2017
DOI: 10.1186/s12879-017-2317-9
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Burden and spectrum of bacterial infections among sickle cell disease children living in Cameroon

Abstract: BackgroundAlthough sickle cell disease (SCD) children are highly susceptible to bacterial infections (BIs), there is a dreadful lack of data related to the burden and spectrum of BIs in sub-Saharan Africa (SSA), the highest affected region with SCD. This study aimed to determine the burden and spectrum of BIs among SCD children hospitalized in a pediatric reference hospital in Cameroon, a SSA country.MethodsWe conducted a retrospective analysis of records of children hospitalized from November 2012 to August 2… Show more

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Cited by 30 publications
(31 citation statements)
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“…In this study the incidence of VOC was 30% and it was significantly lower with positive microbial infection (p-value0.016); these findings was lower than the (83.3%) reported in a similar study conducted to detect Burden and spectrum of bacterial infections among sickle cell disease children living in Cameroon [27].…”
Section: Discussion:-contrasting
confidence: 73%
See 1 more Smart Citation
“…In this study the incidence of VOC was 30% and it was significantly lower with positive microbial infection (p-value0.016); these findings was lower than the (83.3%) reported in a similar study conducted to detect Burden and spectrum of bacterial infections among sickle cell disease children living in Cameroon [27].…”
Section: Discussion:-contrasting
confidence: 73%
“…A dose of 62.5 mg twice daily is used for infants less than 1 year, 125 mg twice daily for those aged 1-5 years, and 250 mg twice daily in those aged above 5 years [26]. [27].Immunizations in children with SCD should include all regular vaccines, with the addition of the flu vaccine yearly after six months of age; pneumococcal vaccine at two and five years of age; and, possibly, meningococcal vaccine [28].…”
Section: Discussion:-mentioning
confidence: 99%
“…In this, the incidence of VOC was 30% and it was significantly lower with positive microbial infection (p-value0.016); these findings were lower than a similar study (83.3%) conducted to detect Burden and spectrum of bacterial infections among sickle cell disease children living in Cameroon [27].…”
Section: Data Collectioncontrasting
confidence: 68%
“…The pattern of bacterial species isolated from blood of SCD children in this study is also similar to results of the retrospective analysis carried out by Yanda et al . 24 in Cameroon. However, the predominance of Klebsiella sp., S. aureus, and Salmonella sp.…”
Section: Discussionmentioning
confidence: 99%
“…Least susceptibility (21.5%) of isolates from SCD patients to co-trimoxazole was earlier reported by. 24 …”
Section: Discussionmentioning
confidence: 99%