Burden of HCV infection among pregnant women with assessment of risk factors and pregnancy outcome in HCV infected: A hospital based study from Uttarakhand

Upreti, Purnima

doi:10.18535/jmscr/v5i1.159

Cited by 2 publications

(2 citation statements)

References 26 publications

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“…26 Another study from Uttarakhand, also reported seroprevalence of hepatitis C to be 0.89% among pregnant women. 27 Both these studies corroborate this finding. However, in contrast to this finding, a study from Sangareddy, Telangana state reported very low prevalence (0.21%) of HCV infection among pregnant women.…”

Section: Discussionsupporting

confidence: 67%

Prevalence of hepatitis C among pregnant females attending antenatal clinic at a tertiary care hospital in Lucknow, Uttar Pradesh, India

et al. 2020

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Background: Hepatitis C virus (HCV) is a major causative agent of parenterally acquired hepatitis. Vertical transmission of HCV occurs from mother to infant during pregnancy, delivery, or neonatal period. Hepatitis C infection among pregnant females can adversely affect both mother and fetus, leading to chronic infection in infants who later develop liver cirrhosis and hepatocellular carcinoma. Objective of the study was to evaluate the prevalence of hepatitis C among pregnant females attending antenatal clinic.Methods: A hospital based cross-sectional study was done over a period of six months from January to June 2019. A total of 550 pregnant females were included in the study who attended Antenatal Clinic for routine check-up and whose blood samples were sent to Microbiology Laboratory for screening of anti-HCV antibodies by Enzyme linked Immunosorbent Assay (ELISA) method.Results: Out of 550 pregnant females tested, 3 were found to be reactive to anti-HCV antibodies by ELISA; hence the prevalence was found to be 0.5%. All 3 seropositive females belonged to age group 26-35 years, were indoor patients (IPD) and belonged to lower socio-economic class. Majority of seropositive females belonged to urban areas (66.7%, 2/3) as compared to those from rural areas (33.3%, 1/3).Conclusions: Although, prevalence of hepatitis C was found to be less among pregnant females attending ANC of this institute, still routine screening of all pregnant females for anti-HCV antibodies is highly recommended, for timely detection of disease in mothers and prevention of its transmission to infants.

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Section: Discussionsupporting

confidence: 67%

Prevalence of hepatitis C among pregnant females attending antenatal clinic at a tertiary care hospital in Lucknow, Uttar Pradesh, India

et al. 2020

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“…Among the risk factors studied, previous surgery and blood transfusion were found to be the important risk factors observed in 16 (25.80%) and 5 (8.06%) of anti-HCV positive pregnant women. 19 In another study 39 (0.48%) women were found to be HBsAg carriers. Furthermore, prevalence was much lower in German-born women (0.2%) in comparison to Asian-born women (9.1%) and these women with HBsAg had no significantly increased prevalence of adverse pregnancy outcomes.…”

Section: Discussionmentioning

confidence: 91%

A prospective study of demographic profile, risk factors and pregnancy outcome in Hepatitis B and Hepatitis C virus positive pregnant women in a tertiary care centre

Sharma¹,

Agarwal²,

Bajpai³

et al. 2020

Int J Reprod Contracept Obstet Gynecol

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Background: Viral hepatitis is the most common liver disease in pregnancy and is also the most common cause of jaundice in pregnancy in tropical countries. Risk factors for transmission are intravenous drug abuse, surgical and dental procedures done without adequate sterilization of instruments, sexual route etc. Early diagnosis and management can prevent maternal and fetal complications. This study was done to evaluate the frequency, risk factors and pregnancy outcome in hepatitis B virus (HBV) and hepatitis C virus (HCV) positive antenatal women.Methods: This case control study was conducted in Teerthankar Mahaveer Medical College and Research Centre, Moradabad, Uttar Pradesh, India from January 2017 to June 2018 on total 2511 pregnant women. The serum samples were checked for presence of hepatitis B surface antigen (HBsAg) and presence of IgG antibodies to HCV. Analysis of sociodemographic profile, risk factors and pregnancy outcome were done in all HBV and HCV positive women.Results: Out of 2511 pregnant women, 292 were tested positive for hepatitis. Maximum number of women were in the age group of 21-30 years. Most of the seropositive women were multipara. Frequency of positivity was maximum for HCV (67.1%). The risk factors for transmission in study population were intravenous drug abuse, blood transfusion, history of surgery and tattooing.Conclusions: Hepatitis infection rate is increasing. Universal screening for HBV and HCV can be recommended in pregnant women in developing countries. Education and awareness of public and health care workers can reduce the risk of transmission.

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Burden of HCV infection among pregnant women with assessment of risk factors and pregnancy outcome in HCV infected: A hospital based study from Uttarakhand

Abstract: Introduction: Hepatitis-C is a global health problem. Risk factors for HCV infection include intravenous drug use, transfusion of infected blood or blood products, unsafe therapeutic injections and surgical

Cited by 2 publications

References 26 publications

Prevalence of hepatitis C among pregnant females attending antenatal clinic at a tertiary care hospital in Lucknow, Uttar Pradesh, India

Prevalence of hepatitis C among pregnant females attending antenatal clinic at a tertiary care hospital in Lucknow, Uttar Pradesh, India

A prospective study of demographic profile, risk factors and pregnancy outcome in Hepatitis B and Hepatitis C virus positive pregnant women in a tertiary care centre

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