Burkitt lymphoma beyond MYC translocation: N-MYC and DNA methyltransferases dysregulation

Falco, Giulia De; Ambrosio, Maria Raffaella; Fuligni, Fabio; Onnis, Anna; Bellan, Cristiana; Rocca, Bruno Jim; Navari, Mohsen; Etebari, Maryam; Mundo, Lucia; Gazaneo, Sara; Facchetti, Fabio; Pileri, Stefano; Leoncini, Lorenzo; Piccaluga, Pier Paolo

doi:10.1186/s12885-015-1661-7

Cited by 26 publications

(24 citation statements)

References 53 publications

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“…These cases were negative for MYC translocation by FISH analysis, using both split and fusion probes for t(8;14), as well as IgH and IgL split probes. It was demonstrated that alternative mechanisms may be responsible of MYC over-expression in the absence of a detectable translocation; among these, microRNAs (miRNAs) deregulation, epigenetic mechanisms and NMYC over-expression [ 52 ]. A gene expression analysis of BL subtypes by Piccaluga et al (2011) [ 53 ] has shown that endemic BL (eBL) have a GEP and a miRNAs expression profile unique and different from those of sporadic BL.…”

Section: Results and Discussion – By Type Of Cancermentioning

confidence: 99%

Cancer of childhood in sub-Saharan Africa

Stefan¹,

Bray²,

Ferlay³

et al. 2017

ecancer

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Measurement of incidence rates of childhood cancer in Africa is difficult. The study ‘Cancer of Childhood in sub Saharan Africa’ brings together results from 16 population-based registries which, as members of the African Cancer Registry Network (AFCRN), have been evaluated as achieving adequate coverage of their target population. The cancers are classified according to the third revision of the International Classification of Childhood Cancer (ICCC-3) and recorded rates in Africa are compared with those in childhood populations in the UK, France, and the USA.It is clear that, in many centres, lack of adequate diagnostic and treatment facilities leads to under-diagnosis (and enumeration) of leukaemias and brain cancers. However, for several childhood cancers, incidence rates in Africa are higher than those in high-income countries. This applies to infection-related cancers such as Kaposi sarcoma, Burkitt lymphoma, Hodgkin lymphoma and hepatocellular carcinoma, and also to two common embryonal cancers - retinoblastoma and nephroblastoma. These (and other) observations are unlikely to be artefact, and are of considerable interest when considering possible aetiological factors, including ethnic differences in risk (and hence genetic/familial antecedents).The data reported are the most extensive so far available on the incidence of cancer in sub Saharan Africa, and clearly indicate the need for more resources to be devoted to cancer registration, especially in the childhood age range, as part of an overall programme to improve the availability of diagnosis and treatment of this group of cancers, many of which have—potentially—an excellent prognosis.

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Section: Results and Discussion – By Type Of Cancermentioning

confidence: 99%

Cancer of childhood in sub-Saharan Africa

Stefan¹,

Bray²,

Ferlay³

et al. 2017

ecancer

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“…These miRNAs targets are involved in gene expression, proliferation, and DNA modification. In MYC translocation-negative, overexpression of DNA methyltransferase (DNMT) was associated with hypoexpression of the miR-29 family [ 132 ]. Association between high expression of DNMT1 and decrease in the miR-29 family was observed in a pediatric cohort ( n = 71), suggesting a methylation control of has-miR-29 [ 133 ].…”

Section: Lymphomasmentioning

confidence: 99%

MiRNA Dysregulation in Childhood Hematological Cancer

Oliveira

Roberto

Baroni

et al. 2018

IJMS

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For decades, cancer biology focused largely on the protein-encoding genes that have clear roles in tumor development or progression: cell-cycle control, apoptotic evasion, genome instability, drug resistance, or signaling pathways that stimulate growth, angiogenesis, or metastasis. MicroRNAs (miRNAs), however, represent one of the more abundant classes of cell modulators in multicellular organisms and largely contribute to regulating gene expression. Many of the ~2500 miRNAs discovered to date in humans regulate vital biological processes, and their aberrant expression results in pathological and malignant outcomes. In this review, we highlight what has been learned about the roles of miRNAs in some of the most common human pediatric leukemias and lymphomas, along with their value as diagnostic/prognostic factors.

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“…B cell lymphomas exhibit DNA methylation heterogeneity. The methyltransferase DNMT1, which plays a role in germinal center B cells, is significantly increased in Burkitt lymphoma primary tumor samples compared with healthy lymph node tissues (56,57) and in DLBCL patient cases (58,59). Furthermore, MLL-rearranged acute lymphoblastic leukemias also exhibit loss of DNA methylation at enhancers of critical transcription factors (60), highlighting the importance of understanding the multiple layers of epigenetic regulation in lymphoma and leukemia formation and in developing treatments that target either histone or DNA methylation (recently reviewed in Ref.…”

Section: Epigenetic Modifiers Regulate Cell Fate Decisions During Immmentioning

confidence: 99%

Disrupting the Code: Epigenetic Dysregulation of Lymphocyte Function during Infectious Disease and Lymphoma Development

Pietro

Good-Jacobson

2018

The Journal of Immunology

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Lymphocyte differentiation and identity are controlled by signals in the microenvironment that ultimately mediate gene expression in the nucleus. Although much focus has centered on the strategic and often unique roles transcription factors play within lymphocyte subsets, it is increasingly clear that another level of molecular regulation is crucial for regulating gene expression programs. In particular, epigenetic regulation is critical for appropriately regulated temporal and cell-type-specific gene expression during immune responses. As such, mutations in epigenetic modifiers are linked with lymphomagenesis. Furthermore, certain infections can remodel the epigenome in host cells, either through the microenvironment or by directly co-opting host epigenetic mechanisms, leading to inappropriate gene expression and/or ineffective cellular behavior. This review will focus on how histone modifications and DNA methylation, and the enzymes that regulate the epigenome, underpin lymphocyte differentiation and function in health and disease.

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Burkitt lymphoma beyond MYC translocation: N-MYC and DNA methyltransferases dysregulation

Cited by 26 publications

References 53 publications

Cancer of childhood in sub-Saharan Africa

Cancer of childhood in sub-Saharan Africa

MiRNA Dysregulation in Childhood Hematological Cancer

Disrupting the Code: Epigenetic Dysregulation of Lymphocyte Function during Infectious Disease and Lymphoma Development

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