Burden of atrial fibrillation in patients with rheumatic diseases

Khan, Muhammad Zubair; Patel, Kirtenkumar; Patel, Krunalkumar; Doshi, Rajkumar; Shah, Vraj P.; Adalja, Devina; Waqar, Zainulabedin; Franklin, Sona; Gupta, Neelesh; Gul, Muhammad; Jesani, Shruti; Kutalek, Steven P.; Figueredo, Vincent M.

doi:10.12998/wjcc.v9.i14.3252

Cited by 9 publications

(11 citation statements)

References 24 publications

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“…Each admission contains information on patient characteristics including demographics, comorbidities, complications, and primary and secondary discharge diagnoses. This has been explained in detail in previous studies [ 3 , 4 ]. The International Classification of Disease, 9th revision, Clinical Modification (ICD 9-CM) codes were used to identify diagnosis in the NIS database [ 5 , 6 ].…”

Section: Methodsmentioning

confidence: 77%

Clinical In-Hospital Outcomes of Acute Myocardial Infarction in Patients With Hematological Malignancies

Khan¹,

Baqi²,

Patel³

et al. 2022

Cureus

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The purpose of our study is to determine in-hospital outcomes of acute myocardial infarction in patients with hematological malignancies and their subtypes. MethodPatient data were obtained from the nationwide inpatient sample (NIS) database between the years 2009-2014. Patients with hematological cancer subtypes and acute MI (non-ST segment elevation myocardial infarction and ST-segment elevation myocardial infarction (NSTEMI/STEMI) were identified using validated international classification of diseases (ninth revision) and clinical modification (ICD-9-CM) codes. Statistical analysis using the chi-square test was performed to determine the hospital outcomes of acute MI in patients with hematological cancers and subtypes. ResultsThe prevalence of acute myocardial infarction was 2.4% in patients with hematological neoplasms (N=3,027,800). Amongst the subtypes of blood cancers, the highest prevalence of acute MI was seen in lymphocytic leukemia (2.9%). The mortality of MI in patients with hematological malignancies was 16.8% vs 8.8% in patients with non-hematological malignancies, in-hospital costs were $25469 ± 36763 vs. $20534 ± 24767, and length of in-hospital stay was 8.3 ± 10 vs 6.3 ± 7.8 days. Amongst the hematological cancer subtypes, the highest mortality of acute MI was found in myeloid leukemia (23%) followed by multiple myeloma (MM) (17.9%), lymphocytic leukemia (15.9%), and lymphoma (14.4%). The length of stay and hospitalization cost was highest for myeloid leukemia, followed by MM, lymphocytic leukemia, and lymphoma. ConclusionThis study showed that acute MI in patients with hematological malignancies has higher in-hospital mortality, length of stay, and cost. Amongst the blood neoplasm subtypes the highest mortality, length of hospital stay, and hospitalization cost were found in myeloid leukemia.

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Section: Methodsmentioning

confidence: 77%

Clinical In-Hospital Outcomes of Acute Myocardial Infarction in Patients With Hematological Malignancies

Khan¹,

Baqi²,

Patel³

et al. 2022

Cureus

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“…Both AF and gout have similar risk factors. According to the literature, the prevalence of AF in patients with gout is Frontiers in Pharmacology frontiersin.org higher than in those without, although the mechanisms of both conditions remain unclear (Kim et al, 2016;Singh and Cleveland, 2018;Khan et al, 2021). Although the pathogenesis of AF remains only partially understood, the current evidence links AF to inflammation and autonomic nervous system complications.…”

Section: Mechanism Of Atrial Fibrillation Development In Patients Wit...mentioning

confidence: 99%

“…The prevalence of gout in Taiwan is higher than in other countries such as the United Kingdom (2.49%) and the United States (3.9%) ( Kuo et al, 2015 ). Gout results from uric acid deposition; the uric acid links not only to acute or chronic arthritis but also cardiovascular disease ( Kim et al, 2016 ; Singh and Cleveland, 2018 ; Dehlin et al, 2020 ; Khan et al, 2021 ). Past studies demonstrated that the prevalence of atrial fibrillation (AF) and cardiovascular mortality is higher in patients with gout than in those without ( Kim et al, 2016 ; Singh and Cleveland, 2018 ; Khan et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

“…Various factors are related to the incidence of AF, such as hypertension, diabetes, valvular heart disease, and cardiomyopathy ( Staerk et al, 2018 ). Several studies have reported a strong association between AF and gout ( Kuo et al, 2016a ; Singh and Cleveland, 2018 ; Khan et al, 2021 ). In patients with gout, the risk of AF is considerably higher than in those without ( Singh and Cleveland, 2018 ; Khan et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

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Influenza vaccination and risk of atrial fibrillation in patients with gout: A nationwide population-based cohort study

Chen

Chiu

Chen³

et al. 2022

Front. Pharmacol.

