Burkitt lymphoma and diffuse large B-cell lymphoma: a unique case of a composite lymphoma of different clonal origin

Distinct genetic alterations in Burkitt-like lymphoma with 11q aberration and Burkitt lymphoma: a novel case report of composite lymphoma

“…Considering that categorization of BLL-11q as a variant of BL, DLBCL or another distinct form of large B-cell lymphoma remains uncertain, the present case is significant in keeping with previous reports in terms of supporting the perspective that BLL-11q is a distinct entity from BL. 8,12 This sheds light on the lymphomagenesis of CL that may originate from non-immunoglobulin gene-rearranged common progenitor cells.…”

“…Horing et al reported CL of DLBCL and BL in ileocecal area which was similar site with our case exhibiting two separate clonal population on IgH gene rearrangement analysis. 8 Considering that genetic alteration of the case was not fully examined in detail and several cases of BLL-11q have been morphologically indistinguishable from DLBCL, the prior case of CL at the same site may provide a clue for understanding pathogenesis of large B-cell lymphoma. 9,10 Although BLL-11q has been described to resemble BL on morphological, immunophenotypic and gene-expression levels, it lacks MYC rearrangements and has a chromosome 11q alteration characterized by proximal gains and telomeric losses: specifically, interstitial gains including a minimal region of gain in 11q23.2-23.3 and losses of 11q24.1-qter.…”