Burden of Specialist-Diagnosed Chronic Cough in Adults

Zeiger, Robert S.; Schatz, Michael; Butler, Rebecca K.; Weaver, Jessica; Bali, Vishal; Chen, Wansu

doi:10.1016/j.jaip.2020.01.054

Cited by 46 publications

(66 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, sites were across the provinces. Fifth, individuals visiting speciality clinics for chronic cough are likely to have more severe symptoms or are to experience more negative outcomes than those who do not attend speciality clinics [ 10 , 13 ]. Thus, population-based studies may not be generalisable to patients in chronic cough clinics.…”

Section: Discussionmentioning

confidence: 99%

“…The estimated 10% of adults globally with chronic cough report adverse psychosocial and physical effects such as exhaustion, depression, and disruptions to social interactions, sleep, and work [5][6][7][8] . Chronic cough is one of the most common reasons for referral to a specialist in secondary care, representing a significant burden on the health care system 9,10 . Quantitative assessments of the prevalence, incidence and characteristics features of chronic cough help to identify at risk populations, potentially causative factors, and reflects the burden of chronic cough in the general population.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Prevalence, incidence and characteristics of chronic cough among adults from the Canadian Longitudinal Study on Aging

et al. 2021

View full text Add to dashboard Cite

The global prevalence of chronic cough(CC) is highly variable ranging from 2–18%. There is a lack of data on the prevalence and incidence of CC from the general population. The objective of this study was to investigate the prevalence and incidence of CC in a sample of Canadian adults, and how these influenced by age, sex, smoking, respiratory symptoms, medical co-morbidities, and lung function.Participants with chronic cough were identified from the Canadian Longitudinal Study on Ageing (CLSA) based on a self-reported daily cough in the last 12 months. This is a prospective, nationally generalisable, stratified random sample of adults aged 45–85 at baseline recruited between 2011–2015, and followed-up 3 years later. The prevalence and incidence per-100-person-years are described, with adjustments for age, sex and smoking.Of the 30 097 participants, 29 972 completed the CC question at baseline and 26 701 at follow-up. The prevalence of CC was 15.8% at baseline and 17.6% at follow-up with 10.4%–17.1% variation across 7 provinces included in the CLSA comprehensive sample. Prevalence increased with age, current smoking, and was higher in males(15.2%), Caucasians(14%), and those born in North America, Europe or Oceania(14%). The incidence of CC adjusted for age, sex and smoking was higher in males, underweight and obese. Respiratory symptoms, airways diseases, lower FEV1%predicted, cardio-vascular diseases, psychological disorders, diabetes and chronic pain had a higher incidence of CC.The prevalence and incidence of CC is high in the CLSA sample with geographic, ethnic and gender differences which is influence by a number of medical co-morbidities.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Prevalence, incidence and characteristics of chronic cough among adults from the Canadian Longitudinal Study on Aging

et al. 2021

View full text Add to dashboard Cite

show abstract

“…There is poor recognition that CC can be refractory to treatment of associated conditions or unexplainable; thus, patients with CC are frequently labeled as having other conditions, and such confusion often leads to multiple diagnoses being suspected [9,10]. Diagnostic uncertainty may lead to repetitive medical consultations, fruitless investigations, and unnecessary Lung (2021) 199:121-129 1 3 treatment trials [4,11,12]. Patient burden is exacerbated by the current paucity of effective and safe treatment options for these patients, with no available pharmacologic treatments having approved indications for CC.…”

Section: Introductionmentioning

confidence: 99%

“…An understanding of the typical profile of patients with CC is important to recognize the unique features of such patients. Epidemiologic studies have revealed typical features of patients with CC, including a preponderance of females who have never smoked [4,11,[19][20][21]. The prevalence of CC peaks around middle age (i.e., in the fifth and sixth decades), though CC can occur in all age groups [22].…”

Section: Introductionmentioning

confidence: 99%

Characterization of Patients With Refractory or Unexplained Chronic Cough Participating in a Phase 2 Clinical Trial of the P2X3-Receptor Antagonist Gefapixant

