Burn Scar Biomechanics after Pressure Garment Therapy

Kim, Jayne Y.; Willard, James M.; Supp, Dorothy M.; Roy, Sashwati; Gordillo, Gayle M.; Sen, Chandan K.; Powell, Heather M.

doi:10.1097/prs.0000000000001507

Cited by 42 publications

(31 citation statements)

References 32 publications

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“…The female (or castrated male) red Duroc pig develops hypertrophic scar following excisional or burn wounding. 69–74 This model is used to study the ontogeny of hypertrophic scar and intervention efficacy. 74 Another exciting development has been the grafting of human scar tissue onto the backs of immune-compromised mice; this model has facilitated studies of the scarring process itself, including the role of immune cells in hypertrophic scar by utilizing animals with various immune cells knocked out.…”

Section: Models For Studying Post-burn Scarmentioning

confidence: 99%

“…69–74 This model is used to study the ontogeny of hypertrophic scar and intervention efficacy. 74 Another exciting development has been the grafting of human scar tissue onto the backs of immune-compromised mice; this model has facilitated studies of the scarring process itself, including the role of immune cells in hypertrophic scar by utilizing animals with various immune cells knocked out. 75,76 With these models becoming more widely available, it will be possible to conduct tightly controlled studies to evaluate therapy efficacy and to perform mechanistic studies.…”

Section: Models For Studying Post-burn Scarmentioning

confidence: 99%

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Hypertrophic scarring: the greatest unmet challenge after burn injury

et al. 2016

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Summary Improvements in acute burn care have enabled patients to survive massive burns which would have once been fatal. Now up to 70% of patients develop hypertrophic scars following burns. The functional and psychosocial sequelae remain a major rehabilitative challenge, decreasing quality of life and delaying reintegration into society. The current approach is to optimise the healing potential of the burn wound using targeted wound care and surgery in order to minimise the development of hypertrophic scarring. This approach often fails, and modulation of established scar is continued although the optimal indication, timing, and combination of therapies have yet to be established. The need for novel treatments is paramount, and future efforts to improve outcomes and quality of life should include optimisation of wound healing to attenuate or prevent hypertrophic scarring, well-designed trials to confirm treatment efficacy, and further elucidation of molecular mechanisms to allow development of new preventative and therapeutic strategies.

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Section: Models For Studying Post-burn Scarmentioning

confidence: 99%

Section: Models For Studying Post-burn Scarmentioning

confidence: 99%

Hypertrophic scarring: the greatest unmet challenge after burn injury

et al. 2016

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“…There are many methods for the treatment of the Hyperplasia scar, such as pressure therapy, intralesional corticosteroids, radiation therapy and topical medications [3]. Pressure therapy is one of the most effective methods to prevention and treatment of Hyperplasia scar and this method is easy to operate, having an exact curative effect, low price, and is noninvasive treatment [4,5].…”

Section: Introductionmentioning

confidence: 99%

Compression Sleeves Design Based on Laplace Laws

Zhao¹,

Li²,

Yu³

et al. 2017

JTEFT

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Compression sleeves are very important to the prevention and control of human limb hyperplasia scaring. The garment pressure is the key determinant of the curative effect, and one of the key factors which influence this value is the precision of Compression sleeves design. In order to study the design and performance of Compression sleeves via relatively simple but accurate methodologies, different deformation formulas of Laplace law were summarized and analyzed. Firstly, it was found that both of the deformation formulas of Laplace law proposed by Maklewska and Leung respectively were based on the principle that the arm radius was calculated by the arm circumference, furthermore, the arm radius, fabric tensile index and the preset clothing pressure were substituted into the Laplace law formula, and the sizes of the Compression sleeves could be calculated. Since the design methods proposed above were easier to implement in practical production, Compression sleeves were designed and manufactured based on the deformation formulas of Laplace law, and garment pressures were tested and compared with the preset pressures. Experimental results showed that garment pressures of the Compression sleeves which were designed based on the Maklewska Laplace law within the scope of the required pressure value, so this deformation could be used for designing the Compression sleeves accurately. However, the sizes of the Compression sleeves which were calculated based on the Leung Laplace law were too small to put on, so the formula of Leung Laplace law was not suitable for designing the Compression sleeves.

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“…Although it represents the standard care for prevention and treatment of HS from burns, there is no scientific evidence for its uses and its practice is largely based on empirical evidence14. Firstly, the exact optimal pressure required for effective treatment has never been scientifically established151617.…”

mentioning

confidence: 99%

The effectiveness of pressure therapy (15–25 mmHg) for hypertrophic burn scars: A systematic review and meta-analysis

Liu

Pei

et al. 2017

Sci Rep

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Although pressure therapy (PT) represents the standard care for prevention and treatment of hypertrophic scar (HS) from burns, its practice is largely based on empirical evidence and its effectiveness remains controversial. To clarify the effect of PT (15–25 mmHg) for HS, we performed the systematic review and meta-analysis. Several electronic databases were screened to identify related randomized controlled trials (RCTs). 12 RCTs involving 710 patients with 761 HS resulting from burn injuries were included. Compared with non/low-PT, cases treated with PT (15–25 mmHg) showed significant differences in Vancouver Scar Scale score (MD = −0.58, 95% CI = −0.78–−0.37), thickness (SMD = −0.25, 95% CI = −0.40–−0.11), brightness (MD = 2.00, 95% CI = 0.59–3.42), redness (MD = −0.79, 95% CI = −1.52–−0.07), pigmentation (MD = −0.16, 95% CI = −0.32–−0.00) and hardness (SMD = −0.65, 95% CI = −1.07–−0.23). However, there was no difference in vascularity (MD = 0.03, 95% CI = −0.43–0.48). Our analysis indicated that patients with HS who were managed with PT (15–25 mmHg) showed significant improvements. Due to limitations, more large and well-designed studies are needed to confirm our findings and the side-effects of the PT may also need to be evaluated.

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Burn Scar Biomechanics after Pressure Garment Therapy

Cited by 42 publications

References 32 publications

Hypertrophic scarring: the greatest unmet challenge after burn injury

Hypertrophic scarring: the greatest unmet challenge after burn injury

Compression Sleeves Design Based on Laplace Laws

The effectiveness of pressure therapy (15–25 mmHg) for hypertrophic burn scars: A systematic review and meta-analysis

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