Burden of Itch in Patients with Basal Cell Carcinoma

Abstract

Basal cell carcinoma is the most common humane cancer, and its incidence is still raising. Here we analyzed the data of 180 patients with basal cell carcinoma regarding the influence of itch on quality of life and psychosocial status of these patients. Patients struggling with this skin cancer had greatly reduced general health perception comparing to the normative population. Moreover, more than 15% of these patients may be threatened with the co-existence of depression. Itch presence and intensity may diminish quality of life among the affected subjects with basal cell carcinoma.The incidence of basal cell carcinoma has increased in recent years. The aim of this study was to analyse the influence of itch on quality of life and psychosocial status of patients with basal cell carcinoma. A total of 180 patients with basal cell carcinoma were included in the study. Itch intensity was assessed with Numerical Rating Scale and 4-Item Itch Questionnaire (4IIQ). Quality of life in basal cell carcinoma was assessed with the 36-item Short-Form Health Survey (SF-36), Dermatology Life Quality Index (DLQI), 6 Item Stigmatization Scale (6-ISS) and Beck Depression Inventory (BDI). Mean DLQI in the study group was 2.0 ± 2.0, while mean SF-36 was 71.38 ± 15.77 points. The intensity of itch assessed with 4IIQ correlated negatively with SF-36 (R = -0.48, p = 0.003). The mean ± SD BDI score was 6.16 ± 5.72 points and mean 6-ISS score was 0.66 ± 1.24. In conclusion, presence and intensity of itch may debilitate quality of life among patients with basal cell carcinoma.

Prevalence, Intensity and Psychosocial Burden of Acne Itch: Two Different Cohorts Study

“…To the best of our knowledge, this is the first study to clearly show that acne itching, even of mild intensity, is positively correlated with QoL impairment. Previous studies by our group showed correlations between itch intensity and QoL assessment in various dermatoses, including psoriasis [ 44 , 45 , 46 ], atopic dermatitis [ 47 ], hidradenitis suppurativa [ 48 ], dermatophytosis [ 49 ], and basal cell carcinoma [ 50 ]. The same correlations were noted between systemic itch and QoL in patients suffering from polycythemia vera [ 51 ], chronic kidney disease [ 52 , 53 ], diabetes [ 54 , 55 ], and even in renal transplant recipients [ 56 ].…”