Burned-out tumour: A case report

Peroux, É.; Thome, A.; Geffroy, Y.; Guema, B.N.; Arnaud, François-Xavier; Tériitéhau, C.; Baccialone, J.; Potet, Julien

doi:10.1016/j.diii.2012.03.023

Cited by 7 publications

(6 citation statements)

References 7 publications

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“…Tumour markers are fundamental to the diagnostic approach, staging, treatment and follow-up; they show up in varying forms depending on the histological lineage and the response to treatment. In our report, during the initial diagnostic, LDH was increased in all of the cases in relation to the metastasis and tumour burden, in two patients with HCG and in one with AFP [4, 5, 25, 38, 60].…”

Section: Discussionmentioning

confidence: 48%

“…The sensitivity of the testicular ultrasound for diagnosing GCT is close to 100%, so all young patients with a retroperitoneal or mediastinal mass should undergo this test. The characteristics of testicular tumour regression are not specific, as there have been findings of hyperechogenic, hypoechogenic and mixed lesions, nodular and linear areas, signs of testicular atrophy and/or acoustic shadowing reflecting calcifications or fibrosis [3, 26, 59, 60]. If the ultrasound results are inconclusive, scrotal magnetic resonance imaging (sMRI) can be useful in better defining these findings that are not necessarily malignant (infarction, ischemia, trauma or infection) [43, 59, 61].…”

Section: Discussionmentioning

confidence: 99%

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Spontaneous testicular tumor regression: case report and historical review

Astigueta

Abad-Licham

Agreda³

et al. 2018

ecancer

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Spontaneous regression of a primary testicular germ-cell tumour (GCT), over time known as ‘Burned out’, ‘Shrinking Seminoma’, ‘pT0’, ‘Burnout’ or ‘Spontaneous Regression’, is an uncommon, generally metastatic phenomenon, which may present elevated tumour markers and a suspicious testicular ultrasound image. The histological study of the testicle demonstrated morphological changes of complete or partial tumour regression and found fibrous scarring and other characteristic changes of this phenomenon, which in some cases include vestiges of GCT.There are few publications on testicular GCT tumour regression and those that exist present limited data on the biology of the disease and its etiopathogenesis. This entity was recently recognised in the latest edition of the World Health Organization’s (WHO) Classification of Tumours.We present our clinical, imaging, laboratory, cytohistological and management experience, as well as a historical review of the literature.

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Section: Discussionmentioning

confidence: 48%

Section: Discussionmentioning

confidence: 99%

Spontaneous testicular tumor regression: case report and historical review

Astigueta

Abad-Licham

Agreda³

et al. 2018

ecancer

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“…Therefore, supplemental studies with ultrasound are mandatory (7). Ultrasound scan reveals a hyperechogenic, sometimes calcified area, corresponding to the tumoral scar, a hypo or hyperechogenic area that may be observed in contact with the lesion, corresponding to the residual tumor (4).…”

Section: Discussionmentioning

confidence: 99%

“…The metastases of testicular germ cell tumors mainly develop through lymphatic route. Only pure choriocarcinoma is spread through haematogenic pathway (4).…”

Section: Introductionmentioning

confidence: 99%

Burned-out Post Pubertal Teratoma Presenting as a Liver Metastases in a 34-Year-Old Male

2021

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Scan to discover onlineGerm cell teratomas belong to non-seminomatous germ cell tumors and account for 95% of malignant testicular tumors. Regarding the current World Health Organization (WHO) criteria, testicular teratomas are divided into prepubertal and post-pubertal subtypes based on patients' age. The term "burned-out testicular tumor" is a very rare condition referring to a regressed testicular tumor which presents with its metastases without any clinical finding in the testicle. Metastasis can be the presentation of postpubertal teratoma in 22-37% of cases. In scar associated teratoma (burn-out component), the metastasis rate is 66%. We reported a rare case of post-pubertal teratoma in a 34-year-old male who presented with multiple liver masses initially. Liver biopsy revealed poorly differentiated adenocarcinoma probably of gastrointestinal (GI) tract origin. The upper and lower GI endoscopy were normal. Scrotal ultrasonography showed a hypoechoic cystic intratesticular lesion in the left testis. The patient underwent radical orchiectomy and the histopathologic examination revealed postpubertal teratoma with burned out component. The patient underwent proper treatment and is still under follow up. As a result, in a young male patient who presented with a retroperitoneal mass or poorly differentiated carcinomas of an unknown primary site, using light microscopy and immunohistochemical profiling alone may be inadequate. Therefore, scrotal screening and physical examination of the scrotum and bilateral testis should be considered to exclude possibility of a metastatic progression from a testicular germ cell neoplasia.

