Burden of non-hip–non-vertebral fractures in postmenopausal women 55 years and older. The global longitudinal study of osteoporosis in women

Old age causes de novo intracortical bone remodeling and porosity in mice

“…The increased incidence of osteoporotic fractures in elderly women and men is due to a large extent to structural deterioration of cortical bone, which represents about 80% of the skeleton (1,2). Specifically, cortical thickness decreases and porosity increases, as determined by analysis of postmortem specimens and high-resolution peripheral quantitative CT (HRpQCT) imaging of the distal radius (2)(3)(4)(5)(6)(7)(8).…”

A comprehensive fracture prevention strategy in older adults: The European union geriatric medicine society (EUGMS) statement

“…The major influence of ageing on fracture risk is mainly due to the strong impact of age and agerelated conditions on bone strength and fall risk (2,3). Although fractures of the hip are the most serious and costly fractures, those at the spine, pelvis, distal femur, proximal tibia, proximal humerus, and ribs are also major fractures, associated with excess morbidity and mortality, increased hip fracture risk, decreased quality of life, and high health care costs (4)(5)(6)(7)(8). With the global growth of the older population, prevention of fractures has become an international public health priority (4,9,10).…”

A comprehensive fracture prevention strategy in older adults: the European Union Geriatric Medicine Society (EUGMS) statement

“…The major influence of ageing on fracture risk is mainly due to the strong impact of age and age-related conditions on bone strength and fall risk [2,3]. Although fractures of the hip are the most serious and costly fractures, those at the spine, pelvis, distal femur, proximal tibia, proximal humerus, and ribs are also major fractures, associated with excess morbidity and mortality, increased hip fracture risk, decreased quality of life, and high healthcare costs [4][5][6][7][8]. With the global growth of the older population, prevention of fractures has become an international public health priority [4,9,10].…”