Burn scar regeneration with the “SUFA” (Subcision and Fat Grafting) technique. A prospective clinical study

Gargano, Francesco; Schmidt, Scott; Evangelista, Peter; Robinson‐Bostom, Leslie; Harrington, David; Rossi, Kristie; Guo, Yfan; Liu, Paul

doi:10.1016/j.jpra.2018.05.001

Cited by 5 publications

(6 citation statements)

References 6 publications

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“…Fat grafting has previously shown efficacy for burn scars [41,42], fibrosis [43,44], pain [45] and radiation damage [46][47][48], and the authors of this study have previously seen good efficacy in the use of PHAT for these reconstructive interventions. Recently, fat grafting has been demonstrated to improve the quality of hair and studies have focused on the stromal vascular fraction and autologous fat transfer [49][50][51][52].…”

Section: Introductionmentioning

confidence: 66%

“…Follicle activation [39] FGF Hair follicle precursor formation [40] induction and maintenance of anagen from telogen phase through beta-catenin [41] synergistic cell proliferation with PDGF [42] VEGF Dermal papilla cells secrete to promote angiogenesis and vessel permeability [38]. Control of follicle size during the anagen phase [43,44] Blocks androgenic alopecia through Pi3-k/Akt in humans [45] Promotes growth of vessels [46] PDGF Epithelial development into dermal papillae [36] increases proliferation and is present throughout the cycle [42,[47][48][49] IGF-1 Cell proliferation and migration regulator prevents catagen [50,51] EGF Proliferation of outer root sheath hair cells in anagen [52][53][54] around the head with no tension for 48 hours, and the patient is asked to sleep slightly elevated to avoid fluid migration and facial edema. The patients are also given 500mg Tylenol PO at the end of procedure and the next morning.…”

Section: All Steps Should Be Performed Expeditiously As Possible To Obtain Greater Efficacy From Fresh Prp and Nanofatmentioning

confidence: 99%

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Platelet Rich Plasma Hybridized Adipose Transplant (PHAT) for the Treatment of Hair Loss: A Case Series

2021

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Background Platelet-rich plasma (PRP) has long been used for the restoration of hair in conjunction with microneedling or on its own. Fat grafting to the scalp has also been utilized in the past to improve the quality of hair and the possibility of successful hair transplant. The novel therapy reported in this case series combines the natural progression of these two techniques and utilizes synergistic effects to improve the quality of hair, either in preparation for micrografting or without hair transplant. Objectives To demonstrate the principles behind the novel approach to restoration of hair and the rationale for its use. Methods A review of the evidence for PRP and fat transfer for non-scarring alopecia serves as the foundation for the combination treatment reported herein. Through presentation of three cases in this series, we provide examples of the utility of this approach for non-scarring alopecia. This report includes a female who suffered non-scarring alopecia following COVID-19 hospitalization and intensive care stay where she lost a large percentage of her hair, in addition to two male patients suffering from androgenic alopecia. Results Platelet-rich plasma-hybridized adipose transplant hair was shown in these three cases to improve both the quality and density of hair. It improved the density of hair in all patients and was characterized first by a short period of transient hair loss followed by new hair growth which develops starting at 4 weeks and was readily apparent at 12-week follow-up. Results were maintained at 6-month and 1-year follow-up. Conclusions PHAT hair offers a combination of beneficial effects-namely the unique healing properties and growth signaling provided by PRP, along with adipocyte angiogenic and growth signaling, which both work to improve scalp quality. The combination of these effects is better than previously characterized PRP injections alone in the hands of these individual practices. This may be due to synergistic interactions at a cellular level, but additional clinical studies are needed to better understand this novel treatment and the observed effects.

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Section: Introductionmentioning

confidence: 66%

Section: All Steps Should Be Performed Expeditiously As Possible To Obtain Greater Efficacy From Fresh Prp and Nanofatmentioning

confidence: 99%

Platelet Rich Plasma Hybridized Adipose Transplant (PHAT) for the Treatment of Hair Loss: A Case Series

2021

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“…The Meek micrograph technique was developed to gain the most coverage from a small amount of available skin, using small full-thickness skin grafts, and demonstrated promising results in terms of contracture rate. 88,89 Fat grafting was utilized to restore volume and counteract skin tethering as well as for its therapeutic effects 35,90–96…”

Section: Resultsmentioning

confidence: 99%

Prevention and Treatment of Burn Scar Contracture: A Practical Review

Raborn,

Janis

2024

Plastic and Reconstructive Surgery - Global Open

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Summary: Burn contracture affects close to one-third of all burn patients, leading to significant functional impairment and costs. Effective prevention and treatment strategies are necessary to decrease morbidity and unnecessary costs. This scoping review aimed to summarize prevention and treatment strategies used for management of burn scar contractures published in the literature since 2000. A comprehensive PubMed review was performed in October 2022 to identify methods of burn contracture prevention and treatments. Non-English, duplicate, and unavailable articles were excluded. Data were extracted including publication year, techniques, and outcomes. A total of 327 publications met criteria for inclusion. Most articles were published in 2011 (n = 22). Treatment strategies were discussed in 82.9% of studies, prevention in 16.5%, and both in 0.6%. The most common areas discussed included the upper extremity (n = 127) and neck (n = 102). Flaps were the most frequently used method (n = 208), followed by autografts (n = 89). Most preventative therapies were still in early stages of development. Burn contracture management requires a highly individualized approach with many available reconstructive techniques available. Further research is needed to improve prevention techniques and decrease morbidity and cost to patients.

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“…Additionally, there is literature suggesting the regenerative capacity of adipose-derived stem cells in scar treatment. [28][29][30][31] In our experience, we regularly perform PHAT in our surgical patients undergoing lip-lifting, and/or facelifting. There may be some ancillary benefit of PHAT treatment on the surgical incision sites, with potential reductions in postoperative infection, pain, and blood loss.…”

Section: Other Adjunctive Proceduresmentioning

confidence: 99%

“…The general theory is that using the PHAT in combination with our routine procedures may exploit the regenerative pathways discussed below. Additionally, there is literature suggesting the regenerative capacity of adipose derived stem cells in scar treatment [29][30][31][32] . In our experience, we regularly perform PHAT in our surgical patients undergoing liplifting, and or/ facelifting.…”

Section: Other Adjunctive Proceduresmentioning

confidence: 99%

PHAT Lips and PHAT Face: Platelet Hybridized Adipose Therapy for Superficial Musculoaponeurotic System and Dermal Rejuvenation

Talei,

Ziai

2023

Facial Plast Surg

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Platelet-rich plasma (PRP) has increasingly been used for facial rejuvenation in conjunction with other modalities such as microneedling or on its own. Nanofat grafting to the face has also been utilized for skin quality improvements. Our group previously described the novel combined PHAT (Platelet Hybridized Adipose Transplant)1 technique for hair restoration. In this series, we describe our experience with PHAT technique for lip and facial rejuvenation to improve the quality of facial skin and superficial musculoaponeurotic system (SMAS), and enhancing surgical results.

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Burn scar regeneration with the “SUFA” (Subcision and Fat Grafting) technique. A prospective clinical study

Cited by 5 publications

References 6 publications

Platelet Rich Plasma Hybridized Adipose Transplant (PHAT) for the Treatment of Hair Loss: A Case Series

Platelet Rich Plasma Hybridized Adipose Transplant (PHAT) for the Treatment of Hair Loss: A Case Series

Prevention and Treatment of Burn Scar Contracture: A Practical Review

PHAT Lips and PHAT Face: Platelet Hybridized Adipose Therapy for Superficial Musculoaponeurotic System and Dermal Rejuvenation

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