Burden of nonalcoholic fatty liver disease and advanced fibrosis in a Texas Hispanic community cohort

Pan, Jen Jung; Fisher‐Hoch, Susan P.; Chen, Chaoru; Feldstein, Ariel E.; McCormick, Joseph B.; Rahbar, Mohammad H.; Fallon, Michael B.

doi:10.4254/wjh.v7.i11.1586

Cited by 22 publications

(15 citation statements)

References 17 publications

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“…Research indicates that ALT levels may decrease slightly with age ( 29 ), but our findings were nonetheless remarkable. Given the documented high rates of nonalcoholic fatty liver disease in this cohort ( 30 ), the authors believe that this association is real and that the drivers of elevated liver enzymes in young Mexican American men warrant further study.…”

Section: Discussionmentioning

confidence: 87%

The Precarious Health of Young Mexican American Men in South Texas, Cameron County Hispanic Cohort, 2004–2015

et al. 2016

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IntroductionHispanic men have higher rates of illness and death from various chronic conditions than do non-Hispanic men. We aimed to characterize the health of Mexican American men living on the US–Mexico border in South Texas and elucidate indications of chronic disease in young men.MethodsWe sampled all male participants from the Cameron County Hispanic Cohort, an ongoing population-based cohort of Mexican Americans in Brownsville, Texas. We calculated descriptive statistics and stratified the sample into 3 age groups to estimate the prevalence of sociodemographic, behavioral, and clinical factors by age group and evaluated differences between age groups.ResultsObesity prevalence was approximately 50% across all age groups (P = .83). Diabetes prevalence was high overall (26.8%), and 16.9% (95% confidence interval [CI], 10.1%–23.8%) of men younger than 35 had diabetes. More than 70% of these young men had elevated liver enzymes, and mean values of aspartate aminotransferase were significantly higher in younger men (45.0 u/L; 95% CI, 39.5–50.6 u/L) than in both older age groups. Less than 20% of young men had any form of health insurance. Current smoking was higher in young men than in men in the other groups, and the rate was higher than the national prevalence of current smoking among Hispanic men.ConclusionsWe suggest a need for obesity and diabetes prevention programs and smoking cessation programs for men in this region. Opportunities exist to expand current intervention programs and tailor them to better reach this vulnerable population of young Hispanic men. Elevated liver enzymes in men younger than 35 suggest a substantial burden of liver abnormalities, a finding that warrants further study.

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Section: Discussionmentioning

confidence: 87%

The Precarious Health of Young Mexican American Men in South Texas, Cameron County Hispanic Cohort, 2004–2015

et al. 2016

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“…Among men, neither central adiposity nor liver enzymes were significantly associated with liver stiffness. This population of men is known to have a high burden of undiagnosed liver disease (32,33) and the well-studied risk factors of obesity and diabetes may not be as predictive among Hispanic men as in other populations. As we showed in Supporting Fig.…”

Section: Discussionmentioning

confidence: 99%

Elevated Glycated Hemoglobin Is Associated With Liver Fibrosis, as Assessed by Elastography, in a Population‐Based Study of Mexican Americans

Watt

Cerda²,

Pan

et al. 2020

Hepatol. Commun.

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Diabetes is associated with liver disease and risk of hepatocellular carcinoma. In this study, we evaluated the association between liver fibrosis measured by transient elastography and four glucose metabolism measures in the Cameron County Hispanic Cohort, a population-based, randomly selected cohort of Mexican American Hispanics with high rates of diabetes and liver cancer. We measured liver fibrosis (a risk factor for hepatocellular carcinoma) in 774 wellcharacterized cohort participants using transient elastography. We evaluated the association of liver fibrosis with glycated hemoglobin (HbA1c), fasting blood glucose, insulin, and insulin resistance using multivariable linear regression models. In multivariable models, log-transformed HbA1c had the strongest association with liver fibrosis (β = 0.37, 95% confidence interval [CI] 0.04-0.69, P = 0.038), after controlling for waist circumference, aspartate aminotransferase, alanine aminotransferase, liver fat, and other known confounders. The association was statistically significant among women (β = 0.33, 95% CI 0.10-0.56, P = 0.009) and similar but nonsignificant among men (β = 0.41, 95% CI −0.17 to 0.98, P = 0.593). Waist circumference, platelet count, aspartate transaminase, and liver steatosis were each associated with liver stiffness. Conclusions: Elevated HbA1c is associated with liver fibrosis, a key risk factor for HCC, particularly among women. Our results indicate that Mexican Americans with uncontrolled HbA1c may benefit from routine screening by liver elastography to identify individuals at risk of liver disease progression. (Hepatology Communications 2020;4:1793-1801).

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“…In a study involving a Chinese population, diagnostic value of miR‐34a for NASH was superior to that of ALT, FIB‐4, and APRI in the diagnosis of fibrosis in NASH 22 . Pan et al 23 noticed that intermediate NFS and APRI scores were associated with hepatic steatosis in Hispanics, but FIB‐4 scores were not as outlined in Fig. 2.…”

Section: Disparities Secondary To Underdiagnosis and Reliability Of Dmentioning

confidence: 97%

Racial Disparities in Diagnosis and Prognosis of Nonalcoholic Fatty Liver Disease

Samji¹,

Snell

Singal

2020

Clinical Liver Disease

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Burden of nonalcoholic fatty liver disease and advanced fibrosis in a Texas Hispanic community cohort

Cited by 22 publications

References 17 publications

The Precarious Health of Young Mexican American Men in South Texas, Cameron County Hispanic Cohort, 2004–2015

The Precarious Health of Young Mexican American Men in South Texas, Cameron County Hispanic Cohort, 2004–2015

Elevated Glycated Hemoglobin Is Associated With Liver Fibrosis, as Assessed by Elastography, in a Population‐Based Study of Mexican Americans

Racial Disparities in Diagnosis and Prognosis of Nonalcoholic Fatty Liver Disease

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