Burden of Psychiatric Disorders among Pediatric and Young Adults with Inflammatory Bowel Disease: A Population-Based Analysis

Abstract

PurposeThere is increasing prevalence of psychiatric disorders among inflammatory bowel Disease (IBD) population. Further, presence of psychiatric disorders has been shown as an independent predictor of quality of life among patients with IBD. We intended to explore the prevalence of various psychiatric disorders among pediatric and young adult population with IBD as a population-based analysis.MethodsWe did a retrospective case control analysis using a deidentified cloud-based database including health care data across 26 health care networks comprising of more than 360 hospitals across USA. Data collected across different hospitals were classified and stored according to Systematized Nomenclature of Medicine-Clinical Terms. We preidentified 10 psychiatric disorders and the queried the database for the presence of at least one of the ten psychiatric disorders among IBD patients between 5 and 24 years of age and compared with controls.ResultsTotal of 11,316,450 patients in the age group between 5 and 24 years and the number of patients with a diagnosis of IBD, Crohn's disease or ulcerative colitis were 58,020. The prevalence of psychiatric disorders was 21.6% among IBD mainly comprising of depression and anxiety disorder. Multiple logistic regression analysis showed, IBD is 5 times more likely associated with psychiatric disorders than controls, p<0.001). We showed a steady increasing trend in the incidence of psychiatric disorders among IBD patients (2% in 2006 to 15% in 2017).ConclusionLargest population-based analysis demonstrated an increased prevalence of psychiatric disorders among IBD patients. Our study emphasizes the need for psychological and mental health services to be incorporated as a part of the routine IBD clinic.

Association Between Inflammatory Bowel Disease and Psychiatric Morbidity and Suicide: A Swedish Nationwide Population-Based Cohort Study With Sibling Comparisons

“…An increased risk of overall psychiatric disorders [HR = 3.8] has recently been reported in young [aged 5–24 years] IBD patients. 40 However, because the authors did not report the age of IBD onset, it remains unclear how many of these represent adult-onset IBD. 40 In 2019, Bernstein et al .…”

“… 40 However, because the authors did not report the age of IBD onset, it remains unclear how many of these represent adult-onset IBD. 40 In 2019, Bernstein et al . 41 followed 6199 incident cases of adult-onset IBD in Canada.…”

Emerging Comorbidities in Inflammatory Bowel Disease: Eating Disorders, Alcohol and Narcotics Misuse

“…Increased risk for SUDs was demonstrated in studies in paediatric and young adults with IBD [ 95 ]. It is worth noting that in another study in adolescents and young adults with IBD majority of them (76/132) were abstainers; however, those reporting usages of marihuana and binge drinking episodes have been also smoking cigarettes [ 96 ].…”

Common infections, mental health problems and healthcare use in people with inflammatory bowel disease: a cohort study protocol

“…10 In a recent population-based study in the USA, among 12 540 patients with IBD aged 5-24 years, the prevalence of psychiatric disorders was 21.6%, compared with 6% among controls. 11 In a systematic review of ~150 000 patients with IBD, the pooled prevalence of depression and anxiety symptoms was 15.2% and 20.5%, respectively, with higher rates of both observed in CD versus UC. 10 In a population-based survey in the USA, the prevalence of depression was 16%, resulting in a mean annual IBD-related increase in healthcare costs of $17 706 compared with patients with IBD without depression.…”