Burden of disease from breast cancer attributable to smoking and second‐hand smoke exposure in Europe

Carreras, Giulia; Lachi, Alessio; Boffi, Roberto; Clancy, Luke; Gallus, Silvano; Fernández, Esteve; López, María José; Soriano, Joan B.; Nicolás, Ángel López; Semple, Sean; Behrakis, Panagiotis; Gorini, Giuseppe

doi:10.1002/ijc.33021

Cited by 17 publications

(10 citation statements)

References 14 publications

(16 reference statements)

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“…Although BC is not initially thought to be a tobacco-related cancer, over the past few decades, many chemicals contained in tobacco have been investigated to be a trigger of BC, such as 4-aminobiphenyl ( 19 , 20 ) and benzopyrene ( 21 , 22 ). In addition, evidence of the role of active smoking ( 23 , 24 ) and secondhand smoke ( 25 , 26 ) in the etiology of BC is accumulating, based on adequate animal trials ( 27 , 28 ) and relevant epidemiological evidence ( 29 ). Recent trends have discovered smoking as one of the potential risk factors for BC ( 30 ).…”

Section: Introductionmentioning

confidence: 99%

The relationship between tobacco and breast cancer incidence: A systematic review and meta-analysis of observational studies

et al. 2022

Front. Oncol.

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BackgroundThe effect of tobacco on breast cancer (BC) is controversial. The purpose of this study was to investigate the relationship between tobacco and BC.MethodsA search was conducted in PubMed, EBSCO, Web of Science and Cochrane Library databases before February 2022. The adjusted odd ratio (OR) and corresponding 95% confidence interval (CI) were used to examine the relationship between active or passive smoking and BC risk.ResultsA total of 77 articles composed of 2,326,987 participants were included for this meta-analysis. Active (OR=1.15, 95% CI=1.11-1.20, p<0.001) and passive (OR=1.17, 95% CI=1.09-1.24, p<0.001) smoking increased the risk of BC in the female population, especially premenopausal BC (active smoking: OR=1.24, p<0.001; passive smoking: OR=1.29, p<0.001), but had no effect on postmenopausal BC (active smoking: OR=1.03, p=0.314; passive smoking: OR=1.13, p=0.218). Active smoking increased the risk of estrogen receptor-positive (ER+) BC risk (OR=1.13, p<0.001), but had no effect on estrogen receptor-negative (ER-) BC (OR=1.08, p=0.155). The risk of BC was positively associated with the duration and intensity of smoking, negatively associated with the duration of smoking cessation. Active smoking increased the risk of BC in the multiparous population (OR=1.13, p<0.001), but had no effect on the nulliparous population (OR=1.05, p=0.432), and smoking before the first birth (OR=1.22, 95% CI=1.17-1.27) had a greater impact on the risk of BC than smoking after the first birth (OR=1.08, 95% CI=1.04-1.12).ConclusionSmoking (active and passive) increased the risk of BC in women. The effect of smoking on BC was influenced by smoking-related factors (duration, intensity, years of quitting), population-related factors (fertility status), and BC subtypes.Systematic Review Registrationidentifier CRD42022322699.

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Section: Introductionmentioning

confidence: 99%

The relationship between tobacco and breast cancer incidence: A systematic review and meta-analysis of observational studies

et al. 2022

Front. Oncol.

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“…The majority of women, particularly those in rural areas, remain unaware of the detrimental health effects of passive smoking. Secondhand smoke has been associated with female sexual dysfunction, cervical carcinoma, breast cancer, and other gynecological diseases [ 6 , 7 , 8 ]. For pregnant women, passive smoking is a risk factor for adverse birth outcomes [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Association of Rare Earth Elements with Passive Smoking among Housewives in Shanxi Province, China

Chen

et al. 2022

IJERPH

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Background: Rare earth elements (REEs) are emerging contaminants. Previous studies reported the association between REEs and active smoking, but little is known about the effects of passive smoking on this condition. In China, female passive smoking is widespread, particularly in rural areas. Objective: This study aimed to estimate the relationship between REEs accumulation and passive smoking among rural housewives. Methods: We recruited 385 subjects in Shanxi Province of northern China, of whom 117 housewives were exposed to passive smoking, and 268 were not. We analyzed 15 REEs in the hair of housewives with ICP–MS, including lanthanum, cerium, praseodymium, neodymium, samarium, europium, gadolinium, terbium, dysprosium, holmium, erbium, thulium, ytterbium, lutetium, and yttrium. Results: The results indicated higher levels of 14 REEs except for Sm in both the univariate and adjusted models among the housewives exposed to passive smoking. The increasing linear trend of adjusted odds ratios of 15 REEs supported their association. The Bayesian kernel machine regression (BKMR) models showed that 15 REEs had a significant overall effect, and Eu had a single-exposure effect with passive smoking. Conclusion: We concluded that passive smoking might be associated with increased exposure to REEs among rural housewives.

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“…There is a documented increased risk of breast cancer in patients who smoke at least five cigarettes a day or greater than 10 packs per year (a total of 21% increase in breast cancer) [ 7 , 8 ]. This phenomenon can be attributed to the high levels of carcinogens in tobacco contained within a cigarette [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

Smoking and Fibrocystic Changes in the Breast: A Case Report of a Lifelong Smoker and Changes in Breast Parenchyma

Bhatti¹,

Bokhari²,

Khan³

2022

Cureus

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Smoking is a well-known risk factor for breast cancer, and the nicotine in cigarette smoke has been associated with fibrotic changes in the breast. Although considered benign, these changes have the potential to make surgical dissection more difficult and may increase the risk of surgical complications. Here we discuss the case of a middle-aged female who was a lifelong smoker with breast cancer and who underwent a simple mastectomy. Intra-operatively, the overall breast parenchyma appeared quite firm, making tissue dissection challenging and the operating surgeon had to endure to remove the tumor and the remaining breast tissue.

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Burden of disease from breast cancer attributable to smoking and second‐hand smoke exposure in Europe

Cited by 17 publications

References 14 publications

The relationship between tobacco and breast cancer incidence: A systematic review and meta-analysis of observational studies

The relationship between tobacco and breast cancer incidence: A systematic review and meta-analysis of observational studies

Association of Rare Earth Elements with Passive Smoking among Housewives in Shanxi Province, China

Smoking and Fibrocystic Changes in the Breast: A Case Report of a Lifelong Smoker and Changes in Breast Parenchyma

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