Burden, access and disparities in kidney disease

Abstract

Kidney disease is a global public health problem, affecting over 750 million persons worldwide. The burden of kidney disease varies substantially across the world. In many settings, rates of kidney disease and the provision of its care are defined by socio‐economic, cultural and political factors leading to significant disparities. World Kidney Day 2019 offers an opportunity to raise awareness of kidney disease and highlight disparities in its burden and current state of global capacity for prevention and management. Here we highlight the need for strengthening basic infrastructure for kidney care services for early detection and management of acute kidney injury and chronic kidney disease across all countries and advocate for more pragmatic approaches to providing renal replacement therapies. Achieving universal health coverage worldwide by 2030 is a World Health Organization Sustainable Development Goal. While universal health coverage may not include all elements of kidney care in all countries, understanding what is locally feasible and important with a focus on reducing the burden and consequences of kidney disease would be an important step towards achieving kidney health equity.

Role of Nanotechnology and Their Perspectives in the Treatment of Kidney Diseases

“…More factors, such as high complement component concentrations, pH changes, and disruption or vulnerability of the glycocalyx lining, may increase the susceptibility of the kidney to complement-induced injury (Thurman, 2015). On the other hand, complement-mediated kidney diseases are caused by a wide range of pathogenic mechanisms (Crews et al, 2019). Nanoparticles are currently being used by researchers to develop novel therapeutic medications that can reduce side effects while increasing efficacy.…”

“…Kidney disease is a global issue that affects about 750 million people worldwide, with the severity of the condition varying greatly. The rate of kidney disease and the availability of care for it are largely determined by social, cultural, and political variables, all of which contribute to a major imbalance ( Crews et al, 2019 ). Furthermore, guidelines have been recommended that kidney disease could be recognized as a life-threatening disorder that affects people who require nephrologist’s care, as well as a common disorder with varying severity that requires a concerted public health approach for prevention, early detection, and management ( Rettig et al, 2008 ; Levey and Coresh, 2012 ).…”