Burden of pancreatitis and associated risk factors in China, 1990 to 2019: a systematic analysis for the Global Burden of Disease Study 2019

Han, Ke; Chen, Shimin; Song, Yang; Du, Chen; Gao, Fei; Liu, Shaohua; He, Yao; Chai, Ningli; Linghu, Enqiang; Liu, Miao

doi:10.1097/cm9.0000000000002164

Cited by 9 publications

(5 citation statements)

References 38 publications

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“…A 10-year retrospective study from China found that the estimate number of death caused by alcoholinduced AP was 3327.29 in 2019. Meanwhile, the disease burden caused by alcohol use was most serious among young and middle-aged male, reaching the highest value in the age group of 35 to 54 [28]. In our study, the average age in RAP group was 49.69 years, which was consistent with the above results.…”

Section: Discussionsupporting

confidence: 91%

Prediction and evaluation of a nomogram model for recurrent acute pancreatitis

Chen,

Huang,

Luo

et al. 2024

European Journal of Gastroenterology &Amp; Hepatology

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Objective The purpose of this study was to investigate the influencing factors for recurrent acute pancreatitis and construct the nomogram model to predict the risk of recurrent acute pancreatitis. Methods Patients diagnosed with acute pancreatitis in the Affiliated Hospital of Southwest Medical University were enrolled. We collected these patients’ basic information, laboratory data, imaging information. Using Logistic regression and least absolute shrinkage and selection operator regression to select risk factor for Cross-Validation Criterion. To create nomogram and validated by receiver operator characteristic curve, calibration curves and decision curve analysis. Results A total of 533 patients with acute pancreatitis were included, including 99 recurrent acute pancreatitis patients. The average age of recurrent acute pancreatitis patients was 49.69 years old, and 67.7% of them were male. At the same time, in all recurrent acute pancreatitis patients, hypertriglyceridemic pancreatitis is the most important reason (54.5%). Regression analysis and least absolute shrinkage and selection operator regression showed that smoking history, acute necrotic collection, triglyceride, and alcohol etiology for acute pancreatitis were identified and entered into the nomogram. The area under the receiver operator characteristic curve of the training set was 0.747. The calibration curve showed the consistency between the nomogram model and the actual probability. Conclusion In conclusion, some high-risk factors like smoking history, acute necrotic collection, triglyceride, and alcohol etiology for acute pancreatitis may predict recurrent pancreatitis and their incorporation into a nomogram has high accuracy in predicting recurrence.

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Section: Discussionsupporting

confidence: 91%

Prediction and evaluation of a nomogram model for recurrent acute pancreatitis

Chen,

Huang,

Luo

et al. 2024

European Journal of Gastroenterology &Amp; Hepatology

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“…GBD data show an upward trend in SDI in China, increasing from 0.456 in 1990 to 0.707 in 2017. Since 2003, China's SDI has exceeded the global average (37). The increase observed in the annual incidence and number of patients over the 30-year period of this study may be explained by advances in TC diagnosis as well as the increase in the total population in China.…”

Section: Discussionmentioning

confidence: 65%

Thyroid cancer burden and risk factors in China from 1990-2019: a systematic analysis using the global burden of disease study

Jin,

Luo,

et al. 2023

Front. Oncol.

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BackgroundThyroid cancer (TC) is the most common endocrine system malignancy with a rapidly increasing incidence in China. Epidemiological data on TC at the national level are lacking. This study aimed to quantify the TC disease burden in China between 1990 and 2019 and evaluate the current status and trends of the disease burden attributed to a high body mass index (HBMI).MethodsThe 2019 Global Burden of Disease Study dataset was used to explore the TC disease burden. Age-standardized rates of incidence (ASIR), prevalence (ASPR), deaths (ASDR), and disability-adjusted life years (DALYs) were considered and the estimated annual percentage change (EAPC) was calculated as a measure of the average change in age-standardized rates. The trend in TC-related mortality and DALYs attributed to an HBMI, accounting for different age groups and sexes, was examined.ResultsBetween 1990 and 2019, the ASDR and DALYs for TC decreased by 0.02/100000 and 1.17/100000, respectively. The ASPR and ASIR increased by 9.88/100000 and 1.04/100000, respectively. The EAPC for ASDR, age-standardized rates of DALYs, ASPR, and ASIR were 0.06 (95% CI: -0.09, 0.21), -0.20 (95% CI: -0.31, -0.10), 3.52 (95% CI: 3.35, 3.68), and 2.73 (95% CI: 2.58, 2.88), respectively. TC-related deaths, DALYs, and their prevalence and incidence in China increased by 118%, 350%, 81%, and 290%, respectively. The disease burden of TC was higher among male than female patients in different age groups, with varying distributions. The disease burden attributed to HBMI gradually increased over the past 30 years according to age-standardized DALYs, particularly in male patients.ConclusionThe TC burden has increased in China over the past 30 years, and population aging poses a challenge to TC prevention and control. HBMI has become an important factor in the TC disease burden and further research should focus on reducing the disease burden among Chinese male patients with TC.

