Burden of potentially human papillomavirus-associated cancers of the oropharynx and oral cavity in the US, 1998-2003

Ryerson, A. Blythe; Peters, Edward S.; Coughlin, Steven S.; Chen, Vivien W.; Gillison, Maura L.; Reichman, Marsha E.; Wu, Xiao‐Cheng; Chaturvedi, Anil K.; Kawaoka, Kelly

doi:10.1002/cncr.23745

Cited by 269 publications

(234 citation statements)

References 36 publications

(67 reference statements)

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“…For anal cancer, studies from the US, 19 Australia 20 and several European countries 12,[21][22][23] have reported an increase in incidence over time. As was also observed in our study, the incidence of anal cancer in most countries is higher among women than among men.…”

Section: Cmaj Openmentioning

confidence: 99%

Trends in the incidence of human papillomavirus-related noncervical and cervical cancers in Alberta, Canada: a population-based study

Shack¹,

Lau²,

Huang³

et al. 2014

CMAJ Open

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CMAJ OPEN, 2(3) E127 Research CMAJ OPENA ccording to world-wide estimates, human papillomavirus (HPV) infection is responsible for 5.2% of all cancers. 1,2 The association between HPV and cervical cancer has been well-known for many decades, but the link between HPV and cancers of the anus, penis, vagina, vulva and oropharynx has only recently been confirmed.3 Cervical cancer rates have been declining in Canada and the United States, consistent with the successful adoption of Papanicolaou smear screening programs, 4,5 but the incidence of other HPV-related cancers has been increasing. The increasing incidence of these HPV-related cancers has been attributed to changes in lifestyle-related risk factors, most notably sexual behaviour.5 Analysis of trends in incidence and birth cohorts in both the US and the United Kingdom have shown an increased risk of HPV-related cancer in more recent birth cohorts and recent time periods, 5,6 and these increases have been attributed to generational changes in sexual patterns and increased exposure to HPV. 6 HPV vaccines are now broadly used in the prevention of cervical cancer. In Alberta, HPV vaccination programs were implemented in 2008 and, as in many other jurisdictions, have been funded only for females. Although HPV vaccination programs may reduce the incidence of HPV-related cancers other than cervical cancer, 6 they remain the subject of much public policy debate in Canada. 7 In this study, we sought to examine trends in noncervical HPV-related cancers over time and compare them with relative changes in cervical cancer and non-HPV-related cancers with similar risk factors.

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Section: Cmaj Openmentioning

confidence: 99%

Trends in the incidence of human papillomavirus-related noncervical and cervical cancers in Alberta, Canada: a population-based study

Shack¹,

Lau²,

Huang³

et al. 2014

CMAJ Open

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“…4 Internationally, incidence rates of oral cavity and oropharyngeal cancers vary widely and tend to be highest where alcohol and tobacco exposure (whether smoked or chewed) is high. 53 In the USA, rates of HPV-related oral squamous cell carcinomas increased during 1973-2004, whereas the incidence of HPV-unrelated oral cavity squamous cell carcinomas declined, 4,54 probably in relation to declining cigarette consumption. 55 Incidence has increased most dramatically for tonsillar cancer, 56,57 the oral cancer site most closely linked with HPV infection.…”

Section: Oral Cavity and Oropharyngeal Cancersmentioning

confidence: 99%

Cancers attributable to human papillomavirus infection

et al. 2010

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Abstract. Although the human papillomavirus (HPV) vaccine was introduced primarily as a cervical cancer prevention vaccine, HPV has a causal role in several types of cancer. This article reviews the epidemiological evidence for the role of HPV in human cancer, and describes Australian trends in these cancers. HPV is a necessary cause of cervical cancer. The currently vaccine-preventable subtypes of HPV 16 and 18 are responsible for~70% of cervical cancer. The introduction of an organised Pap smear program in Australia led to a steep decline in incidence over the past decades. HPV can be detected in~40% and 70% of vulval and vaginal cancers respectively. Rates of these cancers have been stable over the past 20 years. The prevalence of HPV in penile cancer is~50% and incidence has not recently changed. For anal cancer,~85% of cases are HPV positive, and incidence has increased significantly in both men and women over the past 20 years. In the oral cavity,~35% of oropharyngeal cancers and~25% of other oral cavity cancers are HPV positive. The incidence of HPV-related oral cavity and oropharyngeal cancers is increasing, whereas incidence at HPV-unrelated sites is decreasing. Overall, 1154 HPV-related cancer cases were potentially preventable by vaccination. If HPV-related cancers at non-cervical sites are prevented by vaccination, then a similar number of cancer cases will be prevented as in the cervix. However, almost one-quarter of the potentially preventable cancer cases are in men, who are not included in the current national immunisation program.

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“…The annual percentage increase for the incidence of tonsil/tongue base SCC is ?3.0% (p \ 0.05) [34]. A four-fold increased incidence of tonsillar SCC is observed for woman , as compared to the 1.3 fold increase for men [35].…”

Section: Human Papillomavirusmentioning

confidence: 99%

Prognostic Indicators in Head and Neck Oncology Including the New 7th Edition of the AJCC Staging System

Brandwein-Gensler

Smith

2010

Head and Neck Pathol

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Burden of potentially human papillomavirus-associated cancers of the oropharynx and oral cavity in the US, 1998-2003

Cited by 269 publications

References 36 publications

Trends in the incidence of human papillomavirus-related noncervical and cervical cancers in Alberta, Canada: a population-based study

Trends in the incidence of human papillomavirus-related noncervical and cervical cancers in Alberta, Canada: a population-based study

Cancers attributable to human papillomavirus infection

Prognostic Indicators in Head and Neck Oncology Including the New 7th Edition of the AJCC Staging System

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