Burden of Obesity on Pediatric Inpatients with Acute Asthma Exacerbation in the United States

Okubo, Yusuke; Nochioka, Kotaro; Hataya, Hiroshi; Sakakibara, Hiroshi; Terakawa, Toshiro; Testa, Marcia A.

doi:10.1016/j.jaip.2016.06.004

Cited by 81 publications

(76 citation statements)

References 26 publications

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“…Studies showed obesity led to greater illness severity in patients with asthma . Nationwide studies in the USA revealed that obesity was associated with the use of non‐invasive or invasive mechanical ventilation among hospitalized children with acute asthma exacerbation (odds ratio, 1.59; 95% CI, 1.28‐1.99) .…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, this study aimed to investigate the relationship between obesity and repeated admissions in hospitalized children with acute asthma exacerbation, using a national inpatient database in Japan. In addition, we evaluated the impact of obesity on healthcare costs, length of hospital stay, and risk of intensive care, and compared the results with those in previous studies …”

Section: Introductionmentioning

confidence: 99%

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Impact of pediatric obesity on acute asthma exacerbation in Japan

Okubo

Michihata

Yoshida

et al. 2017

Pediatric Allergy Immunology

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Impact of pediatric obesity on acute asthma exacerbation in Japan

Okubo

Michihata

Yoshida

et al. 2017

Pediatric Allergy Immunology

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“…In a recent analysis of over 100,000 hospitalizations for asthma, obesity was associated with higher odds of mechanical ventilation and longer length of stay 11 . Although many studies have reported differing effects of obesity on asthma by sex 15–18 , their results have been conflicting and thus further research is needed on this topic.…”

Section: “Obese Asthma” In Childhoodmentioning

confidence: 99%

The effect of obesity, weight gain, and weight loss on asthma inception and control

Forno

Celedón

2017

Current Opinion in Allergy &Amp; Clinical Immunology

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Purpose of the review There is ample and growing evidence that obesity increases the risk of asthma and morbidity from asthma. Here we review recent clinical evidence supporting a causal link between obesity and asthma, and the mechanisms that may lead to “obese asthma”. Recent findings While in some children obesity and asthma simply co-occur, those with “obese asthma” have increased asthma severity, lower quality of life, and reduced medication response. Underlying mechanistic pathways may include anatomical changes of the airways such as obstruction and dysanapsis; systemic inflammation; production of adipokines; impaired glucose-insulin metabolism; altered nutrient levels; genetic and epigenetic changes; and alterations in the airway and/or gut microbiome. A few small studies have shown that weight loss interventions may lead to improvements in asthma outcomes, but thus far research on therapeutic interventions for these children has been limited. Summary Obesity increases the risk of asthma –and worsens asthma severity or control– via multiple mechanisms. “Obese asthma” is a complex, multifactorial phenotype in children. Obesity and its complications must be managed as part of the treatment of asthma in obese children.

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“…Also noteworthy is the fact that obese paediatric in patients with acute asthma exacerbations have a significantly higher risk of requiring mechanical ventilation, higher mean total hospital charges, and longer mean length of hospital stay compared to non-obese paediatric in patients with acute asthma, according to Okubo et al [39].…”

Section: Asthma Control and Severitymentioning

confidence: 99%