Burden of H1N1 Influenza Related Mortality in a Tertiary Care Centre

Bhat, Supriya Prathibha Shankaranarayana; Bhat, Mahalingeshwara Kelagina Pidamale; Kumar, Ruhi; Hosmane, Giridhar Belur; D’sa, Ivor Peter

doi:10.14260/jemds/2020/858

Cited by 1 publication

(1 citation statement)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Pandemic H1N1 influenza (pH1N1), a severe acute respiratory illness (SARI) caused by influenza A(H1N1)pdm09, contributed to increased mortality among those infected with different influenza A subtype viruses [ 1 ]. In India, Maharashtra, a state in the western part of the country, accounts for 21% of all the influenza A(H1N1)pdm09 cases and 31% of all pH1N1-related deaths [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

TNFA and IL10 Polymorphisms and IL-6 and IL-10 Levels Influence Disease Severity in Influenza A(H1N1)pdm09 Virus Infected Patients

Alagarasu

Kaushal

Shinde

et al. 2021

Genes

View full text Add to dashboard Cite

Cytokines are key modulators of immune response, and dysregulated production of proinflammatory and anti-inflammatory cytokines contributes to the pathogenesis of influenza A(H1N1)pdm09 virus infection. Cytokine production is impacted by single nucleotide polymorphisms (SNPs) in the genes coding for them. In the present study, SNPs in the IL6, TNFA, IFNG, IL17A, IL10, and TGFB were investigated for their association with disease severity and fatality in influenza A(H1N1)pdm09-affected patients with mild disease (n = 293) and severe disease (n = 86). Among those with severe disease, 41 patients had fatal outcomes. In a subset of the patients, levels of IL-2, IL-4, IL-6, IL-10, TNF, IFN-γ, and IL-17 were assayed in the plasma for their association with severe disease. The frequency of TNFA rs1800629 G/A allele was significantly higher in severe cases and survived severe cases group compared to that of those with mild infection (OR with 95% for mild vs. severe cases 2.95 (1.52–5.73); mild vs. survived severe cases 4.02 (1.84–8.82)). IL10 rs1800896-rs1800872 G-C haplotype was significantly lower (OR with 95% 0.34 (0.12–0.95)), while IL10 rs1800896-rs1800872 G-A haplotype was significantly higher (OR with 95% 12.11 (2.23–76.96)) in fatal cases group compared to that of the mild group. IL-6 and IL-10 levels were significantly higher in fatal cases compared to that of survived severe cases. IL-6 levels had greater discriminatory power than IL-10 to predict progression to fatal outcome in influenza A(H1N1)pdm09 virus-infected patients. To conclude, the present study reports the association of TNFA and IL10 SNPs with severe disease in Influenza A(H1N1)pdm09 virus-infected subjects. Furthermore, IL-6 levels can be a potential biomarker for predicting fatal outcomes in Influenza A(H1N1)pdm09 virus infected subjects.

show abstract

Section: Introductionmentioning

confidence: 99%