Burn Depth Estimation By Use of Indocyanine Green Fluorescence: Initial Human Trial

Sheridan, R.; Schomaker, K. T.; Lucchina, Leslie C.; Hurley, John A.; Yin, Lin; Tompkins, Ronald G.; Jerath, Maya R.; Torri, Andrea; Greaves, Kim; Bua, D.; Nishioka, Norman S.

doi:10.1097/00004630-199511000-00007

Cited by 80 publications

(39 citation statements)

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“…coagulated dermal vessels) with function (i.e. impaired local perfusion) [41]. However, Haslik et al [42] showed that commonly used ointments and dressings had a 'massive influence' on ICG video angiography causing decreases in absorption of up to 63% leading to a dramatic overestimation of the depth of the burn wounds.…”

Section: Vital Dyesmentioning

confidence: 99%

Assessment of burn depth and burn wound healing potential

Monstrey

Hoeksema

Verbelen

et al. 2008

Burns

370

266

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Section: Vital Dyesmentioning

confidence: 99%

Assessment of burn depth and burn wound healing potential

Monstrey

Hoeksema

Verbelen

et al. 2008

Burns

370

266

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“…Furthermore, IcG has already been detected through skin (15,16). IcG is approved for use in humans for monitoring of burn severity (17,18), ophthalmology, liver and kidney function, and to measure blood volume (19 -23). Hence, at least one potential fluorophore is available.…”

Section: Discussionmentioning

confidence: 99%

Polarization Sensing of Fluorophores in Tissues for Drug Compliance Monitoring

Gryczyński

Abugo

Lakowicz

1999

Analytical Biochemistry

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We used a new method, polarization sensing, to monitor the concentration of the fluorophore rhodamine 800 in an intralipid suspension and in chicken tissue. Rhodamine 800 (Rh800) could be excited at 648 nm using a laser pointer. We developed a simple device for measuring the combined emission from a highly polarized reference film and the unpolarized or orthogonally polarized emission of Rh800 from the scattering intralipid or tissue. The concentration of Rh800 in this medium was revealed by large changes in the polarization (P) with values of P ranging from 0.8 to -0.9. It is possible to vary the sensitive Rh800 concentration range by variation of the detected emission wavelengths, orientation of the excitation polarizer, or fluorophore concentration in the reference film. Polarization sensing of fluorophores in tissue requires only steady-state detection, and can be accomplished with simple and/or portable electronics. Such devices may find use in electronic detection of ingested medicines based on transdermal detection of nontoxic long-wavelength fluorophores.

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“…13,14 To our knowledge, the use of indocyanine green 2 (ICG)-fluorescence for monitoring of free microvascular flaps has not been reported in the literature.…”

Section: à11mentioning

confidence: 99%

Monitoring free flaps using laser‐induced fluorescence of indocyanine green: A preliminary experience

et al. 2002

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In a prospective, clinical study, the clinical utility of indocyanine green for intraoperative monitoring of free tissue transfer was evaluated. The study comprised 20 surgical patients undergoing elective microsurgical procedures. Indocyanine green angiography was performed intraoperatively, immediately after flap inset, and the operating team was blind to the fluoremetric findings. Thereafter, postoperative monitoring was done exclusively by clinical examination (color, temperature, time for recapillarization, and bleeding after puncture). Final outcome was compared with results of perioperative indocyanine (ICG)-imaging, and classified either as total flap loss, partial flap loss, or successful tissue transplantation. A total of 2 (10%) complications was recorded, and included one partial and one total flap loss. Both complications were detected by intraoperative ICG imaging. Another case of intraoperative subclinical arterial spasm at the place of microvascular anastomosis was revealed by dynamic ICG-videography. This flap did not develop postoperative complications. In conclusion, evaluation of perfusion by ICG imaging is feasible in all kinds of microsurgical flaps, irrespective of the type of tissue. Even though not meeting all the criteria of an ideal monitoring device, significant additional information can be obtained. In this study, cases with arterial spasm, venous congestion, and regional hypoperfusion were revealed by intraoperative ICG-videography. There was a strong correlation between intraoperative findings and clinical outcome.

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Burn Depth Estimation By Use of Indocyanine Green Fluorescence: Initial Human Trial

Cited by 80 publications

References 0 publications

Assessment of burn depth and burn wound healing potential

Assessment of burn depth and burn wound healing potential

Polarization Sensing of Fluorophores in Tissues for Drug Compliance Monitoring

Monitoring free flaps using laser‐induced fluorescence of indocyanine green: A preliminary experience

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