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“…Burned-out testis tümörlü hastalar kliniğe farklı şekillerde başvurabilir. Retroperitoneal kitleye bağlı bası bulguları ve ağrı yanısıra epididimit ve antibiyoterapi öyküsü söz konusu olabilir (2,16,19). Lenfadenopati ve akciğer problemleri de bildirilmiştir (20).…”

Section: "Burned-out" Germ Hücreli Tümörlerin Klinik öZellikleriunclassified

“Burned-Out” Germ Cell Tumors of the Testis

Özlük

2014

uob

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Testiste "burned-out" tümör kavramı, mevcut germ hücreli tümörün herhangi bir tedavi almadan, spontan total ya da parsiyel regresyonu olarak tanımlanır. Klinikte sıklıkla hastada metastatik bir odağın saptanması ile ortaya çıkar. Testiküler "burned-out" tümör nadir rastlanılan bir antite olup, bu derlemede klinik, radyolojik ve patolojik özelliklerinin vurgulanması amaçlanmıştır. Bu hastalarda en sık metastatik odak retroperitoneal lenf nodudur. Testise yapılan klinik muayenede çoğu zaman palpasyon bulgusu olmayıp, yapılan skrotal ultrasonografik incelemelerde hipoekojen odaklar veya kalsifikasyonlar saptanır. Orşiektomi materyallerinde patolojik değerlendirmede rezidü tümör ve/veya fibröz doku belirlenebilir. Sadece fibröz dokunun bulunduğu durumlarda hematoksifilik cisimcikler, mikrolitler, tubuler atrofi ve intratubuler germ hücre neoplazisi varlığı regrese bir germ hücreli tümör lehine yorumlanmalıdır. Metastaz ile kliniğe yansıyan, testisteki primer tümörün regresyonu ile karakterize "burned-out" germ hücreli tümörler nadir ama akılda tutulması gereken tümörlerdir. Retroperitoneal germ hücreli tümörler aksi ispat edilene kadar testisteki regrese odağın metastazı olarak kabul edilmelidir. Hem tanı hem de tedavi amacı taşıması nedeni ile bu hastalarda orşiektomi mutlaka yapılmalıdır. Orşiektomi materyallerinde makroskopik incelemenin çok sayıda kesit alınarak yapılması küçük odakların dahi saptanabilmesi için oldukça önemlidir. Anah tar Ke li me ler: Burned-out, testis, germ hücreli tümörBurned-out tumors of the testis are defined as spontaneous total or partial regression of a testicular germ cell tumor without any treatment. They usually present at the metastatic stage. Burned-out testicular tumors are rare entities and it was aimed to emphasize their clinical, radiological and pathological features in this review. Retroperitoneal lymph nodes are the most common metastatic sites of these tumors. Physical examination of testicles shows no palpable mass. Scrotal ultrasonography may show hypoechoic lesions and/or calcifications. Orchiectomy materials mostly display residual tumor and/or fibrous scar. Hematoxyphilic bodies, microliths, tubular atrophy and intratubular germ cell neoplasia in a testis having only a fibrous scar indicate regression of primary testicular tumor. Metastatic testicular germ cell tumors showing regression in the primary site, so-called burned-out tumors, should be kept in mind although they are rare. Retroperitoneal germ cell tumors should always be considered as burned-out testicular neoplasm until proven otherwise. Orchiectomy should be certainly performed for both diagnostic and therapeutic purposes. Macroscopic evaluation of orchiectomy materials via having many section samples is important in the detection of small foci of regressed tumors.

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Burned-out tumour: A case report

Cited by 7 publications

References 7 publications

Spontaneous testicular tumor regression: case report and historical review

Spontaneous testicular tumor regression: case report and historical review

Burned-out Post Pubertal Teratoma Presenting as a Liver Metastases in a 34-Year-Old Male

“Burned-Out” Germ Cell Tumors of the Testis

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