Burn Toxin in Mouse Skin

Allgöwer, M.; Lb, Cueni; Städtler, K; Ga, Stalder

doi:10.1097/00005373-197302000-00002

Cited by 32 publications

(3 citation statements)

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“…Several investigators have reported the presence of toxic substances in skin and blood serum of burned experimental animals or of human patients, e.g. Allgower et al, 1973, Rosenthal et al, 1972. In a previous report (Moati et al, 1977) we have described the presence of cardiotoxic and neurotoxic factors in Cohn fractions obtained from the sera of burned patients.…”

mentioning

confidence: 82%

Biochemical and pharmacological properties of a neurotoxic protein isolated from the blood serum of heavily burned patients

Sepulchre¹,

Moati²,

Miskulin³

et al. 1979

The Journal of Pathology

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Blood serum of heavily burned patients contains neurotoxic substances which are not present in normal control sera. In the present paper, we describe the purification by gel filtration and ultracentrifugation of such a neurotoxic factor. The purified factor appeared to be a high molecular weight (2 to 3.10(6) daltons) lipoprotein. This factor was present in all the sera of patients with more than 35 per cent of the body surface burned. When injected into rabbits the lipoprotein caused a flattening of the EEG tracing, then trembling and convulsions with bursts of spikes on the EEG. The activity of this neurotoxic substance was enhanced when the permeability of the blood-brain barrier was increased by previous intraventricular injection of collagenase. The presence of such a neurotoxic factor in the blood serum of burned patients, together with the increased serum collagenase activity they exhibit may explain the neurotoxic symptoms observed in them.

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mentioning

confidence: 82%

Biochemical and pharmacological properties of a neurotoxic protein isolated from the blood serum of heavily burned patients

Sepulchre¹,

Moati²,

Miskulin³

et al. 1979

The Journal of Pathology

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“…The necrotic or denatured skin of burn wounds is typically discarded during treatment due to the formation of cutaneous burn toxins ( 13 ). Burn toxins, which include free radicals, lipoproteins, lipopolysaccharides and lipid peroxides, are formed as a result of thermal injury to skin and are released into the interstitial fluid and serum during the early stages of burns ( 14 – 17 ). These hazardous substances have been shown to exert various effects, including immunosuppression, mitochondrial destruction, cellular energy metabolic disorders and increasing the permeability of the cell membrane, which in turn have been implicated in the various complications associated with burns, including sepsis and multiple organ dysfunction syndrome ( 16 , 18 – 25 ).…”

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confidence: 99%

A novel dermal matrix generated from burned skin as a promising substitute for deep-degree burns therapy

Tan

Zhu

et al. 2016

Molecular Medicine Reports

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The extensive skin defects induced by severe burns are dangerous and can be fatal. Currently, the most common therapy is tangential excision to remove the necrotic or denatured areas of skin, followed by skin grafting. Xenogeneic dermal substitutes, such as porcine acellular dermal matrix (ADM), are typically used to cover the burn wounds, and may accelerate wound healing. It is assumed that burned skin that still maintains partial biological activity may be recycled to construct an autologous acellular dermal matrix, termed 'deep-degree burned dermal matrix (DDBDM)'. In theory, DDBDM may avoid the histoincompatibility issues associated with foreign or xenogeneic dermal matrices, and reduce therapy costs by making full use of discarded skin. In the present study, the collagens within prepared DDBDM were thickened, disorganized and partially fractured, however, they still maintained their reticular structure and tensile strength (P<0.01). Through microarray analysis of the cytokines present in ADM and DDBDM, it was determined that the DDBDM did not produce excessive levels of harmful burn toxins. Following 4 weeks of subcutaneous implantation, ADM and DDBDM were incompletely degraded and maintained good integrity. No significant inflammatory reaction or rejection were observed, which indicated that ADM and DDBDM have good histocompatibility. Therefore, DDBDM may be a useful material for the treatment of deep-degree burns.

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“…The substances could be formed in the skin after the burn, transferred into the general circulation and cause damages in other tissues. Several researchers have separated the "toxic substances" of various nature and degree of purity from human or animal skin, or sera, after the burn, and have assessed the toxic activity by various methods [1][2][3][4][5].…”

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confidence: 99%

A Novel Uncoupler of Mitochondrial Respiration, 9, 10-Epoxy-12-octadecenoate, Exists in Human Burned Skin

Yokoo

Hayakawa

Sugiyama

et al. 1986

J. Clin. Biochem. Nutr.

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SummaryIn human burned skin, several polyunsaturated fatty acids, especially linoleate and its peroxide were isolated by high-performance liquid chromatography. Chemical structure of the epoxide was determined to be 9,10-epoxy-12-octadecenoate by gas-chromatography/mass spectrometry, nuclear magnetic resonance measurements and ozonolysis. The epoxide showed an uncoupling activity to liver mitochondria) respiration and diminished the respiratory control of mitochondria. Formation of the epoxide in the burned skin was related to clinical observation of the "burn toxin" which appears after severe burns.

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Burn Toxin in Mouse Skin

Cited by 32 publications

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Biochemical and pharmacological properties of a neurotoxic protein isolated from the blood serum of heavily burned patients

Biochemical and pharmacological properties of a neurotoxic protein isolated from the blood serum of heavily burned patients

A novel dermal matrix generated from burned skin as a promising substitute for deep-degree burns therapy

A Novel Uncoupler of Mitochondrial Respiration, 9, 10-Epoxy-12-octadecenoate, Exists in Human Burned Skin

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