Burkitt's leukemia: A re-evaluation

Minerbrook, Mark; Schulman, Philip; Budman, Daniel R.; Teichberg, Saul; Vinciguerra, Vincent; Kardon, Nataline; Degnan, Thomas J.

doi:10.1002/1097-0142(19820401)49:7<1444::aid-cncr2820490722>3.0.co;2-c

Cited by 15 publications

(1 citation statement)

References 28 publications

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“…Almost all varieties are without peripheral lymphadenopathy, but if lymph node involvement is presents then limited to single group of nodes and this is very rare (57,58). Bone marrow involvement is very common in late stage of the disease as described in the staging of the disease but leukemic manifestation is very rare (59,46).Tumor is characterized my monomorphic ,medium size cell with diffuse pattern ,but in early stage shows preferential involvement of the germinal center (60).…”

Section: Pathological Featuresmentioning

confidence: 99%

The Jaw Tumor: A Surgical and Oncologic perspective

Badruddoja

2015

J bio-sci.

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The Jaw tumor is now a very well-known entity in the field of medicine and Called Burkitt Lymphoma Syndrome or Burkitts lymphoma (BL). It is a highly aggressive non-Hodgkins lymphoma and is the fastest growing tumors in children especially in East Africa. This is the first malignant extra nodal lymphoma in which Epstein-Barr virus has been detected specially in the tumors of East African origin. The discovery of EBV is the Burk kits tumor is another progress that has been MADE THE MEDICAL COMMUNITY to understand the disease process. EBV virus may be playing a role as an oncogene for this disease by retranslocating or translocation the c-MYC gene. Early days when such tumor is introduced by Dennis Burkitt before the medical community there was no real pathological classification, immumohistochemical or biological study. Subsequently it was felt that a chromosal translocation that activates an oncogene called e-MYC is the etiology of such tumor. But current molecular study shows that there are other oncogenes that are involved in the development of this deadly ailment especially in western countries. Our knowledge of BL was inadequate in early years of discovery of BL and so as well our diagnosis and treatment. In early stage of discovery of BL there were very limited option of treatment from local radical surgery, local radiation( which was not available in Uganda during that time) to only two chemotherapies and 5 years of survival rate was only 10%.But with our current knowledge of molecular biology of this malignancy there are multiple options of treatment such as combination of various chemotherapies, monoclonal antibodies either alone and or in combination and with either complete removal of tumor or debunking procedure specially abdominal neoplasm, the current 5 years survival rate is about 90%.This very brief review article describes the background, clinical feature, histology ,molecular study as it relates to prognosis and current treatment of both Burkitts tumor and extra nodal abdominal tumor both based on experience of our group in late seventies of treating few cases of devastating abdominal BL and review of few scholarly article on BL. DOI: http://dx.doi.org/10.3329/jbs.v21i0.22513 J. bio-sci. 21: 01-19, 2013

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Section: Pathological Featuresmentioning

confidence: 99%

The Jaw Tumor: A Surgical and Oncologic perspective

Badruddoja

2015

J bio-sci.

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High-degree abnormalities of nuclear DNA distribution in SIg negative acute lymphoblastic leukemia with vacuolated blasts

Riccardi

Montecucco

Girino

et al. 1986

Cancer

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Among 65 consecutive patients with untreated adult acute lymphoblastic leukemia (ALL), six had peculiar clinical and cytologic features. Bone marrow and circulating blasts were large and showed prominent vacuolization, with variable degree of granular periodic acid-Schiff positivity in the cytoplasm. All patients had marked spleen and liver enlargement with cholestasis and without either lymph node or central nervous system disease. They achieved complete response to chemotherapy, and their median survival was longer than 12 months. Blast cells were studied for immunologic markers, propidium iodide flow cytofluorometric DNA content, and in vitro tritiated thymidine labeling index (3H-TdR LI). These showed a "null" phenotype in two cases, contained intracytoplasmic immunoglobulins (Cy mu) in two and were positive for CALL and Ia antigens in two others (one of which also contained Cy mu). Surface immunoglobulins (SIg) were found on less than 12% of cells, and T-cell markers were absent. In five cases, one or two stem lines with highly abnormal modal DNA content were found to coexist with diploid blasts. The 3H-TdR LI was high (8.5%-15.5%). Abnormal cell lines, after being cleared by chemotherapy, were found again at relapse. Additional cell lines appeared during the course of the disease in one patient, having different sensitivity to cytostatics. These cases of ALL apparently derive from B-cells not yet expressing SIg and have an exceptionally high incidence of aneuploid cell lines.

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Hybrid acute leukemia in an HIV‐antibody‐positive patient

et al. 1989

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Although the great majority of acute leukemias have been designated as being of lymphocytic or myelocytic origin, recent reports have described elements of both in some patients. We describe here the first case of hybrid acute leukemia in an HIV-antibody-positive patient as well as the first hybrid involving B-cell (Burkitt) acute lymphocytic leukemia and acute myelomonocytic leukemia proven by cytochemical, immunologic, and cytogenetic methods. This case illustrates the increasingly complex difficulties in the diagnosis and treatment of AIDS-related malignancies.

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Burkitt's leukemia: A re-evaluation

Cited by 15 publications

References 28 publications

The Jaw Tumor: A Surgical and Oncologic perspective

The Jaw Tumor: A Surgical and Oncologic perspective

High-degree abnormalities of nuclear DNA distribution in SIg negative acute lymphoblastic leukemia with vacuolated blasts

Hybrid acute leukemia in an HIV‐antibody‐positive patient

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