Burden of Liver Abscess and Survival Risk Score in Thailand: A Population-Based Study

Poovorawan, Kittiyod; Pan-ngum, Wirichada; Soonthornworasiri, Ngamphol; Kulrat, Chotipa; Kittitrakul, Chatporn; Wilairatana, Polrat; Treeprasertsuk, Sombat; Kitsahawong, Bubpha; Phaosawasdi, Kamthorn

doi:10.4269/ajtmh.16-0228

Cited by 17 publications

(17 citation statements)

References 24 publications

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“…We found that the overall mortality rate was 10.57% within 6 months after discharge, which was slightly lower than similar studies [15]. Moreover, DM existed as the only independent risk factor for six-month survival in PLA patients after hospitalization in this cohort and other high-risk factors, such as age > 60 years, cirrhosis, diameter of the abscess, and gas-forming were not statistically significant in the multivariate model [15,17]. Compared with 7.83% in PLA patients without DM, the mortality dramatically increased to 18.03% in patients with DM.…”

Section: Discussioncontrasting

confidence: 77%

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Effect of diabetes mellitus on short-term prognosis of 227 pyogenic liver abscess patients after hospitalization

Zhou

Zhao

et al. 2020

BMC Infect Dis

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Background: Pyogenic liver abscess (PLA) is an inflammatory disease with increasing incidence. When it occurs with diabetes mellitus (DM), the risk of recurrence and mortality may increase. However, the effect of DM on the short-term prognosis of PLA patients after hospitalization remained unknown. Methods: Two hundred twenty-seven PLA patients who received treatment at the First were retrospectively enrolled. They were divided into two groups as the DM group (n = 61) and the Non-DM group (n = 166). In the DM group, HbA1C level < 7% was considered to be good-control of glycaemia (n = 23). The clinical characteristics and overall short-term survival were analyzed. Results: The proportion of PLA patients with DM was 26.87%. In the DM group, there was a higher incidence of hypertension and Candida spp. infection. Conservative administration and percutaneous drainage were mainly used in patients with good-(60.87%) and poor-control (60.53%) of glycaemia, respectively. During follow-up, 24 (10.57%) died due to uncontrolled systemic infections and other serious complications. Compared with PLA patients without DM, patients in the DM group had significantly increased 6-month mortality rate after discharge (Log-Rank test, P = 0.021). Poor-control of glycaemia did not reduce the six-month survival, while the recurrence rate of PLA within 3 months showed an almost 3-fold increase (13.16% vs. 4.35%). Further multivariate analyses found that DM was the only independent risk factor for the PLA six-month survival (odds ratio [OR]: 3.019, 95% confidence interval [CI]: 1.138-8.010, P = 0.026). However, the blood glucose level had no significant effect on the short-term survival of PLA patients with DM (Log-Rank test, P = 0.218). Conclusions: In PLA patients, DM aggravated short-term mortality and blood glucose levels should be well controlled.

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Section: Discussioncontrasting

confidence: 77%

“…PLA and DM are high wasting diseases and often progress rapidly when both occur. Meanwhile, the development of the PLA has unique characteristics, and the mortality rate is high during the onset period [15]. Combined with DM in PLA patients should have a significant impact on overall survival, especially in the short onset period.…”

Section: Discussionmentioning

confidence: 99%

Effect of diabetes mellitus on short-term prognosis of 227 pyogenic liver abscess patients after hospitalization

Zhou

Zhao

et al. 2020

BMC Infect Dis

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“…In this study, the six-month follow-up was performed on 227 PLA patients who were retrospectively enrolled. We found that the overall mortality rate was 10.57% within six months after discharge, which was slightly lower than similar studies [15].…”

Section: Discussioncontrasting

confidence: 71%

“…Moreover, DM existed as the only independent risk factor for six-month survival in PLA patients after hospitalization in this cohort and other high-risk factors, such as age > 60 years, cirrhosis, diameter of the abscess, and gas-forming were not statistically significant in the multivariate model [15,17].…”

Section: Discussionmentioning

confidence: 64%

Effect of Diabetes Mellitus on short-term prognosis of 227 pyogenic liver abscess patients after hospitalization

