Bupropion-Induced Delayed-Onset Anaphylaxis

Risma, Cameron J.; Pazderka, Matthew J.; Chong, Yon J.; Sharma, Ashish

doi:10.4088/pcc.14l01770

Cited by 3 publications

(2 citation statements)

References 5 publications

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“…Common adverse reactions to the drug may range from being mild (such as agitation, dry mouth, headache, insomnia, and nausea) to severe (such as hypersensitivity reactions, seizures, and suicidality) [3]. Rarely, bupropion may elicit other serious reactions such as anaphylaxis, angioedema, erythema multiforme, generalized exanthematous pustulosis, serum sickness-like reaction, Steven-Johnson's syndrome, and urticaria [5][6][7][8][9][10][11][12].…”

Section: Discussionmentioning

confidence: 99%

Bupropion-Associated Delayed Onset Urticaria

Gutierrez

Malik²,

Cohen³

et al. 2021

Cureus

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Bupropion is an oral antidepressant that is commonly used to treat various mood disorders. Its therapeutic mechanism of action results from inhibiting the reuptake of norepinephrine and dopamine. Bupropion is generally well-tolerated and patients usually experience no side effects or mild adverse events. Rarely, hypersensitivity reactions to bupropion, such as urticaria, have been observed. However, the prevalence of delayed onset bupropion-associated urticaria may not be properly reflected in the literature due to misdiagnosis of the condition caused by its atypical presentation. We report a 20-year-old man with delayed onset bupropion-associated urticaria; he had been on bupropion for three weeks and subsequently developed new severely pruritic, erythematous wheals on his abdomen, bilateral flanks, and upper extremities. The clinical features of this rare adverse reaction to bupropion are also summarized.

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Section: Discussionmentioning

confidence: 99%

Bupropion-Associated Delayed Onset Urticaria

Gutierrez

Malik²,

Cohen³

et al. 2021

Cureus

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“…In those cases, the onset of the allergic reactions began 12 hours to a few days after treatment. [3][4][5][6][7][8][9][10][11][12] In this report, we describe a patient who developed anaphylaxis to intravenous colistin after about a month of daily administration, during which he had no signs or symptoms suggestive of any form of allergies to the medication. In addition, we describe the outcomes following the re-administration of colistin after the initial episode of anaphylaxis.…”

Section: Introductionmentioning

confidence: 98%

Delayed Anaphylaxis to Intravenous Colistin in a Critically Ill Cancer Patient: A Case Report

Awad

Alsheyyab

Nazer

et al. 2023

Clin Med Insights Case Rep

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Introduction: Anaphylaxis is an acute, life-threatening, multi-system syndrome that has been reported with a wide range of medications. Though anaphylaxis usually has a rapid onset, we describe a patient who developed anaphylaxis to intravenous colistin after 28 days of daily administration. Case presentation: A 20 years-old Caucasian male patient, with a history of relapsed acute myeloid leukemia, was transferred from the medical floor to our intensive care unit with septic shock. The source of infection was presumed to be a recto-cecal abscess and arm cellulitis. Cultures were positive for extended spectrum beta-lactamase (ESBL) and carbapenem-resistant enterobacteriaceae (CRE) Escherichia coli. for which he was receiving broad spectrum antibiotics, as well as intravenous colistin, started about 4 weeks earlier. On day 2 of ICU admission, and during the administration of colistin, the patient experienced an anaphylactic reaction. He developed hypotension requiring the initiation of norepinephrine, shortness of breath, hypoxia, tachycardia, and tachypnea. The reaction was resolved after supportive therapy but it was thought to be related to septic shock and therefore the patient continued on colistin the following day. The patient tolerated colistin for the next 3 days before developing another similar, but more severe, reaction. Colistin was discontinued and the symptoms resolved following supportive therapy. Conclusion: This case highlights the importance of being aware of delayed serious reactions that may occur several weeks after initiation of drug therapy. In addition, successful re-initiation may not necessarily rule out the recurrence of such reactions and therefore close monitoring is crucial.

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Bupropion

2015

Reactions Weekly

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Bupropion-Induced Delayed-Onset Anaphylaxis

Cited by 3 publications

References 5 publications

Bupropion-Associated Delayed Onset Urticaria

Bupropion-Associated Delayed Onset Urticaria

Delayed Anaphylaxis to Intravenous Colistin in a Critically Ill Cancer Patient: A Case Report

Bupropion

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