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“…East Asia, South Asia, and Western Europe had the highest cases [ 6 ]. According to a meta-analysis study, the global incidence of acute pancreatitis (AP) was 33.74, and those of chronic pancreatitis (CP) were 9.62 per 100,000 population per year [ 7 ]. The mortality in patients with AP was 1.60/100,000, and mortality in patients with CP was 0.09/100,000.…”

Section: Introductionmentioning

confidence: 99%

“…The mortality in patients with AP was 1.60/100,000, and mortality in patients with CP was 0.09/100,000. In 2019, it was estimated that the global incidence, disability-adjusted life years, and pancreatitis patient mortality were 34.8/100,000 and 1.4/100,000, respectively [7]. Several studies have demonstrated that AP patients may eventually develop chronic symptoms [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Unraveling Proto-Oncogene (ErbB2) Expression in Patients With Carcinoma Head of Pancreas and Chronic Pancreatitis Patients: A Case-Control Study

Mohanan,

Biju,

et al. 2024

Cureus

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Background The pre-malignant tendency of the normal, non-affected portion of the pancreas is not as well explored as the multicentricity documented in pancreatic cancer cases. In order to ascertain the expression of inflammatory markers and Erythroblastic Oncogene B ( ErbB2 ) in the non-affected pancreas in patients with pancreatic cancer, a case-control study was carried out. Materials and methods In patients who underwent pancreatoduodenectomy for pancreatic cancer (PC), pro-inflammatory genes and a tumor marker, erythroblastic oncogene 2 ( ErbB2 ) in the epidermal growth factor receptor family were analyzed in the pancreatic tissue at the cut surface of the normal pancreas using qRT-PCR. Twenty patients diagnosed with Chronic pancreatitis (CP) after Frey's surgical procedure were selected, and their pancreatic tissues were analyzed as controls. The HPLC-purified primers were designed using National Center for Biotechnology Information (NCBI) software. The primer's specificity was verified for gene expression analysis using the Basic Local Alignment Search Tool (BLAST). The genes under study were normalized using β-actin as the housekeeping gene, and the 2 -ddct method was used to compute the fold change compared to the control sample. Results Patients with margin-positive were not included. Pro-inflammatory genes ( TNF-α, NF-kβ, and COX-2 ) had significantly lower foldchange in PC patients compared to the CP group. The CP control group had higher levels of IL-6 gene expression than the PC group. Patients with pancreatic cancer had a considerably higher expression of the ErbB2 gene than patients with CP. Conclusion The upregulated ErbB2 gene in the unaffected pancreatic tissue of pancreatic cancer patients, when compared to controls, indicates that the remaining pancreas may have the capacity to cause cancer. Proto-oncogene may play a role in the pathophysiologic process in patients with pancreatic cancer.

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Burden of pancreatitis and associated risk factors in China, 1990 to 2019: a systematic analysis for the Global Burden of Disease Study 2019

Cited by 9 publications

References 38 publications

Prediction and evaluation of a nomogram model for recurrent acute pancreatitis

Prediction and evaluation of a nomogram model for recurrent acute pancreatitis

Thyroid cancer burden and risk factors in China from 1990-2019: a systematic analysis using the global burden of disease study

Unraveling Proto-Oncogene (ErbB2) Expression in Patients With Carcinoma Head of Pancreas and Chronic Pancreatitis Patients: A Case-Control Study

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