Morice

Birring

Smith

et al. 2021

Lung

View full text Add to dashboard Cite

Purpose This analysis assesses clinical characteristics of patients with refractory chronic cough (RCC) or unexplained chronic cough (UCC) enrolled in a phase 2 study to better understand this patient population. Methods Patients with RCC/UCC lasting for ≥ 1 year and cough severity visual analog scale (VAS) score of > 40 mm at screening were eligible. Demographics, clinical characteristics, and medical history were collected at baseline. Cough-related measures included cough severity VAS, Cough Severity Diary (CSD), Leicester Cough Questionnaire (LCQ), and a structured cough-trigger questionnaire. Medication history included all medications 30 days before screening and chronic cough treatments within 1 year before screening. Data were summarized using descriptive statistics. Results Patients (N = 253; female, 76%; mean age, 60 years) had severe (mean cough severity VAS, 57.5 mm) and long-lasting (median duration, 11 years) cough. The most burdensome self-reported aspects included psychological and social factors (LCQ) and cough frequency and intensity (CSD). Patient-reported triggers were consistent with cough hypersensitivity (e.g., 95% to 96% reported irritation or tickle in throat). Common reported comorbidities included gastroesophageal reflux disease (GERD; 56%), allergic rhinitis (47%), and asthma (30%); 12% of patients had been diagnosed with all 3 conditions. The most common prior medications included inhaled or oral steroids (21%), antihistamines (15%), and antacids (15%). Conclusion Patients with RCC/UCC had severe, long-lasting, and burdensome cough with clinical features of cough hypersensitivity. Many patients had been diagnosed with GERD, allergic rhinitis, and asthma but had a persistent cough despite treatment of these conditions. Trial registration: ClinicalTrials.gov, NCT02612610; registered November 20, 2015

show abstract

“…10 Zeiger et al reported that among specialist-diagnosed CC patients 44.1% exhibited GERD, 31.2% asthma, 24.3% obesity, 20.4% upper airway cough syndrome and 19.4% common cough complications. 11 Certain patients may continue to cough despite thorough investigation and treatment, in cases where no cause can be determined (termed unexplained chronic cough, idiopathic chronic cough) or when cough persists despite treatment of existing underlying conditions (refractory chronic cough). 12 Increased exposure of the sensory nerve terminals to chemical irritants (e.g., PGE2, ATP) or excess mucus may have a role in triggering cough.…”

Section: Introductionmentioning

confidence: 99%

Chronic cough in Germany: results from a general-population survey

Virchow

Fonseca

et al. 2021

ERJ Open Res

View full text Add to dashboard Cite

BackgroundChronic cough (CC) which is defined≥8 weeks is a common condition in clinical practice. However, estimates of prevalence and associated comorbidities in German adults and key subgroups of age and gender are lacking.MethodsCross-sectional study based on a representative panel of 15,020 adult subjects of the general population who completed the German National Health and Wellness Survey, reporting chronic cough and questions about comorbidities. Lifetime and 12-month prevalence are presented as unweighted estimates.ResultsThe lifetime CC prevalence was 6.5% (range across age groups, 5.1%–8.3%) and the 12-month prevalence was 4.9% (range 3.7–5.7%). The prevalence of diagnosed CC was 2.8% (range, 0.9–4.1%) and the prevalence of persons currently on any prescription to treat CC was 0.6% (range 0.2–1.4%). Respondents who experienced CC were 52.0±17.0 years old, with a higher prevalence in those aged 50 years and older. Persons with CC had higher morbidity scores and were diagnosed with an increased number of comorbidities, most frequently diagnoses of the respiratory system (71.0%), followed by digestive tract (34.0%) disorders and sleep disorders (37.6%).ConclusionsIn a broadly representative sample of German adults, lifetime and 12-month prevalence of CC was greatest in current and former smokers and those older≥50 years of age. Comorbidities are frequent and may complicate management of these patients.

show abstract

Burden of Specialist-Diagnosed Chronic Cough in Adults

Cited by 46 publications

References 50 publications

Prevalence, incidence and characteristics of chronic cough among adults from the Canadian Longitudinal Study on Aging

Prevalence, incidence and characteristics of chronic cough among adults from the Canadian Longitudinal Study on Aging

Characterization of Patients With Refractory or Unexplained Chronic Cough Participating in a Phase 2 Clinical Trial of the P2X3-Receptor Antagonist Gefapixant

Chronic cough in Germany: results from a general-population survey

Contact Info

Product

Resources

About