: 99%

Liposomal IGF-1 gene transfer modulates pro- and anti-inflammatory cytokine mRNA expression in the burn wound

et al. 2001

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“…The former is packed with keratinocytes that make up a mechanical barrier whereas the latter contains capillaries and a variety of immune cells including Langerhans cells, dendritic cells, and macrophages. When skin is damaged by burn injuries the mechanical barrier is ruptured resulting in a complex interplay between pro-and anti-inflammatory responses that create an ideal milieu for bacterial invasion (12)(13)(14)(15)(16)(17). The local inflammatory responses include a dynamic response by epithelial cells and keratinocytes, which modulates antimicrobial peptide gene expression (18) and orchestrate the diapedesis of neutrophils.…”

mentioning

confidence: 99%

Deficiency of Mannose-Binding Lectin Greatly Increases Susceptibility to Postburn Infection withPseudomonas aeruginosa

Møller-Kristensen

Ip²,

Shi³

et al. 2006

The Journal of Immunology

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Burn injury disrupts the mechanical and biological barrier that the skin presents against infection by symbionts like the Pseudomonas aeruginosa, a Gram-negative bacteria. A combination of local factors, antimicrobial peptides, and resident effector cells form the initial response to mechanical injury of the skin. This activity is followed by an inflammatory response that includes influx of phagocytes and serum factors, such as complement and mannose-binding lectin (MBL), which is a broad-spectrum pattern recognition molecule that plays a key role in innate immunity. A growing consensus from studies in humans and mice suggests that lack of MBL together with other comorbid factors predisposes the host to infection. In this study we examined whether MBL deficiency increases the risk of P. aeruginosa infection in a burned host. We found that both wild-type and MBL null mice were resistant to a 5% total body surface area burn alone or s.c. infection with P. aeruginosa alone. However, when mice were burned then inoculated s.c. with P. aeruginosa at the burn site, all MBL null mice died by 42 h from septicemia, whereas only one-third of wild-type mice succumbed (p = 0.0005). This result indicates that MBL plays a key role in containing and preventing a systemic spread of P. aeruginosa infection following burn injury and suggests that MBL deficiency in humans maybe a premorbid variable in the predisposition to infection in burn victims.

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“…Some trace elements, especially copper, selenium, and zinc, are indeed involved in both humoral and cellular immunity [2,3]. Antibody production, neutrophil function, and natural killer cell activity decrease in trace element deficiency [4].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Hemin and Deferoxamine on Selenium, Zinc, and Iron Levels of K562 Cells

Küçükkaya¹,

Afrasyap²

2011

JCT

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No differences were observed in selenium levels of the control group compared with the hemin-induced group. Also there were no significant differences observed in the zinc levels of control cells compared with deferoxamine-and hemin-induced cells. Iron levels of hemin-induced cells were decreased on the fourth day compared with the third day. On the third day, iron levels of hemin-induced cells were significantly increased compared to the control group. Our observations suggest that alterations of selenium and zinc levels may play a role in hemin-inductionand deferoxamine-inhibition, respectively. On the other hand, iron levels may influence both in hemin-induction and deferoxamine-inhibition of K562 human leukemia cell line.

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Burning the largest immune organ

Cited by 105 publications

References 143 publications

Liposomal IGF-1 gene transfer modulates pro- and anti-inflammatory cytokine mRNA expression in the burn wound

Liposomal IGF-1 gene transfer modulates pro- and anti-inflammatory cytokine mRNA expression in the burn wound

Deficiency of Mannose-Binding Lectin Greatly Increases Susceptibility to Postburn Infection withPseudomonas aeruginosa

The Effect of Hemin and Deferoxamine on Selenium, Zinc, and Iron Levels of K562 Cells

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