Bupropion-Induced Serum Sickness–Like Reaction

McCollom, Robert A.; Elbe, Dean; Ritchie, Alec H

doi:10.1345/aph.19297

Cited by 55 publications

(16 citation statements)

References 5 publications

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“…Bu yayınlarda oluşan yan etkilerin ilaç kesiminden kısa bir süre sonra iyileş-tiğinden söz ediliyordu. [10][11][12][13] Serum hastalığı benzeri reaksiyon, Tip 3 immün kompleks reaksiyonudur. Klinik olarak; ürtiker, eklem ağrısı ve ateş ile tanımlanmaktadır.…”

Section: Discussionunclassified

“…Artrit %10-50 oranında genellikle simetrik olarak müköz membranları tutmaksızın, metakarpofalengeal ve diz eklemlerinde görülür. [11,12] McCollom ve arkadaşlarının yayınladıkları 3 olgu sunumunda ilaç kullanımını takip eden 2-3 hafta içinde başlayan ciltte kaşıntılı lezyonlar, eklem ağrısı ve dilde şişlik şikayetlerinden söz ediliyordu. [12] Ödem, özellikle yüzde ve boyunda oluşur.…”

Section: Discussionunclassified

“…[11,12] McCollom ve arkadaşlarının yayınladıkları 3 olgu sunumunda ilaç kullanımını takip eden 2-3 hafta içinde başlayan ciltte kaşıntılı lezyonlar, eklem ağrısı ve dilde şişlik şikayetlerinden söz ediliyordu. [12] Ödem, özellikle yüzde ve boyunda oluşur. Proteinüri, mikroskopik hematüri ve oligüri gibi böbrek belirtileri oluşabilmesine karşın genellikle ciddi seyirli değildir.…”

Section: Discussionunclassified

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Serum Sickness-Like reaction developed due to Bupropion Hcl during smoking cessation therapy: Case Report

Karademirci¹,

Kutlu²,

Denizhan³

2017

tahd

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Section: Discussionunclassified

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Serum Sickness-Like reaction developed due to Bupropion Hcl during smoking cessation therapy: Case Report

Karademirci¹,

Kutlu²,

Denizhan³

2017

tahd

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“…Serious adverse effects are rare and include seizures and hypersensitivity reactions. The latter can manifest with a variety of eruptions and as a semi-delayed (type III) reaction (4)(5)(6)(7)(8). Bupropion SR is contraindicated in patients with a current seizure disorder or history of seizures.…”

Section: Discussionmentioning

confidence: 99%

Bupropion Hydrochloride Induced Serum Sickness-Like Reaction

Çefle

Yazıcı

2006

ELECTRON J GEN MED

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Sustained-release bupropion is commonly used for the symptomatic relief of depressive disorders and as an adjuvant in smoking cessation therapy. The frequency of adverse reactions with bupropion has been estimated to be more than 1%. Hypersensitivity reactions to bupropion are fairly common and include rare cases of serum sickness-like reaction. Here we report a case of bupropion hydrochloride induced serum sickness-like reaction. Complete resolution of symptoms was achieved on discontinuing bupropion and instituting therapy with glucocorticoid and a non-steroidal antiinflammatory drug.We report this case to notify clinicians of potential serious multisystem complications that can occur with sustained-release bupropion therapy.

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“…Since the risk of seizure appears to be related to dose as well as to the peak plasma concentrations of bupropion, the SR and XL formulations are thought to be associated with a somewhat lower seizure risk, estimated at 0.1% for daily doses lower than 450 mg (Dunner et al, 1998). There are also several reports of bupropion-related hypersensitivity reactions (Bagshaw et al, 2003;Benson, 2001;Chiaverini et al, 2003;Conners et al, 1996;Davis et al, 2001;De Santiago Hernando et al, 2002;Fabre et al, 1983;Fays et al, 2003;Glod et al, 2003;Knowles et al, 2003;Lineberry et al, 2001;Loo et al, 2003;Malesker et al, 1995;McCollom et al, 2000;Peloso and Baillie, 1999;Tripathi and Greenberger, 1999;Wooltorton, 2002;Yolles et al, 1999).…”

Section: Norepinephrine Dopamine Reuptake Inhibitorsmentioning

confidence: 99%

Monoaminergic‐based Pharmacotherapy for Depression

Papakostas¹,

Fava²

2005

Biology of Depression

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Although recent advances in neuropharmacology, neuroendocrinology, molecular biology, and pharmacogenetics have been instrumental in bringing about potential treatments for depression which are fundamentally unrelated to their predecessors, including substance P antagonists, glutaminergic agents, and corticotropinreleasing factor (CRF) antagonists, nevertheless it was agents that influenced the function of monoamine receptors and transporters that were discovered initially by serendipity and then developed as treatments for depression. The development of such compounds also served as a framework for the understanding of depression as a medical illness affecting brain functioning. As a result of these efforts, our field has gained further understanding of the role of monoamines in depression. In previous chapters, the relevance of monoamines in the underlying pathophysiology of depression was reviewed. In the following chapter we will focus on describing the contemporary role of monoaminergic agents in the treatment of depression. 6.

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Bupropion-Induced Serum Sickness–Like Reaction

Abstract: SSLRs following bupropion ingestion appear to be rare. However, the fact that this cluster of patients presented to our emergency department within a three-week period suggests that this reaction may be underreported.

Cited by 55 publications

References 5 publications

Serum Sickness-Like reaction developed due to Bupropion Hcl during smoking cessation therapy: Case Report

Serum Sickness-Like reaction developed due to Bupropion Hcl during smoking cessation therapy: Case Report

Bupropion Hydrochloride Induced Serum Sickness-Like Reaction

Monoaminergic‐based Pharmacotherapy for Depression

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