Zhou

Zhao

et al. 2020

Preprint

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Background: Pyogenic liver abscess (PLA) is an inflammatory disease with increasing incidence. When it occurs with diabetes mellitus (DM), risk of recurrence and the mortality may increase. However, the effect of DM on short-term prognosis of PLA patients after hospitalization remained unknown. Methods: 227 PLA patients who received treatment at the First Affiliated Hospital of Xi’an Jiaotong University from January 2011 to January 2018 were retrospectively enrolled. They were divided into two groups as DM group (n=61) and Non-DM group (n=166). In the DM group, HbA1C level <7% was considered to be good-control of glycaemia (n=23). The clinical characteristics and overall short-term survivals were analyzed. Results: The proportion of PLA patients with DM was 26.87%. In the DM group, there was a higher incidence of hypertension and Candida spp. infection. Conservative administration and percutaneous drainage were mainly used in patients with good- (60.87%) and poor-control (60.53%) of glycaemia, respectively. During follow-up, 24 (10.57%) died due to uncontrolled systemic infections and other serious complications. Compared with PLA patients without DM, patients in the DM group had significantly increased 6-month mortality rate after discharge (Log-Rank test, P =0.021). Poor-control of glycaemia did not reduce the six-month survival, while the recurrence rate of PLA within three months showed an almost 3-fold increase (13.16% vs. 4.35%). Further multivariate analyses found that DM was the only independent risk factor for the PLA six-month survival (odd ratio [OR]: 3.019, 95% confidence interval [CI]: 1.138-8.010, P =0.026). However, the blood glucose level had no significant effect on the short-term survival of PLA patients with DM (Log-Rank test, P =0.218). Conclusions: In PLA patients, DM aggravated short-term mortality and blood glucose levels should be well controlled.

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“…This NHSO database is nationwide study, and its coverage of at least of 67.6% of the population of Thailand in 2013 and this database were used and validate in several studies including disease burden of cirrhosis, drug induced liver injury and liver abscess [12–14]. Most of ICC patients presented with advanced stages by their clinical findings and complications.…”

Section: Discussionmentioning

confidence: 99%

A significant cancer burden and high mortality of intrahepatic cholangiocarcinoma in Thailand: a nationwide database study

et al. 2017

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BackgroundWe aimed to examine the burden of intrahepatic cholangiocarcinoma (ICC) in Thailand and identify the prognostic factors for all-causes of death.MethodsWe conducted a population-based study of ICC patients admitted during 2009–2013 using the Nationwide Hospital Admission Database, the National Health Security Office (NHSO). There was an average of 1,051,146 patients/year with diagnosis of gastrointestinal diseases (GI). All patients with a diagnosis of ICC (ICD10- C221) were included from a total of 72,479 admissions from 858 hospitals. The surgical resection procedures such as the radical pancreaticoduodenectomy, subtotal and partial hepatectomy were analyzed. Data for all patients were censored 1 year post-study or death, whichever came first.ResultsA total of 34,325 patients with ICC during a 5-year study period (on average, 6865 patients/year, with the incidence rate of 14.6 per 100,000 population, per year. The ICC patients had a mean age of 63.8+/−11.6 years and 63% were males. The mean length of hospital stay was 6.4+/−7.3 days with a mean+/−SD cost of hospitalization of $595+/−$1160 USD per admission. There were 659 patients (1.9%) underwent surgical resection. The overall survival of ICC patients with surgery was significantly better than those patients without surgery. Hazard ratio of death for patients without surgery was 2.5 (95% CI of 2.3–2.7). Approximately 14% of the ICC patients died during hospitalization. The median overall survival of all patients after the first admission was 53 +/−0.6 days. From the multivariate analysis, factors related to all-causes of death were: patients’ age >60 years (OR = 1.2, 95% CI; 1.1–1.3), length of hospital stay of >7 days (OR = 1.1, 95% CI; 1.02–1.2), male (OR = 1.3, 95% CI; 1.2–1.4), living in the northern part of Thailand (OR = 1.5, 95% CI; 1.3–1.8) and presence of complications during admission (OR = 1.3, 95% CI; 1.1–1.5).ConclusionThe disease burden of patients with ICC in Thailand is significant with the incidence rate of 14.6 per 100,000 population, per year during 2009–2013 and showed high mortality rate of 14%.Electronic supplementary materialThe online version of this article (doi:10.1186/s12876-016-0565-6) contains supplementary material, which is available to authorized users.

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Burden of Liver Abscess and Survival Risk Score in Thailand: A Population-Based Study

Cited by 17 publications

References 24 publications

Effect of diabetes mellitus on short-term prognosis of 227 pyogenic liver abscess patients after hospitalization

Effect of diabetes mellitus on short-term prognosis of 227 pyogenic liver abscess patients after hospitalization

Effect of Diabetes Mellitus on short-term prognosis of 227 pyogenic liver abscess patients after hospitalization

A significant cancer burden and high mortality of intrahepatic cholangiocarcinoma in Thailand: a nationwide database study

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