Burn Wound Assessment in Porcine Skin Using Indocyanine Green Fluorescence

Jerath, Maya R.; Schomacker, Kevin T.; Sheridan, Robert L.; Nishioka, Norman S.

doi:10.1097/00005373-199906000-00022

Cited by 32 publications

(12 citation statements)

References 14 publications

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“…Some noninvasive techniques analyze the perfusion of the burn wound based on the fact that tissue damage is inversely proportional to the vascularization after the lesion. [40][41][42] Nevertheless, in these procedures it is necessary to supply a vital colorant to the patient by intravenous method and it is essential to have an emergency system. Other experimental techniques analyze the changes in optical properties of the skin related to the changes of its vascularization, 43 although their application environment is, for the moment, exclusively experimental.…”

Section: Discussionmentioning

confidence: 99%

Segmentation and classification of burn images by color and texture information

et al. 2005

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Abstract. In this paper, a burn color image segmentation and classification system is proposed. The aim of the system is to separate burn wounds from healthy skin, and to distinguish among the different types of burns (burn depths). Digital color photographs are used as inputs to the system. The system is based on color and texture information, since these are the characteristics observed by physicians in order to form a diagnosis. A perceptually uniform color space (L*u*v*) was used, since Euclidean distances calculated in this space correspond to perceptual color differences. After the burn is segmented, a set of color and texture features is calculated that serves as the input to a Fuzzy-ARTMAP neural network. The neural network classifies burns into three types of burn depths: superficial dermal, deep dermal, and full thickness. Clinical effectiveness of the method was demonstrated on 62 clinical burn wound images, yielding an average classification success rate of 82%.

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Section: Discussionmentioning

confidence: 99%

Segmentation and classification of burn images by color and texture information

et al. 2005

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“…36 ICG fluoresces in the near-infrared range, which conveniently penetrates deeper into dermal vasculature than other wavelengths of light. 37 The fluorescent light is captured and translated into a perfusion map that demonstrates vascular degeneration in wounded areas, which is a marker to assess the severity of burned tissue. 38 ICG imaging accurately differentiates burn depth, as shown in several studies.…”

Section: Icg Imagingmentioning

confidence: 99%

“…[39][40][41] Because vascular degradation occurs quickly after injury, ICG videoangiography can be used very early following initial burn injury. 37 The major drawback of ICG imaging, however, is its invasiveness. Although the safety of ICG dye has been confirmed over decades of use, rare side effects, including headache, itching, rash, and anaphylactic reactions, have been reported.…”

Section: Icg Imagingmentioning

confidence: 99%

Imaging Techniques for Clinical Burn Assessment with a Focus on Multispectral Imaging

Thatcher

Squiers

Kanick

et al. 2016

Advances in Wound Care

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“…40 A third imaging technology was based on indocyanine green fluorescence. 41 This technique requires the intravenous injection of indocyanine green and a specific imaging device, and did not progress beyond the initial clinical studies.…”

Section: Imaging Of Wounds and Extremitiesmentioning

confidence: 99%

Application of novel hyperspectral imaging technologies in combat casualty care

Cancio

2010

SPIE Proceedings

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Novel hyperspectral imaging (HSI) methods may play several important roles in Combat Casualty Care: (1) HSI of the skin may provide spatial data on hemoglobin saturation of oxygen, as a "window" into perfusion during shock. (2) HSI or similar technology could be incorporated into closed-loop, feedback-controlled resuscitation systems. (3) HSI may provide information about tissue viability and/or wound infection. (4) HSI in the near-infrared range may provide information on the tissue water content--greatly affected, e.g., by fluid resuscitation. Thus, further refinements in the speed and size of HSI systems are sought to make these capabilities available on the battlefield. COMBAT CASUALTY CARE CHALLENGESThe purpose of this paper is to review the uniquely challenging characteristics of combat casualty care, and to provide an assessment of several ways in which hyperspectral imaging (HSI) could contribute to improving diagnostic and treatment capabilities in this setting. Several papers on HSI in trauma and related applications will be reviewed.Interest in HSI is not limited to its potential application on the battlefield. However, combat casualty care is a stringent test of the utility of any new medical technology. Battlefield care represents a point of departure from civilian trauma care in several important respects. These include differences in the mechanism and severity of injury; in the materiel and personnel available for care; and in the environmental circumstances under which care is provided.The leading cause of injury on the current battlefield is the improvised explosive device (IED), 1 whereas the leading cause of injury in civilian trauma systems in the U.S. is blunt trauma from falls and motor vehicle accidents. 2 The severity of injury on the current battlefield is indicated by a high percentage of patients with Injury Severity Scores (ISS) over 15 and a high massive transfusion rate (defined as > 10 units of red blood cells or whole blood over the first 24 h after injury). In one study of combat casualties treated at a single Combat Support Hospital in Iraq, of 302 patients who received any blood during the first 24 h, 80 patients (27%) received a massive transfusion. 3 The leading cause of death on the battlefield remains hemorrhagic shock, followed by neurological trauma (severe head injury). 4Our ability to provide care on the battlefield is greatly affected by constraints in the weight and cube of devices and drugs which can be utilized in the prehospital setting. In other words, combat medics are severely limited in what they can carry to the casualty at the point of injury. In essence, a decision to add a device or drug to the medic's aid bag must be accompanied by a decision to remove something from the bag: there is no room for additional items. As patients move up the evacuation chain, more equipment becomes available. The mature Combat Support Hospital, for example, routinely utilizes computed tomography (CT) scanners for the diagnosis of injury. 5 There are constraints in the training ...

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Burn Wound Assessment in Porcine Skin Using Indocyanine Green Fluorescence

Abstract: Deep partial-thickness burns were differentiated from deep dermal full-thickness burns in a porcine skin burn model independent of body location. Diagnosis was possible between 1 and 72 hours after injury.

Cited by 32 publications

References 14 publications

Segmentation and classification of burn images by color and texture information

Segmentation and classification of burn images by color and texture information

Imaging Techniques for Clinical Burn Assessment with a Focus on Multispectral Imaging

Application of novel hyperspectral imaging technologies in combat casualty care

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