Burden of Iron Deficiency and Correlation of Reticulocyte Hemoglobin Content (CHr) in Iron Deficiency-a Study from Tertiary Care Center in Developing Country

Chadha, Vaibhav; Mudaliar, Sangeeta; Khurana, Ritika; Shah, Dhara; Dhabale, Trupti; Mamtora, Dhruv; Bodhanwala, Minnie; Desai, Mukesh; Agarwal, Bharat; Rao, Sudha

doi:10.1182/blood-2022-166045

Blood

2022

DOI: 10.1182/blood-2022-166045

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Burden of Iron Deficiency and Correlation of Reticulocyte Hemoglobin Content (CHr) in Iron Deficiency-a Study from Tertiary Care Center in Developing Country

Vaibhav Chadha

Sangeeta Mudaliar

Ritika Khurana

et al.

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2024

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Reference values for reticulocyte haemoglobin equivalent in healthy Chinese children under 5 years and its associations with various blood parameters

Tung,

Chen,

Chiu

et al. 2024

bmjpo

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BackgroundReticulocyte haemoglobin equivalent (RET-He) is a useful tool for evaluating recent iron usage irrespective of inflammatory status. This study aims to establish a reference for RET-He among Hong Kong healthy children under the age of 5 years and to investigate the association between RET-He and various blood parameters.MethodsA total of 946 children aged 2–48 months from July 2019 to December 2022 were recruited in this cross-sectional study. The RET-He and other haematological parameters were measured by the haematology analyser from Sysmex XN-9100/XN-1500. The ferritin test was performed with the electrochemiluminescence immunoassay. Interval 2.5th percentile to 97.5th percentile represented the normal RET-He ranges. Linear multiple regression analysis was performed to examine the relation between RET-He and various blood parameters. Receiver-operating characteristic curve analysis revealed the sensitivity and specificity of RET-He in identifying iron deficiency.ResultsThe RET-He in the study population was approximately normally distributed. The age-specific lower limit of RET-He ranges from 25.81 pg (25–36 months) to 27.15 pg (13–24 months). RET-He was found to be lower in the age group 2–6 months (mean=29.47 pg) and 7–12 months (mean=29.41 pg). Changes in RET-He and haemoglobin in relation to age were observed in both sexes (both p<0.001). RET-He was influenced by age, some red blood cell parameters and reticulocyte concentrations (all p<0.05). A cut-off value of RET-He ≤27.8 pg was determined for identifying iron deficiency.ConclusionsRET-He levels varied with age, with a relatively lower level in infants than in other age groups. The value below the age-specific lower limit of the reference range of RET-He can be used as a limit for preliminary iron-deficiency screening.

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Reference values for reticulocyte haemoglobin equivalent in healthy Chinese children under 5 years and its associations with various blood parameters

Tung,

Chen,

Chiu

et al. 2024

bmjpo

View full text Add to dashboard Cite

show abstract

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Burden of Iron Deficiency and Correlation of Reticulocyte Hemoglobin Content (CHr) in Iron Deficiency-a Study from Tertiary Care Center in Developing Country

Cited by 1 publication

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Reference values for reticulocyte haemoglobin equivalent in healthy Chinese children under 5 years and its associations with various blood parameters

Reference values for reticulocyte haemoglobin equivalent in healthy Chinese children under 5 years and its associations with various blood parameters

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