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Objective: Although influenza vaccination reduces the risk of atrial fibrillation (AF), its protective effect in patients with gout remains unclear. The present study aimed to evaluate the protective effect of influenza vaccination in patients with gout.Methods: A total of 26,243 patients with gout, aged 55 and older, were enrolled from the National Health Insurance Research Database (NHIRD) between 1 January 2001, and 31 December 2012. The patients were divided into vaccinated (n = 13,201) and unvaccinated groups (n = 13,042). After adjusting comorbidities, medications, sociodemographic characteristics, the risk of AF during follow-up period was analyzed.Results: In influenza, non-influenza seasons and all seasons, the risk of AF was significantly lower in vaccinated than in unvaccinated patients (Adjust hazard ratio [aHR]: 0.59, 95% confidence interval [CI]: 0.50–0.68; aHR: 0.50, 95% CI: 0.42–0.63; aHR: 0.55, 95% CI: 0.49–0.62, respectively). In addition, the risk of AF significantly decreased with increased influenza vaccination (aHR: 0.85, 95% CI: 0.69–1.04; aHR: 0.72, 95% CI: 0.60–0.87; aHR: 0.40, 95% CI: 0.33–0.49, after first, 2–3 times, and ≥4 times of vaccination, respectively). Furthermore, sensitivity analysis indicated that the risk of AF significantly decreased after influenza vaccination for patients with different sexes, medication histories, and comorbidities.Conclusions: Influenza vaccination is associated with a lower risk of AF in patients with gout. This potentially protective effect seems to depend on the dose administered.

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“…We relied on diagnosis codes for cancer subtypes and AF, which could potentially lead to exposure and outcome misclassification, however, both ICD codes for AF and cancers are validated and used in several studies. 23 , 24 We did not investigate the severity and stages of cancers which could affect the development of AF. In addition, we did not study the effect of chemotherapy on the development of AF.…”

Section: Limitationmentioning

confidence: 99%

Association of atrial fibrillation and various cancer subtypes

Khan

Gupta

Patel

et al. 2021

Journal of Arrhythmia

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Background Studies have shown that the incidence of atrial fibrillation (AF) in cancer is most likely due to the presence of inflammatory markers. The purpose of our study is to determine the association of AF with different cancer subtypes and its impact on in‐hospital outcomes. Methods Data were obtained from the National Inpatient Sample database between 2005 and 2015. Patients with various cancers and AF were studied. ICD‐9‐CM codes were utilized to verify variables. Patients were divided into three age groups: Group 1 (age < 65 years), Group 2 (age 65‐80 years), and Group 3 (age > 80 years). Statistical analysis was performed using Pearson chi‐square and binary logistic regression analysis to determine the association of individual cancers with AF. Results The prevalence of AF was 14.6% among total study patients (n = 46 030 380). After adjusting for confounding variables through multivariate regression analysis, AF showed significant association in Group 1 with lung cancer (odds ratio, OR = 1.92), multiple myeloma (OR = 1.59), non‐Hodgkin lymphoma (OR = 1.55), respiratory cancer (OR = 1.55), prostate cancer (OR = 1.20), leukemia (OR = 1.12), and Hodgkin's lymphoma (OR = 1.03). In Group 2, the association of AF with multiple myeloma (1.21), lung cancer (OR = 1.15), Hodgkin lymphoma (OR = 1.15), non‐Hodgkin lymphoma (OR = 1.12), respiratory cancer (OR = 1.08), prostate cancer (OR = 1.06), leukemia (OR = 1.14), and colon cancer (OR = 1.01) were significant. In Group 3, AF showed significant association with non‐Hodgkin lymphoma (OR = 1.06), prostate (OR = 1.03), leukemia (OR = 1.03), Hodgkin's lymphoma (OR = 1.02), multiple myeloma (OR = 1.01), colon cancer (OR = 1.01), and breast cancer (OR = 1.01). The highest mortality was found in lung cancer in age <80 and prostate cancer in age >80. Conclusion In patients age <80 years, AF has significant association with lung cancer and multiple myeloma, whereas in patients age >80 years, it has significant association with non‐Hodgkin lymphoma and prostate cancer. In patients age <80 years, increased mortality was seen in AF with lung cancer and in patients age >80 years, increased mortality was seen in those with AF and prostate cancer. Twitter Abstract In age <80, lung cancer and multiple myeloma have a strong association with AF while thyroid and pancreatic cancers have no association with AF at any age. In age greater than 80, NHL and prostate cancer have a significant association with AF.

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Burden of atrial fibrillation in patients with rheumatic diseases

Cited by 9 publications

References 24 publications

Clinical In-Hospital Outcomes of Acute Myocardial Infarction in Patients With Hematological Malignancies

Clinical In-Hospital Outcomes of Acute Myocardial Infarction in Patients With Hematological Malignancies

Influenza vaccination and risk of atrial fibrillation in patients with gout: A nationwide population-based cohort study

Association of atrial fibrillation and various cancer subtypes

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