Burkitt's lymphoma presenting as Tolosa-Hunt syndrome

Pina, C. Sánchez; Pascual-Castroviejo, I; Fernández, V. Martínez de Vega; Jiménez, A.L. Martínez; Sanz, Angel Carrasco

doi:10.1016/0887-8994(93)90056-i

Cited by 21 publications

(10 citation statements)

References 8 publications

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“…Alternatively, there is a single report of a patient who presented with symptoms of the Tolosa-Hunt syndrome and who subsequently received a diagnosis of Burkitt's lymphoma. 33 I believe that the current patient had a lymphoblastic lymphoma that was masked as the Tolosa-Hunt syndrome. Because of the bony destruction, Langerhans'-cell histiocytosis would be next on my list of possible diagnoses, followed by orbital pseudotumor and sarcoidosis.…”

Section: Response To Corticosteroids As a Cluementioning

confidence: 84%

“…A few patients with Hodgkin's disease, Burkitt's lymphoma, and other non-Hodgkin's lymphomas have presented with the Tolosa-Hunt syndrome. 32,33 In addition, I must mention the rare, occasionally lethal "midline granuloma syndrome." This disease, which is not necessarily midline, 34 is characterized by progressive, unrelenting ulceration and necrosis, with destruction of the nasal septum.…”

Section: Lymphomamentioning

confidence: 99%

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Case 5-2002

Hurwitz

Faquin

2002

N Engl J Med

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Section: Response To Corticosteroids As a Cluementioning

confidence: 84%

Section: Lymphomamentioning

confidence: 99%

Case 5-2002

Hurwitz

Faquin

2002

N Engl J Med

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“…Suprasellar and parasellar tumors that simulate Tolosa-Hunt Syndrome have also been described. An expansive epidural mass with compression on the vertebral canal is the most common presentation of spinal canal involvement [18,19]. …”

Section: Discussionmentioning

confidence: 99%

Burkitt Lymphoma with Initial Clinical Presentation due to Infiltration of the Central Nervous System and Eye Orbits

et al. 2014

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Patient: Male, 17Final Diagnosis: Burkitt lymphomaSymptoms: Anisocoria, ipsilateral ptosis, opthalmoparesis, paresisMedication: —Clinical Procedure: —Specialty: OncologyObjective:Unusual clinical courseBackground:Burkitt lymphoma rarely affects the central nervous system and ocular region. Under these conditions, computed tomography and (particularly) magnetic resonance imaging of the skull increase the diagnostic accuracy, as they objectively show the topography of lesions and the effect of neoplasia on structures.Case Report:We report here the case of a 17-year-old male whose initial clinical manifestations were related to neurological impairment and to the ocular musculature and ocular innervation. The diagnosis of Burkitt lymphoma with leukemization and infiltration of the central nervous system was confirmed.Conclusions:In this case, it is important to recognize that the neuroimaging findings were fundamentally important in indicating the initial form of the disease and in directing the appropriate clinical management.

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“…Only publications reporting cases of patients 16 years of age or younger at the time of presentation, written in English, and offering sufficient information about clinical course, outcome, and follow-up findings were included. [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] In the children treated by the authors, MRI was performed using the following protocol: T2-weighted sequences in axial, sagittal, and coronal directions, 3 mm slice thickness. Fluidattenuated inversion recovery (FLAIR) was used in all children older than 2 years.…”

Section: Methodsmentioning

confidence: 99%

“…Painful ophthalmoplegia due to a proven CS syndrome is very rare in childhood, and management guidelines are therefore not available. In this study we describe the clinical course in 4 of our own pediatric patients with ophthalmoplegia due to CS lesion and analyze 17 additional patients reported in the literature [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] to gain insight into the spectrum of this entity. To the best of our knowledge, this is the largest overview on CS lesions in children so far.…”

Section: Introductionmentioning

confidence: 99%

Prediction of the Clinical Outcome of Cavernous Sinus Lesions in Children

et al. 2013

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To identify predictive findings in children with nontraumatic acquired cavernous sinus lesions, a retrospective study of the clinical course of 4 of our own patients and 17 more children found in an extensive literature search was performed. Mean age was 8.7 years. Malignancy was found in 11 of 21 children (6 female, 15 male). Of these 21 children, 9 were cured, 8 are either in remission or their course is unknown, and 4 died. Eight of the nine cured patients were diagnosed as having had Tolosa-Hunt syndrome. Of the four deceased children, three had a very short course (1 to 4 months) and were diagnosed with malignant lymphoma (n = 2) and rhabdomyosarcoma (n = 1). One patient died from a brain tumor other than the initially diagnosed T-cell lymphoma in the cavernous sinus after a follow-up of 8 years. MRI should be the preferred imaging technique-even if it is not conclusive in many cases-and every possible diagnostic effort should be made before using corticosteroids. No clinical or radiological signs other than rapid deterioration seem to be predictable of a malignant cavernous sinus lesion with poor outcome. Thus, close follow-up is recommended in children with signs and symptoms indicative of an acquired lesion in the cavernous sinus.

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Burkitt's lymphoma presenting as Tolosa-Hunt syndrome

Cited by 21 publications

References 8 publications

Case 5-2002

Case 5-2002

Burkitt Lymphoma with Initial Clinical Presentation due to Infiltration of the Central Nervous System and Eye Orbits

Prediction of the Clinical Outcome of Cavernous Sinus Lesions in Children

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