Burden of osteoporosis in Vietnam: An analysis of population risk

Abstract

Purpose To estimate the proportion of men and women aged 50 years and older who would be classified as "high risk" for fracture and eligible for anti-fracture treatment. Methods The study involved 1421 women and 652 men aged 50 years and older, who were recruited from the general population in Ho Chi Minh City, Vietnam. Fracture history was ascertained from each individual. Bone mineral density (BMD) was measured at the lumbar spine and femoral neck by DXA (Hologic Horizon). The diagnosis of osteoporosis was based on the T-scores ≤ -2.50 derived from either femoral neck or lumbar spine BMD. The 10-year risks of major fractureand hip fracture were estimated from FRAX version for Thai population. The criteria for recommended treatment were based on the US National Osteoporosis Foundation (NOF). Results The average age of women and men was ~60 yr (SD 7.8). Approximately 11% (n = 152) of women and 14% (n = 92) of men had a prior fracture. The prevalence of osteoporosis was 27% (n = 381; 95% CI, 25 to 29%) in women and 13% (n = 87; 95% CI, 11 to 16%) in men. Only 1% (n = 11) of women and 0.1% (n = 1) of men had 10-year risk of major fracture ≥ 20%. However, 23% (n = 327) of women and 9.5% (n = 62) of men had 10-year risk of hip fracture ≥ 3%. Using the NOF recommended criteria, 49% (n = 702; 95% CI, 47 to 52%) of women and 35% (n = 228; 95% CI, 31 to 39%) of men would be eligible for therapy. Conclusion Almost half of women and just over one-third of men aged 50 years and older in Vietnam meet the NOF criteria for osteoporosis treatment. This finding can help develop guidelines for osteoporosis treatment in Vietnam.

Low bone mineral density and its related factors in adults with congenital heart disease in Vietnam: A cross‐sectional study

“…Although our study included young patients with a mean age of 32.4 years, osteoporosis prevalence was similar to that of the reference older Vietnamese population (≥50 years), that is, one‐third of patients had osteoporosis in both sexes. 19 Notably, our linear regression model showed weak relationships between age and BMD at most sites in both sexes. Current observations indicate that osteoporosis prevalence increases with age.…”

“…Although our study included young patients with a mean age of 32.4 years, osteoporosis prevalence was similar to that of the reference older Vietnamese population (≥50 years), that is, one-third of patients had osteoporosis in both sexes. 19 20 The equal prevalence of osteoporosis in our younger patients and the older reference population and weak effect size of age to BMD suggest that, in addition to age, there are hidden risk factors for osteoporosis in adults with CHD.…”

Volatile Constituents and Anti-Osteoporotic Activity of the n-Hexane Extract From Homalomena gigantea Rhizome

“…8,9 In Vietnam, both men and women are at high risk of osteoporosis. [10][11][12][13] Alendronate, etidronate, ibandronate, and risedronate are only a few of the medications being increasingly used to treat and prevent osteoporosis in postmenopausal women and those taking chronic corticosteroids. However, these drugs have numerous side effects, including hypocalcemia, kidney impairment leading to renal failure, and gastrointestinal symptoms (nausea, indigestion, and diarrhea).…”

Quality improvement initiatives in the care and prevention of fragility fractures in the Asia Pacific region

“…Key findings of recent epidemiological studies from countries and regions in the Asia Pacific[15][16][17][18][19][20][21][22][23][24][25][26][27][28][29] …”

“…continued) Country or region Population Study purpose and key findings Reference Vietnam A total of 2073 women and men aged 50 years or older from the general population of Ho Chi Minh City Purpose: To estimate the proportion of women and men aged 50 years who would be at high fracture risk and eligible for osteoporosis treatment Key findings included: • A history of prior fracture was evident among 11% of women and 14% of men • 27% (95% CI: 25-29%) of women and 13% (95% CI: 11-16%) of men had a diagnosis of osteoporosis based on T-scores ≤ − 2.5 from either the femoral neck or lumbar spine• 23% of women and 9.5% of men had 10-year risk of hip fracture ≥ 3%Hoang et al 2021[29] teriparatide.…”