Burden of disease and patient-reported outcomes in patients with moderate to severe ulcerative colitis in the last 12 months – Multicenter European cohort study

Assche, Gert Van; Peyrin–Biroulet, Laurent; Sturm, Andreas; Gisbert, Javier P.; Gaya, Daniel R.; Bokemeyer, B.; Mantzaris, Gerassimos J.; Armuzzi, Alessandro; Sebastian, Shaji; Lara, Núria; Lynam, M. Judith; Rojas-Farreras, S.; Fan, Tao; Ding, Qian; Black, Chris; Kachroo, Sumesh

doi:10.1016/j.dld.2016.01.011

Cited by 44 publications

(38 citation statements)

References 30 publications

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“…The HRQoL as measured with SIBDQ compares to international studies [25][26][27] . Furthermore, a number of studies show that QoL is related to disease activity in patients with UC [28][29][30][31] .…”

Section: Discussionmentioning

confidence: 99%

Quality of life and patient preferences among Danish patients with ulcerative colitis – results from a survey study

Hagelund¹,

Stallknecht²,

Jensen³

2020

Current Medical Research and Opinion

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Objective: To explore health-related quality of life (HRQoL) and assess preferences for medical treatment attributes to obtain information of the relative importance of the different attributes in a Danish population with ulcerative colitis (UC). Methods: We used data from an online survey collected in March 2018 among people with selfreported UC. A total of 302 eligible respondents answered the HRQoL questionnaires (EuroQol-5 Dimensions (EQ-5D-5L) and the Short Inflammatory Bowel Disease Questionnaire (SIBDQ)), and 212 also completed the discrete choice experiment (DCE). The probability of choosing an alternative from a number of choices in the DCE was estimated using a conditional logit model. Results: The respondents had an average SIBDQ score of 4.5 and an HRQoL score of 0.77, applying the EQ-5D-5L questionnaire. HRQoL correlated with disease severity, and the respondents had lower HRQoL than did a gender-and age-matched subset of the Danish population. The most important medical treatment attribute was efficacy within eight weeks. Additionally, respondents stated a preference for avoiding taking steroids, for fast onset of effect and for oral formulations. Conclusions: HRQoL correlates with disease severity, and patients with UC have lower HRQoL than the general population. The most important treatment attribute was efficacy, but patients also would like to avoid steroids, value fast onset of effect and prefer oral formulations. ARTICLE HISTORY

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Section: Discussionmentioning

confidence: 99%

Quality of life and patient preferences among Danish patients with ulcerative colitis – results from a survey study

Hagelund¹,

Stallknecht²,

Jensen³

2020

Current Medical Research and Opinion

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“…The correlation between patient‐reported outcomes is generally high but associated factors should be compared and evaluated in future studies . Several studies have investigated different kinds of patient‐reported outcomes (eg IBDQ, SF36 and FACIT‐F) and factors associated with worse outcomes (eg female gender, smoking and disease activity) . Thus, factors found in this review to be associated with high disability are comparable, although medical treatment (eg biological therapy) and smoking were not associated with worse disability.…”

Section: Discussionmentioning

confidence: 99%

Systematic review and meta‐analysis: assessment of factors affecting disability in inflammatory bowel disease and the reliability of the inflammatory bowel disease disability index

Prosberg

Gluud

et al. 2017

Aliment Pharmacol Ther

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“…The treatment and control of UC is met with varying degrees of success, and therapeutic decision making is usually symptomatology-led. It is increasingly the case, however, that patients are becoming more involved in the management of their disease [89]. In fact, 98% of patients in a study exploring patient empowerment considered active involvement in decision making to be quite or very important [90].…”

Section: Doi: 101159/000496739mentioning

confidence: 99%

Unmet Medical Needs in Ulcerative Colitis: An Expert Group Consensus

Danese

Allez

Bodegraven

et al. 2019

Dig Dis

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Background: The authors aimed to conduct an extensive literature review and consensus meeting to identify unmet needs in ulcerative colitis (UC) and ways to overcome them. UC is a relapsing and remitting inflammatory bowel disease with varied, and changing, incidence rates worldwide. UC has an unpredictable disease course and is associated with a high health economic burden. During 2016 and 2017, a panel of experts was convened to identify, discuss and address areas of unmet need in UC. Methods: PubMed and Cochrane Library databases were searched for relevant articles describing studies performed in patients with UC. These findings were used to generate a set of statements relating to unmet needs in UC. Consensus on these statements was then sought from a panel of 9 expert gastroenterologists using a modified Delphi review process that consisted of anonymous surveys followed by live meetings. Results: In 2 literature reviews, over 5,000 unique records were identified and a total of 138 articles were fully reviewed. These were used to consider 26 areas of unmet need, which were explored in 2 face-to-face meetings, in which the statements were debated and amended, resulting in consensus on 30 final statements. The unmet needs identified were categorised into 7 areas: impact of UC on patients’ daily life; importance of early diagnosis and treatment; drawbacks of existing treatments; urgent need for new treatments; and disease-, practice- or patient-focused unmet needs. Conclusions: These expert group meetings found a number of areas of unmet needs in UC, which is an important first step in tackling them in the future. Future research and development should be focused in these areas for the management of patients with UC.

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Burden of disease and patient-reported outcomes in patients with moderate to severe ulcerative colitis in the last 12 months – Multicenter European cohort study

Cited by 44 publications

References 30 publications

Quality of life and patient preferences among Danish patients with ulcerative colitis – results from a survey study

Quality of life and patient preferences among Danish patients with ulcerative colitis – results from a survey study

Systematic review and meta‐analysis: assessment of factors affecting disability in inflammatory bowel disease and the reliability of the inflammatory bowel disease disability index

Unmet Medical Needs in Ulcerative Colitis: An Expert Group Consensus

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