Burden of cancer attributable to air pollution in Japan in 2015

Abstract

PM 2.5 is a major environmental health problem and a risk factor for lung cancer. Exposure to PM 2.5 has attracted growing public concern nationwide. Here, we aimed to estimate the cancer in 2015 attributable to PM 2.5 in Japan. Ambient air pollution level due to excess concentration of PM 2.5 was estimated using geophysically based satellite-derived PM 2.5 concentrations in 2005, with a spatial resolution of 0.5° × 0.5° longitude-latitude, and population data presented in a 1 km by 1 km grid. We used the WHO guideline value for PM 2.5 exposure (≤ 10 μg/m 3 ) as the optimal level of PM 2.5 exposure. By using relative risk from a large-scale cohort study in Japan, we estimated the population attributable fraction (PAF) for lung cancer, which is positively associated with PM 2.5 , and aggregated the results to obtain the PAF among total cancer incidence and mortality. Population-weighted mean PM 2.5 level in 2005 was 14.9 μg/m 3 . Approximately 95.7% of the population was exposed to levels above the WHO guideline value. Lung cancer attributable to PM 2.5 exposure corresponded to 11,922 cases and 7,264 deaths, which accounted for 9.7% and 9.8% of total lung cancer incidence and mortality, respectively, and 1.2% and 2.0% of total cancer incidence and mortality, respectively. Substantial geographic variation in PM 2.5 -attributable incidence and mortality fractions was found, with cities in western Japan and metropolitan areas having a higher PAF than other municipalities. This study provides useful information to aid policy-makers and public health agencies in the efficient establishment of environmental cancer prevention policies.

Economic burden of cancer attributable to modifiable risk factors in Japan

“…The most up-to-date data on population attributable fraction (PAF) of cancer due to lifestyle and environmental risk factors in Japan is for 2015 (8), namely tobacco smoking (both active and passive) (17), alcohol drinking (18) (20), dietary intake (highly salted food (21), fruit, vegetables, dietary fiber (22), red and processed meat (23)), exogenous hormone use (24), never breastfeeding (25) and air pollution (26). All of the aforementioned factors are considered potentially modifiable via environmental policy, lifestyle change, population-based screening or through vaccination programs.…”