Burden of Pertussis in Adults Aged 50 Years and Older: A Retrospective Database Study in England

Abstract

Introduction Pertussis, a highly infectious respiratory disease caused by Bordetella pertussis , affects people of all ages. Older adults are particularly susceptible to its severe outcomes and complications. Methods In this retrospective cohort study, the incidence rate of pertussis among individuals aged ≥ 50 years was assessed during 2009–2018 using Clinical Practice Research Datalink and Hospital Episode Statistics databases, United Kingdom. Health care resource utilisation (HCRU) and direct medical costs (DMCs) were compared between patients with a pertussis diagnosis and propensity score-matched controls (matched on demographic and clinical variables). Results Among 5,222,860 individuals, 1638 had a pertussis diagnosis (incidence rate: 5.8 per 100,000 person-years; 95% confidence interval 5.5–6.0). Baseline (– 18 to – 6 months) HCRU and DMC were similar among 1480 pertussis patients and 1480 matched controls. However, there were increases in HCRU in the pertussis vs. matched cohort around the pertussis diagnosis (from months – 6 to – 1 to 5–11). The most notable increases (pertussis vs. controls) were in the rates of general practitioner (GP)/nurse visits (4.7-fold), clinical assessments (4.1-fold), and accident and emergency visits (3.0-fold) during the month before diagnosis and GP/nurse visits during the 2 months after diagnosis (2.5-fold) (all p < 0.001). DMCs were significantly higher in the pertussis cohort ( p < 0.001). Total excess DMC in the pertussis cohort during months – 1 to + 11 was £318 per patient. Conclusion A pertussis diagnosis among adults aged ≥ 50 years resulted in significant increases in HCRU and DMC across several months around diagnosis. These results highlight the need for increased awareness of pertussis infection among adults aged ≥ 50 years and suggest that pertussis booster doses among this population should be considered. Supplementary Information The online version contains supplementary material available at 10.1007/s40121-023-00774-5.

Assessing the Underestimation of Adult Pertussis Disease in Five Latin American Countries

“…The age distribution of pertussis in adults aged 50 years or over was adapted from a study in England [ 25 ] (Table 3 ). The age distribution for pertussis hospitalizations was adapted from a separate published study in Australia [ 26 ] (Table 3 ).…”